8C1E
Aurora A kinase in complex with TPX2-inhibitor 9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aurora kinase A | polymer | 272 | 31536.1 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | A | 4-(4-chloranyl-3-cyano-phenyl)-7-methyl-1~{H}-indole-6-carboxylic acid | non-polymer | 310.7 | 1 | Chemie (T0X) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 5 | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A: 125 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 120 | - | expression tag |
| Ser 121 | - | expression tag |
| Met 122 | - | expression tag |
| Gly 123 | - | expression tag |
| Ser 124 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31536.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 842.2 | |
| All* | Total formula weight | 32378.4 |
