7QOU
| A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability | 分子名称: | CHLORIDE ION, COBALT (II) ION, MAGNESIUM ION, ... | 著者 | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | 登録日 | 2021-12-29 | 公開日 | 2023-01-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Engineering enhanced thermostability into the Geobacillus pallidus nitrile hydratase. Curr Res Struct Biol, 4, 2022
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7QOV
| The wild type nitrile hydratase from Geobacillus pallidus | 分子名称: | CHLORIDE ION, COBALT (III) ION, Nitrile hydratase, ... | 著者 | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | 登録日 | 2021-12-29 | 公開日 | 2023-01-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Engineering enhanced thermostability into the Geobacillus pallidus nitrile hydratase. Curr Res Struct Biol, 4, 2022
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6N8C
| Structure of the Huntingtin tetramer/dimer mixture determined by paramagnetic NMR | 分子名称: | Huntingtin | 著者 | Schwieters, C.D, Kotler, S.A, Schmidt, T, Ceccon, A, Ghirlando, R, Libich, D.S, Clore, G.M. | 登録日 | 2018-11-29 | 公開日 | 2019-02-13 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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8D9A
| Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with fluorinated inhibitor 8 | 分子名称: | 2,3,5-trifluoro-N-hydroxybenzamide, Hdac6 protein, POTASSIUM ION, ... | 著者 | Watson, P.R, Christianson, D.W. | 登録日 | 2022-06-09 | 公開日 | 2022-09-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6. Biochemistry, 61, 2022
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5FMV
| Crystal structure of human CD45 extracellular region, domains d1-d4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C, SULFATE ION | 著者 | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | 登録日 | 2015-11-09 | 公開日 | 2016-03-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'. Nat.Immunol., 17, 2016
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7QOY
| A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability | 分子名称: | CHLORIDE ION, COBALT (III) ION, Nitrile hydratase, ... | 著者 | Van Wyk, J.C, Cowan, D.A, Danson, M.J, Tsekoa, T.L, Sayed, M.F, Sewell, B.T. | 登録日 | 2021-12-29 | 公開日 | 2023-01-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | A mutant of the nitrile hydratase from Geobacillus pallidus having enhanced thermostability To be published
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4WXS
| Crystal Structure of the E396D SNP Variant of the Myocilin Olfactomedin Domain | 分子名称: | CALCIUM ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | 著者 | Donegan, R.K, Freeman, D.M, Lieberman, R.L. | 登録日 | 2014-11-14 | 公開日 | 2015-04-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for misfolding in myocilin-associated glaucoma. Hum.Mol.Genet., 24, 2015
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8U3L
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5FN6
| Crystal structure of human CD45 extracellular region, domains d1-d3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C | 著者 | Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J. | 登録日 | 2015-11-10 | 公開日 | 2016-03-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'. Nat.Immunol., 17, 2016
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8D09
| Hallucinated C4 protein assembly HALC4_136 | 分子名称: | HALC4_136 | 著者 | Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D. | 登録日 | 2022-05-25 | 公開日 | 2022-09-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Hallucinating symmetric protein assemblies. Science, 378, 2022
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8D06
| Hallucinated C3 protein assembly HALC3_104 | 分子名称: | HALC3_104 | 著者 | Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D. | 登録日 | 2022-05-25 | 公開日 | 2022-09-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Hallucinating symmetric protein assemblies. Science, 378, 2022
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6VLM
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8D98
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8CTB
| Human PRMT5:MEP50 structure with Fragment 3 and MTA Bound | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, 7-chloro-1-methyl-1H-benzimidazol-2-amine, Methylosome protein 50, ... | 著者 | Gunn, R.J, Lawson, J.D, Smith, C.R. | 登録日 | 2022-05-13 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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8Q9I
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8U3J
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8QCR
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7LKH
| Chicken Scap D435V L1-L7 domain / Fab complex focused map | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4G10 Fab heavy chain, 4G10 Fab kappa chain, ... | 著者 | Kober, D.L, Radhakrishnan, A, Goldstein, J.L, Brown, M.S, Clark, L.D, Bai, X.-C, Rosenbaum, D.M. | 登録日 | 2021-02-02 | 公開日 | 2021-06-30 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing. Cell, 184, 2021
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4WX4
| Crystal structure of adenovirus 8 protease in complex with a nitrile inhibitor | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCINE, N-[(2-cyanopyrimidin-4-yl)methyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide, ... | 著者 | Grosche, P, Sirockin, F, Mac Sweeney, A, Ramage, P, Erbel, P, Melkko, S, Bernardi, A, Hughes, N, Ellis, D, Combrink, K, Jarousse, N, Altmann, E. | 登録日 | 2014-11-13 | 公開日 | 2015-01-14 | 最終更新日 | 2015-01-28 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Structure-based design and optimization of potent inhibitors of the adenoviral protease. Bioorg.Med.Chem.Lett., 25, 2015
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7LFM
| MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE, VAL MUTANT, TRICLINIC CELL, REFINED AT 1.60 ANGSTROMS RESOLUTION | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Heptapeptide from NADH-ubiquinone oxidoreductase chain 1, ... | 著者 | Tomchick, D.R, Deisenhofer, J, Shen, S. | 登録日 | 2021-01-17 | 公開日 | 2021-07-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides. J.Biomol.Struct.Dyn., 40, 2022
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7TT7
| BamABCDE bound to substrate EspP in the barrelized EspP/continuous open BamA state | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Serine protease EspP chimera, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamC, ... | 著者 | Doyle, M.T, Jimah, J.R, Dowdy, T, Ohlemacher, S.I, Larion, M, Hinshaw, J.E, Bernstein, H.D. | 登録日 | 2022-01-31 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. Cell, 185, 2022
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7LFK
| MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE, THR MUTANT, REFINED AT 1.60 ANGSTROMS RESOLUTION | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Heptapeptide from NADH-ubiquinone oxidoreductase chain 1, ... | 著者 | Tomchick, D.R, Deisenhofer, J, Shen, S. | 登録日 | 2021-01-17 | 公開日 | 2021-07-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides. J.Biomol.Struct.Dyn., 40, 2022
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7TT6
| BamABCDE bound to substrate EspP in the intermediate-open EspP state | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Serine protease EspP chimera, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamC, ... | 著者 | Doyle, M.T, Jimah, J.R, Dowdy, T, Ohlemacher, S.I, Larion, M, Hinshaw, J.E, Bernstein, H.D. | 登録日 | 2022-01-31 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. Cell, 185, 2022
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6FS1
| MCL1 in complex with an indole acid ligand | 分子名称: | 1,2-ETHANEDIOL, 7-[3-[(1,5-dimethylpyrazol-3-yl)methylsulfanylmethyl]-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Kasmirski, S, Hargreaves, D. | 登録日 | 2018-02-18 | 公開日 | 2018-12-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun, 9, 2018
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4WZP
| Ser65 phosphorylated ubiquitin, major conformation | 分子名称: | SULFATE ION, ubiquitin | 著者 | Wauer, T, Wagstaff, J, Freund, S.M.V, Komander, D. | 登録日 | 2014-11-20 | 公開日 | 2015-01-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. Embo J., 34, 2015
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