8UW8

Site-one protease and SPRING

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
B	2000640	biological_process	positive regulation of SREBP signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00137
Number of Residues	11
Details	SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGTfVAGvIAS

Chain	Residue	Details
A	HIS249-SER259

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site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSvAsPvVAG

Chain	Residue	Details
A	GLY412-GLY422

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	169
Details	TOPO_DOM: Lumenal => ECO:0000305|PubMed:32111832

Chain	Residue	Details
B	LYS36-ALA205

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32111832

Chain	Residue	Details
B	ASN67
A	HIS249
A	SER414

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:10644685

Chain	Residue	Details
A	LEU186

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
A	SER168

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site_id	SWS_FT_FI5
Number of Residues	5
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN236
A	ASN305
A	ASN515
A	ASN728
A	ASN939

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