4PBD
 
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8GY7
 | | Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein | | 分子名称: | CALCIUM ION, Corticotropin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Luo, P, Feng, W.B, Ma, S.S, Dai, A.T, Yuan, Q.N, Wu, K, Yang, D.H, Wang, M.W, Xu, H.E, Jiang, Y. | | 登録日 | 2022-09-21 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1.
Cell Res., 33, 2023
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4X7Q
 | | PIM2 kinase in complex with Compound 1s | | 分子名称: | 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide, PHOSPHATE ION, Serine/threonine-protein kinase pim-2 | | 著者 | Marcotte, D.J, Silvian, L.F. | | 登録日 | 2014-12-09 | | 公開日 | 2015-02-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Structure-based design of low-nanomolar PIM kinase inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
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8QRP
 | | ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the outward-facing state (OFS.1) | | 分子名称: | GLUTAMINE, Neutral amino acid transporter B(0), SODIUM ION | | 著者 | Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J. | | 登録日 | 2023-10-09 | | 公開日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
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8BLS
 | | Structure of Lactobacillus salivarius (Ls) bile salt hydrolase(BSH) in complex with Glycocholate (GCA) | | 分子名称: | Bile salt hydrolase, GLYCOCHOLIC ACID | | 著者 | Karlov, D.S, Long, S.L, Zeng, X, Xu, F, Lal, K, Cao, L, Hayoun, K, Lin, J, Joyce, S.A, Tikhonova, I.G. | | 登録日 | 2022-11-10 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Characterization of the mechanism of bile salt hydrolase substrate specificity by experimental and computational analyses.
Structure, 31, 2023
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2A1J
 | | Crystal Structure of the Complex between the C-Terminal Domains of Human XPF and ERCC1 | | 分子名称: | DNA excision repair protein ERCC-1, DNA repair endonuclease XPF, MERCURY (II) ION | | 著者 | Tsodikov, O.V, Enzlin, J.H, Scharer, O.D, Ellenberger, T. | | 登録日 | 2005-06-20 | | 公開日 | 2005-08-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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6NV7
 | | BACE1 in complex with a macrocyclic inhibitor | | 分子名称: | (E)-N-(2-methylpropylidene)-N~2~-{[(4S)-17-[(methylsulfonyl)(propyl)amino]-2-oxo-3-azatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaen-4-yl]methyl}-D-threoninamide, Beta-secretase 1 | | 著者 | Yen, Y.C, Ghosh, A.K, Mesecar, A.D. | | 登録日 | 2019-02-04 | | 公開日 | 2019-10-09 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.132 Å) | | 主引用文献 | Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors.
Biochemistry, 58, 2019
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4WOY
 | | Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial fission protein Drp1 | | 分子名称: | Mitochondrial dynamics protein MID49 | | 著者 | Loson, O.C, Meng, S, Ngo, H.B, Liu, R, Kaiser, J.T, Chan, D.C. | | 登録日 | 2014-10-17 | | 公開日 | 2015-01-28 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial fission protein Drp1.
Protein Sci., 24, 2015
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7ALN
 | | Cryo-EM structure of the divergent actomyosin complex from Plasmodium falciparum Myosin A in the Rigor state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin-1, Jasplakinolide, ... | | 著者 | Robert-Paganin, J, Xu, X.-P, Swift, M.F, Auguin, D, Robblee, J.P, Lu, H, Fagnant, P.M, Krementsova, E.B, Trybus, K.M, Houdusse, A, Volkmann, N, Hanein, D. | | 登録日 | 2020-10-06 | | 公開日 | 2021-04-28 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | | 主引用文献 | The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity.
Nat Commun, 12, 2021
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4WPA
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2A36
 | | Solution structure of the N-terminal SH3 domain of DRK | | 分子名称: | Protein E(sev)2B | | 著者 | Forman-Kay, J.D, Bezsonova, I, Singer, A, Choy, W.-Y, Tollinger, M. | | 登録日 | 2005-06-23 | | 公開日 | 2005-12-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Comparison of the Unstable drkN SH3 Domain and a Stable Mutant
Biochemistry, 44, 2005
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8QRO
 | | ASCT2 trimer in lipid nanodiscs with bound glutamine and Na+ ions in the outward-facing state (OFS) | | 分子名称: | GLUTAMINE, Neutral amino acid transporter B(0), SODIUM ION | | 著者 | Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J. | | 登録日 | 2023-10-09 | | 公開日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
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6MUR
 | | Cryo-EM structure of Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system | | 分子名称: | RNA (27-MER), RNA (5'-R(P*GP*CP*AP*AP*AP*CP*CP*GP*CP*CP*UP*CP*UP*GP*CP*CP*CP*GP*C)-3'), Uncharacterized protein, ... | | 著者 | Jia, N, Wang, C, Eng, E.T, Patel, D.J. | | 登録日 | 2018-10-23 | | 公開日 | 2018-12-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
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8BLT
 | | Structure of Lactobacillus salivarius (Ls) bile salt hydrolase(BSH) in complex with taurocholate (TCA) | | 分子名称: | Bile salt hydrolase, TAUROCHOLIC ACID | | 著者 | Karlov, D.S, Long, S.L, Zeng, X, Xu, F, Lal, K, Cao, L, Hayoun, K, Lin, J, Joyce, S.A, Tikhonova, I.G. | | 登録日 | 2022-11-10 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Characterization of the mechanism of bile salt hydrolase substrate specificity by experimental and computational analyses.
Structure, 31, 2023
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4ADV
 | | Structure of the E. coli methyltransferase KsgA bound to the E. coli 30S ribosomal subunit | | 分子名称: | 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ... | | 著者 | Boehringer, D, O'Farrell, H.C, Rife, J.P, Ban, N. | | 登録日 | 2012-01-03 | | 公開日 | 2012-02-15 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (13.5 Å) | | 主引用文献 | Structural Insights Into Methyltransferase Ksga Function in 30S Ribosomal Subunit Biogenesis
J.Biol.Chem., 287, 2012
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6MUT
 | | Cryo-EM structure of ternary Csm-crRNA-target RNA with anti-tag sequence complex in type III-A CRISPR-Cas system | | 分子名称: | RNA (5'-R(*GP*UP*GP*GP*AP*AP*AP*GP*GP*CP*GP*GP*GP*CP*AP*GP*AP*GP*GP*C)-3'), RNA (5'-R(P*CP*CP*UP*CP*UP*GP*CP*CP*CP*GP*CP*CP*UP*UP*UP*CP*CP*AP*C)-3'), Uncharacterized protein Csm1, ... | | 著者 | Jia, N, Wang, C, Eng, E.T, Patel, D.J. | | 登録日 | 2018-10-23 | | 公開日 | 2018-12-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
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4PKX
 | | The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold | | 分子名称: | Protein C10C5.1, isoform i | | 著者 | Kamajaya, A, Kaiser, J, Lee, J, Reid, M, Rees, D.C. | | 登録日 | 2014-05-15 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct beta Sandwich Fold.
Structure, 22, 2014
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6GJU
 | | human NBD1 of CFTR in complex with nanobodies T2a and T4 | | 分子名称: | Cystic fibrosis transmembrane conductance regulator, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. | | 登録日 | 2018-05-17 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10, 2019
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6YAP
 | | Crystal structure of ZmCKO4a in complex with inhibitor 1-(3-Chloro-5-trifluoromethoxy-phenyl)-3-[2-(2-hydroxy-ethyl)-phenyl]-urea | | 分子名称: | 1,2-ETHANEDIOL, 1-(3-Chloro-5-trifluoromethoxy-phenyl)-3-[2-(2-hydroxy-ethyl)-phenyl]-urea, Cytokinin dehydrogenase 4, ... | | 著者 | Kopecny, D, Briozzo, P, Morera, S. | | 登録日 | 2020-03-12 | | 公開日 | 2020-10-14 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Diphenylurea-derived cytokinin oxidase/dehydrogenase inhibitors for biotechnology and agriculture.
J.Exp.Bot., 72, 2021
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4WYZ
 | | The crystal structure of the A109G mutant of RNase A in complex with 3'UMP | | 分子名称: | 3'-URIDINEMONOPHOSPHATE, Ribonuclease pancreatic | | 著者 | French, R.L, Gagne, D, Doucet, N, Simonovic, M. | | 登録日 | 2014-11-18 | | 公開日 | 2015-11-18 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.449 Å) | | 主引用文献 | Perturbation of the Conformational Dynamics of an Active-Site Loop Alters Enzyme Activity.
Structure, 23, 2015
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1DY3
 | | Ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue. | | 分子名称: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 7,8-DIHYDRO-6-HYDROXYMETHYL-7-METHYL-7-[2-PHENYLETHYL]-PTERIN, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Stammers, D.K, Achari, A, Somers, D.O, Bryant, P.K, Rosemond, J, Scott, D.L, Champness, J.N. | | 登録日 | 2000-01-21 | | 公開日 | 2000-08-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | 2.0A X-Ray Structure of the Ternary Complex of 7,8-Dihydro-6-Hydroxymethylpterinpyrophosphokinase from Escherichia Coli with ATP and a Substrate Analogue
FEBS Lett., 456, 1999
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2W2R
 | | Structure of the vesicular stomatitis virus matrix protein | | 分子名称: | MATRIX PROTEIN | | 著者 | Graham, S.C, Assenberg, R, Delmas, O, Verma, A, Gholami, A, Talbi, C, Owens, R.J, Stuart, D.I, Grimes, J.M, Bourhy, H. | | 登録日 | 2008-11-03 | | 公開日 | 2009-01-13 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Rhabdovirus Matrix Protein Structures Reveal a Novel Mode of Self-Association.
Plos Pathog., 4, 2008
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9BGR
 | | X-ray structure of the aminotransferase from Vibrio vulnificus responsible for the biosynthesis of 2,3-diacetamido-4-amino-2,3,4-trideoxy-arabinose in the presence of its external aldimine with 2,3-diacetamido-4-amino-2,3,4-trideoxy-l-arabinose | | 分子名称: | (2R,3R,4R,5R)-3,4-diacetamido-5-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methoxy)oxan-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name), 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | 著者 | Fait, D.J, Thoden, J.B, Holden, H.M. | | 登録日 | 2024-04-19 | | 公開日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Biochemical Investigation of an Aminotransferase Required for the Production of 2,3,4-triacetamido-2,3,4-trideoxy-L-arabinose
To Be Published
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1M0G
 | | Solution structure of the alpha domain of mt_nc | | 分子名称: | CADMIUM ION, metallothionein MT_nc | | 著者 | Capasso, C, Carginale, V, Crescenzi, O, Di Maro, D, Parisi, E, Spadaccini, R, Temussi, P.A. | | 登録日 | 2002-06-13 | | 公開日 | 2003-05-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of MT_nc, a Novel Metallothionein from the Antarctic Fish Notothenia coriiceps.
Structure, 11, 2003
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4P8Z
 | | Speciation of a group I intron into a lariat capping ribozyme | | 分子名称: | Didymium iridis partial IGS, 18S rRNA gene, I-DirI gene and partial ITS1 | | 著者 | Meyer, M, Nielsen, H, Olieric, V, Roblin, P, Johansen, S.D, Westhof, E, Masquida, B. | | 登録日 | 2014-04-01 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.85 Å) | | 主引用文献 | Speciation of a group I intron into a lariat capping ribozyme.
Proc.Natl.Acad.Sci.USA, 111, 2014
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