7PS9
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Iberdomide (CC-220)
Summary for 7PS9
| Entry DOI | 10.2210/pdb7ps9/pdb |
| Descriptor | Cereblon isoform 4, ZINC ION, (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, ... (4 entities in total) |
| Functional Keywords | protein degradation, immunomodulatory imide drug, e3 ligase, signaling protein |
| Biological source | Magnetospirillum gryphiswaldense |
| Total number of polymer chains | 3 |
| Total formula weight | 42442.22 |
| Authors | Heim, C.,Hartmann, M.D. (deposition date: 2021-09-22, release date: 2022-03-16, Last modification date: 2024-01-31) |
| Primary citation | Heim, C.,Hartmann, M.D. High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system. Acta Crystallogr D Struct Biol, 78:290-298, 2022 Cited by PubMed: 35234143DOI: 10.1107/S2059798322000092 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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