8UW8
 
 | | Site-one protease and SPRING | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Membrane-bound transcription factor site-1 protease, ... | | 著者 | Kober, D.L. | | 登録日 | 2023-11-06 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain.
Nat Commun, 15, 2024
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7OVK
 | | Protein kinase MKK7 in complex with 5-bromo-2-hydroxyphenyl-substituted pyrazolopyrimidine | | 分子名称: | 1-[(3~{R})-3-[4-azanyl-3-[1-(5-bromanyl-2-oxidanyl-phenyl)-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one, Dual specificity mitogen-activated protein kinase kinase 7, GLYCEROL | | 著者 | Kleinboelting, S, Buehrmann, M, Mueller, M.P, Rauh, D. | | 登録日 | 2021-06-15 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.
J.Med.Chem., 65, 2022
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7P2X
 | | E.coli GyrB24 with inhibitor KOB20 (EBL2583) | | 分子名称: | (2Z)-2-[[4,5-bis(bromanyl)-1H-pyrrol-2-yl]carbonylimino]-3-(phenylmethyl)-1,3-benzothiazole-6-carboxylic acid, DNA gyrase subunit B, PHOSPHATE ION | | 著者 | Stevenson, C.E.M, Lawson, D.M, Maxwell, A.M, Henderson, S.R, Kikelj, D, Benek, O, Zega, A, Zidar, N, Ilas, J, Tomasic, T, Masic, L.P. | | 登録日 | 2021-07-06 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | E.coli GyrB24 with inhibitor KOB20 (EBL2583)
TO BE PUBLISHED
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7MLZ
 | | Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain | | 分子名称: | B1-182.1 Fab heavy chain, B1-182.1 Fab light chain, Spike protein S1, ... | | 著者 | Zhou, T, Tsybovsky, T, Kwong, P.D. | | 登録日 | 2021-04-29 | | 公開日 | 2021-07-28 | | 最終更新日 | 2021-08-25 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.
Science, 373, 2021
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6ZRH
 | | Crystal structure of OXA-10loop24 in complex with ertapenem | | 分子名称: | (2S,3R,4S)-4-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase | | 著者 | Tassone, G, Di Pisa, F, Benvenuti, M, De Luca, F, Pozzi, C, Mangani, S, Docquier, J.D. | | 登録日 | 2020-07-13 | | 公開日 | 2021-07-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Mechanistic insights into carbapenem hydrolysis by OXA-48 and the OXA10-derived hybrids OXA-10 loop24 and loop48
To Be Published
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6P6D
 | | HUMAN IGG1 FC FRAGMENT, C239 INSERTION MUTANT | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, IgG1 Fc fragment | | 著者 | Gallagher, D.T, Dimasi, N, McCullough, C. | | 登録日 | 2019-06-03 | | 公開日 | 2020-04-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions.
Pharmaceutics, 11, 2019
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6P72
 | | Crystal Structure of the Cedar henipavirus Attachment G Glycoprotein global domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Attachment glycoprotein, ... | | 著者 | Xu, K, Nikolov, D.B, Xu, Y. | | 登録日 | 2019-06-04 | | 公開日 | 2019-09-25 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.283 Å) | | 主引用文献 | Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus.
Proc.Natl.Acad.Sci.USA, 116, 2019
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7P5L
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7PHY
 | | Vaccinia virus E2 | | 分子名称: | GLYCEROL, Protein E2 | | 著者 | Gao, W.N.D, Gao, C, Graham, S.C. | | 登録日 | 2021-08-19 | | 公開日 | 2021-09-01 | | 最終更新日 | 2022-02-09 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The crystal structure of vaccinia virus protein E2 and perspectives on the prediction of novel viral protein folds.
J.Gen.Virol., 103, 2022
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6UZ0
 | | Cardiac sodium channel with flecainide | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jiang, D, Shi, H, Tonggu, L, Lenaeus, M.J, Zheng, N, Catterall, W.A. | | 登録日 | 2019-11-14 | | 公開日 | 2020-01-01 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Structure of the Cardiac Sodium Channel.
Cell, 180, 2020
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6V1C
 | | Crystal structure of human trefoil factor 3 in complex with its cognate ligand | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-beta-D-galactopyranose, Trefoil factor 3 | | 著者 | Jarva, M.A, Lingford, J.P, John, A, Scott, N.E, Goddard-Borger, E.D. | | 登録日 | 2019-11-20 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Trefoil factors share a lectin activity that defines their role in mucus.
Nat Commun, 11, 2020
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8DML
 | | Vibrio parahaemolyticus VtrA/VtrC complex bound to the bile salt chenodeoxycholate | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, CHENODEOXYCHOLIC ACID, ... | | 著者 | Tomchick, D.R, Orth, K, Zou, A.J. | | 登録日 | 2022-07-08 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Molecular determinants for differential activation of the bile acid receptor from the pathogen Vibrio parahaemolyticus.
J.Biol.Chem., 299, 2023
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6PHM
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8DU2
 | | HnRNPA2 D290V LCD PM1 | | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | | 登録日 | 2022-07-26 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
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8VKN
 | | Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with mouse ACE2 (focused refinement of RBD and mouse ACE2) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | | 著者 | Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S. | | 登録日 | 2024-01-09 | | 公開日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | SARS-CoV-2 XBB.1.5 Spike Protein: Altered Receptor Binding, Antibody Evasion, and Retention of T Cell Recognition
To Be Published
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8DUW
 | | HnRNPA2 D290V LCD PM2 | | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | | 登録日 | 2022-07-27 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
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7Q21
 | | III2-IV2 respiratory supercomplex from Corynebacterium glutamicum | | 分子名称: | (1R)-2-(dodecanoyloxy)-1-[(phosphonooxy)methyl]ethyl tetradecanoate, (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ... | | 著者 | Kovalova, T, Moe, A, Krol, S, Yanofsky, D.J, Bott, M, Sjostrand, D, Rubinstein, J.L, Hogbom, M, Brzezinski, P. | | 登録日 | 2021-10-22 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | The respiratory supercomplex from C. glutamicum.
Structure, 30, 2022
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8BGG
 | | Cryo-EM structure of SARS-CoV-2 spike (Omicron BA.1 variant) in complex with nanobody W25 (map 5, focus refinement on RBD, W25 and adjacent NTD) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody W25, Spike glycoprotein, ... | | 著者 | Modhiran, N, Lauer, S, Spahn, C.M.T, Watterson, D, Schwefel, D. | | 登録日 | 2022-10-27 | | 公開日 | 2023-03-08 | | 実験手法 | ELECTRON MICROSCOPY (6.04 Å) | | 主引用文献 | Cryo-EM structure of SARS-CoV-2 spike (Omicron BA.1 variant) in complex with nanobody W25 (map 5, focus refinement on RBD, W25 and adjacent NTD)
To Be Published
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8E2N
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7PS9
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7ND4
 | | EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-88 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-88 Fab heavy chain, ... | | 著者 | Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D. | | 登録日 | 2021-01-30 | | 公開日 | 2021-03-03 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
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7PKN
 | | Structure of the human CCAN deltaCT complex | | 分子名称: | Centromere protein H, Centromere protein I, Centromere protein K, ... | | 著者 | Muir, K.W, Yatskevich, S, Bellini, D, Barford, D. | | 登録日 | 2021-08-25 | | 公開日 | 2022-04-27 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.
Science, 376, 2022
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6VTU
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7PMZ
 | | Crystal structure of Streptomyces coelicolor guaB (IMP dehydrogenase) bound to ATP and ppGpp at 2.0 A resolution | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5',3'-TETRAPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, ... | | 著者 | Fernandez-Justel, D, Revuelta, J.L, Buey, R.M. | | 登録日 | 2021-09-04 | | 公開日 | 2022-05-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase.
Protein Sci., 31, 2022
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7PII
 | | Structure of the human CCAN CENP-A alpha-satellite complex | | 分子名称: | Centromere protein C, DNA (122-MER), DNA (123-MER), ... | | 著者 | Yatskevich, S, Muir, K.W, Bellini, D, Barford, D. | | 登録日 | 2021-08-19 | | 公開日 | 2022-05-25 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.
Science, 376, 2022
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