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PDB: 53012 件

8T0J
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Salmonella Typhimurium ArnD
分子名称: Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
著者Sousa, M.C, Munoz-Escudero, D, Lee, M.
登録日2023-06-01
公開日2023-10-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Structure and Function of ArnD. A Deformylase Essential for Lipid A Modification with 4-Amino-4-deoxy-l-arabinose and Polymyxin Resistance.
Biochemistry, 62, 2023
6ZSM
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BU of 6zsm by Molmil
Crystal structure of rsGCaMP double mutant Ile80His/Val116Ile in the ON state (non-illuminated)
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, FORMIC ACID, ...
著者Janowski, R, Fuenzalida-Werner, J.P, Mishra, K, Stiel, A.C, Niessing, D.
登録日2020-07-16
公開日2021-10-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging.
Nat.Biotechnol., 40, 2022
6XBD
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Cryo-EM structure of MlaFEDB in nanodiscs with phospholipid substrates
分子名称: DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, MSP1D1, Phospholipid ABC transporter permease protein MlaE, ...
著者Coudray, N, Isom, G.L, MacRae, M.R, Saiduddin, M, Ekiert, D.C, Bhabha, G.
登録日2020-06-05
公開日2020-07-01
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Structure of bacterial phospholipid transporter MlaFEDB with substrate bound.
Elife, 9, 2020
5LTL
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BU of 5ltl by Molmil
Structure of human chemokine CCL16
分子名称: C-C motif chemokine 16, GLYCEROL, SODIUM ION
著者Weiergraeber, O.H, Batra-Safferling, R, Haenel, K, Willbold, D.
登録日2016-09-07
公開日2018-05-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structure and dynamics of human chemokine CCL16
To Be Published
7RZB
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BU of 7rzb by Molmil
BrxA from Staphylococcus aureus with bacillithiol mixed disulfide
分子名称: (2S)-2-{[2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranosyl]oxy}butanedioic acid, Bacillithiol system oxidoreductase, YphP/YqiW family, ...
著者Cook, P.D, McHugh, C.S.
登録日2021-08-27
公開日2022-04-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of BrxA from Staphylococcus aureus, a bacilliredoxin involved in redox homeostasis in Firmicutes.
Acta Crystallogr.,Sect.F, 78, 2022
7ADX
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SFX structure of dehaloperoxidase B in the oxyferrous form
分子名称: Dehaloperoxidase B, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Moreno Chicano, T, Ebrahim, A, Worrall, J.W, Axford, D.A, Owada, S, Tosha, T, Sugimoto, H, Strange, R.W, Owen, R.L, Hough, M.A.
登録日2020-09-16
公開日2021-10-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献SFX structure of dehaloperoxidase B from Amphitrite ornata in the oxyferrous form
To Be Published
5LUM
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BU of 5lum by Molmil
Alpha-crystallin domain of human HSPB6 patched with its N-terminal peptide
分子名称: Heat shock protein beta-6, SULFATE ION
著者Sluchanko, N.N, Beelen, S, Kulikova, A.A, Weeks, S.D, Antson, A.A, Gusev, N.B, Strelkov, S.V.
登録日2016-09-09
公開日2017-02-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.
Structure, 25, 2017
8G98
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Adenylation domain structure from NRPS-like Delta-Poly-L-Ornithine synthetase (L-Lysine bound)
分子名称: Dimodular nonribosomal peptide synthase, GLYCEROL, LYSINE
著者Patel, K.D, Gulick, A.M.
登録日2023-02-21
公開日2023-10-04
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structural and functional insights into delta-poly-L-ornithine polymer biosynthesis from Acinetobacter baumannii.
Commun Biol, 6, 2023
4X9Z
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BU of 4x9z by Molmil
Dimeric conotoxin alphaD-GeXXA
分子名称: alphaD-conotoxin GeXXA from the venom of Conus generalis
著者Xu, S, Zhang, T, Kompella, S, Adams, D, Ding, J, Wang, C.
登録日2014-12-12
公開日2015-12-02
最終更新日2020-02-05
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Conotoxin alpha D-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors
Sci Rep, 5, 2015
6X84
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Sn-glycerol-3-phosphate binding periplasmic protein UgpB from Escherichia coli - W169S, W172S
分子名称: GLYCEROL, sn-glycerol-3-phosphate-binding periplasmic protein UgpB
著者Wu, K, Zyla, D, Bardwell, J.C.A.
登録日2020-06-01
公開日2020-08-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献A metabolite binding protein moonlights as a bile-responsive chaperone.
Embo J., 39, 2020
5F0E
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BU of 5f0e by Molmil
Murine endoplasmic reticulum alpha-glucosidase II
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Caputo, A.T, Roversi, P, Alonzi, D.S, Kiappes, J.L, Zitzmann, N.
登録日2015-11-27
公開日2016-07-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IH8
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BU of 5ih8 by Molmil
MELK in complex with NVS-MELK1
分子名称: Maternal embryonic leucine zipper kinase, N-[(pyridin-2-yl)methyl]-4-[4-(pyridin-4-yl)-1H-pyrazol-1-yl]benzamide
著者Sprague, E.R, Puleo, D.E.
登録日2016-02-29
公開日2016-06-01
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.
J.Med.Chem., 59, 2016
6ALD
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BU of 6ald by Molmil
RABBIT MUSCLE ALDOLASE A/FRUCTOSE-1,6-BISPHOSPHATE COMPLEX
分子名称: 1,6-FRUCTOSE DIPHOSPHATE (LINEAR FORM), FRUCTOSE-1,6-BIS(PHOSPHATE) ALDOLASE
著者Choi, K.H, Mazurkie, A.S, Morris, A.J, Utheza, D, Tolan, D.R, Allen, K.N.
登録日1998-12-23
公開日2000-01-05
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of a fructose-1,6-bis(phosphate) aldolase liganded to its natural substrate in a cleavage-defective mutant at 2.3 A(,).
Biochemistry, 38, 1999
5LEV
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BU of 5lev by Molmil
Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant)
分子名称: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, UNKNOWN LIGAND
著者Pike, A.C.W, Dong, Y.Y, Chu, A, Tessitore, A, Goubin, S, Dong, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Berridge, G, Wang, D, Kupinska, K, Belaya, K, Beeson, D, Burgess-Brown, N, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
登録日2016-06-30
公開日2016-12-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.
Cell, 175, 2018
6MG5
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BU of 6mg5 by Molmil
Structure of full-length human lambda-6A light chain JTO in complex with coumarin 1
分子名称: 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one, Light chain JTO, PHOSPHATE ION
著者Morgan, G.J, Yan, N.L, Mortenson, D.E, Stanfield, R.L, Wilson, I.A, Kelly, J.W.
登録日2018-09-12
公開日2019-04-10
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Proc.Natl.Acad.Sci.USA, 116, 2019
7PER
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BU of 7per by Molmil
Model of the inner ring of the human nuclear pore complex
分子名称: Nuclear pore complex protein Nup155, Nuclear pore complex protein Nup205, Nuclear pore complex protein Nup93, ...
著者Schuller, A.P, Wojtynek, M, Mankus, D, Tatli, M, Kronenberg-Tenga, R, Regmi, S.G, Dasso, M, Weis, K, Medalia, O, Schwartz, T.U.
登録日2021-08-11
公開日2021-10-20
最終更新日2021-11-24
実験手法ELECTRON MICROSCOPY (35 Å)
主引用文献The cellular environment shapes the nuclear pore complex architecture.
Nature, 598, 2021
7NPX
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BU of 7npx by Molmil
Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 3-(3-Methoxyquinoxalin-2-yl)propanoic acid at 24 hours of soaking
分子名称: 3-(3-methoxyquinoxalin-2-yl)propanoic acid, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Fata, F, Silvestri, I, Williams, D.L, Angelucci, F.
登録日2021-02-28
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments.
Acs Infect Dis., 7, 2021
7PKX
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BU of 7pkx by Molmil
Crystal structure of a DyP-type peroxidase from Bacillus subtilis in P3121 space group
分子名称: Deferrochelatase/peroxidase, PROTOPORPHYRIN IX CONTAINING FE
著者Borges, P.T, Rodrigues, C, Silva, D, Taborda, A, Brissos, V, Frazao, C, Martins, L.O.
登録日2021-08-27
公開日2021-10-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.491 Å)
主引用文献Loops around the Heme Pocket Have a Critical Role in the Function and Stability of Bs DyP from Bacillus subtilis .
Int J Mol Sci, 22, 2021
6ANV
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BU of 6anv by Molmil
Crystal structure of anti-CRISPR protein AcrF1
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ...
著者Yang, H, Patel, D.J.
登録日2017-08-14
公開日2017-10-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.265 Å)
主引用文献Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex.
Cell, 171, 2017
5BP4
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Modifying region (DH-ER-KR) of a mycocerosic acid synthase-like (MAS-like) PKS
分子名称: Mycocerosic acid synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Herbst, D.A, Jakob, P.R, Zaehringer, F, Maier, T.
登録日2015-05-27
公開日2016-03-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.75 Å)
主引用文献Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases.
Nature, 531, 2016
6R90
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Cryo-EM structure of NCP-THF2(+1)-UV-DDB class A
分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ...
著者Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H.
登録日2019-04-02
公開日2019-06-12
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献DNA damage detection in nucleosomes involves DNA register shifting.
Nature, 571, 2019
6AR9
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BU of 6ar9 by Molmil
Crystal structure of hypoxanthine-guanine-xanthine phosphorybosyltranferase in complex with [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid
分子名称: Hypoxanthine-guanine phosphoribosyltransferase, putative, MAGNESIUM ION, ...
著者Teran, D, Gudday, L.W.
登録日2017-08-21
公開日2018-03-14
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.
PLoS Negl Trop Dis, 12, 2018
4XFR
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BU of 4xfr by Molmil
Crystal structure of a domain of unknown function (DUF1537) from Bordetella bronchiseptica (BB3215), Target EFI-511620, with bound citrate, domain swapped dimer, space group P6522
分子名称: CITRIC ACID, Uncharacterized protein
著者Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
登録日2014-12-28
公開日2015-01-28
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars.
Proc.Natl.Acad.Sci.USA, 113, 2016
6E6E
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BU of 6e6e by Molmil
DGY-06-116, a novel and selective covalent inhibitor of SRC kinase
分子名称: N-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide, Proto-oncogene tyrosine-protein kinase Src
著者Gurbani, D, Bera, A, Westover, K.
登録日2018-07-24
公開日2019-07-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure and Characterization of a Covalent Inhibitor of Src Kinase.
Front Mol Biosci, 7, 2020
7PGL
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HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), apo-form
分子名称: Hedgehog-interacting protein
著者Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C.
登録日2021-08-14
公開日2021-12-15
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Nat Commun, 12, 2021

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