4X2F
Selection of fragments for kinase inhibitor design: decoration is key
Summary for 4X2F
Entry DOI | 10.2210/pdb4x2f/pdb |
Related | 4X2G |
Descriptor | TGF-beta receptor type-1, 4-amino-8-(4-aminophenyl)pyrido[2,3-d]pyrimidin-5(8H)-one, SULFATE ION, ... (4 entities in total) |
Functional Keywords | transferase, protein kinase, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P36897 |
Total number of polymer chains | 1 |
Total formula weight | 35231.47 |
Authors | Czodrowski, P.,Hoelzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. (deposition date: 2014-11-26, release date: 2015-10-28, Last modification date: 2024-02-28) |
Primary citation | Czodrowski, P.,Holzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. Selection of fragments for kinase inhibitor design: decoration is key. J.Med.Chem., 58:457-465, 2015 Cited by PubMed: 25437144DOI: 10.1021/jm501597j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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