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8C1E

Aurora A kinase in complex with TPX2-inhibitor 9

Summary for 8C1E
Entry DOI10.2210/pdb8c1e/pdb
DescriptorAurora kinase A, 4-(4-chloranyl-3-cyano-phenyl)-7-methyl-1~{H}-indole-6-carboxylic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsprotein-ligand complex, kinase, protein-protein interaction inhibitor, cell cycle
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight32378.35
Authors
Primary citationStockwell, S.,Scott, D.,Fischer, G.,Guarino Almeida, E.,Rooney, T.,Feng, J.,Moschetti, T.,Dagostin, C.,Alcaide-Lopez, A.,Rocaboy, M.,Srinivasan, R.,Asteian, A.,Alza, E.,Blaszczyk, B.,Wang, X.,Rossmann, M.,Perrior, T.,Blundell, T.L.,Spring, D.R.,McKenzie, G.,Abell, C.,Skidmore, J.,Venkitaraman, A.,Hyvonen, M.
Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agent
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.798 Å)
Structure validation

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