8UW8
Site-one protease and SPRING
Summary for 8UW8
Entry DOI | 10.2210/pdb8uw8/pdb |
EMDB information | 42639 |
Descriptor | Membrane-bound transcription factor site-1 protease, SREBP regulating gene protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | serine protease cholesterol metabolism zymogen activation protein complex glycoprotein secretory pathway, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 139096.32 |
Authors | Kober, D.L. (deposition date: 2023-11-06, release date: 2024-07-10, Last modification date: 2024-07-24) |
Primary citation | Hendrix, S.,Dartigue, V.,Hall, H.,Bawaria, S.,Kingma, J.,Bajaj, B.,Zelcer, N.,Kober, D.L. SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain. Nat Commun, 15:5732-5732, 2024 Cited by PubMed: 38977690DOI: 10.1038/s41467-024-50068-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.3 Å) |
Structure validation
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