4X2F
Selection of fragments for kinase inhibitor design: decoration is key
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | TGF-beta receptor type-1 | polymer | 305 | 34882.1 | 1 | UniProt (P36897) Pfam (PF00069) In PDB | Homo sapiens (Human) | TGFR-1,Activin A receptor type II-like protein kinase of 53kD,Activin receptor-like kinase 5,ALK5,Serine/threonine-protein kinase receptor R4,SKR4,TGF-beta type I receptor,Transforming growth factor-beta receptor type I,TbetaR-I |
| 2 | A | 4-amino-8-(4-aminophenyl)pyrido[2,3-d]pyrimidin-5(8H)-one | non-polymer | 253.3 | 1 | Chemie (3WJ) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 263 | Chemie (HOH) |
Sequence modifications
A: 200 - 503 (UniProt: P36897)
| PDB | External Database | Details |
|---|---|---|
| Gly 199 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34882.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 349.3 | |
| All* | Total formula weight | 35231.5 |
