2FVD
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![BU of 2fvd by Molmil](/molmil-images/mine/2fvd) | Cyclin Dependent Kinase 2 (CDK2) with diaminopyrimidine inhibitor | 分子名称: | (4-AMINO-2-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIMIDIN-5-YL)(2,3-DIFLUORO-6-METHOXYPHENYL)METHANONE, Cell division protein kinase 2 | 著者 | Crowther, R.L, Lukacs, C.M, Kammlott, R.U. | 登録日 | 2006-01-30 | 公開日 | 2006-10-10 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity. J.Med.Chem., 49, 2006
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1XRU
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1NND
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![BU of 1nnd by Molmil](/molmil-images/mine/1nnd) | Arginine 116 is Essential for Nucleic Acid Recognition by the Fingers Domain of Moloney Murine Leukemia Virus Reverse Transcriptase | 分子名称: | Reverse Transcriptase | 著者 | Crowther, R.L, Remeta, D.P, Minetti, C.A, Das, D, Montano, S.P, Georgiadis, M.M. | 登録日 | 2003-01-13 | 公開日 | 2004-01-27 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and energetic characterization of nucleic acid-binding to the fingers domain of Moloney murine leukemia virus reverse transcriptase Proteins, 57, 2004
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6GX5
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![BU of 6gx5 by Molmil](/molmil-images/mine/6gx5) | Narrow Pick Filament from Pick's disease brain | 分子名称: | Microtubule-associated protein tau | 著者 | Falcon, B, Zhang, W, Murzin, A.G, Murshudov, G, Garringer, H.J, Vidal, R, Crowther, R.A, Ghetti, B, Scheres, S.H.W, Goedert, M. | 登録日 | 2018-06-26 | 公開日 | 2018-09-12 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of filaments from Pick's disease reveal a novel tau protein fold. Nature, 561, 2018
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8Q92
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![BU of 8q92 by Molmil](/molmil-images/mine/8q92) | P301S Tau Filaments from the Brains of PS19 Transgenic Mouse Line | 分子名称: | Microtubule-associated protein tau | 著者 | Schweighauser, M, Murzin, A.G, Macdonald, J, Lavenir, I, Crowther, R.A, Scheres, S.H.W, Goedert, M. | 登録日 | 2023-08-19 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau. Acta Neuropathol Commun, 11, 2023
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8Q96
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![BU of 8q96 by Molmil](/molmil-images/mine/8q96) | P301S Tau Filaments from the Brains of Tg2541 Transgenic Mouse Line | 分子名称: | Isoform Tau-E of Microtubule-associated protein tau, Unknown protein | 著者 | Schweighauser, M, Murzin, A.G, Macdonald, J, Lavenir, I, Crowther, R.A, Scheres, S.H.W, Goedert, M. | 登録日 | 2023-08-19 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau. Acta Neuropathol Commun, 11, 2023
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6NWQ
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![BU of 6nwq by Molmil](/molmil-images/mine/6nwq) | Chronic traumatic encephalopathy Type II Tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Falcon, B, Zivanov, J, Zhang, W, Murzin, A.G, Garringer, H.J, Vidal, R, Crowther, R.A, Newell, K.L, Ghetti, B, Goedert, M, Scheres, H.W. | 登録日 | 2019-02-07 | 公開日 | 2019-03-27 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature, 568, 2019
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6QJP
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![BU of 6qjp by Molmil](/molmil-images/mine/6qjp) | Cryo-EM structure of heparin-induced 2N4R tau jagged filaments | 分子名称: | Microtubule-associated protein tau | 著者 | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | 登録日 | 2019-01-24 | 公開日 | 2019-02-20 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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6QJH
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![BU of 6qjh by Molmil](/molmil-images/mine/6qjh) | Cryo-EM structure of heparin-induced 2N4R tau snake filaments | 分子名称: | Microtubule-associated protein tau | 著者 | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | 登録日 | 2019-01-24 | 公開日 | 2019-02-20 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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6QJM
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![BU of 6qjm by Molmil](/molmil-images/mine/6qjm) | Cryo-EM structure of heparin-induced 2N4R tau twister filaments | 分子名称: | Microtubule-associated protein tau | 著者 | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | 登録日 | 2019-01-24 | 公開日 | 2019-02-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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6QJQ
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![BU of 6qjq by Molmil](/molmil-images/mine/6qjq) | Cryo-EM structure of heparin-induced 2N3R tau filaments | 分子名称: | Microtubule-associated protein tau | 著者 | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | 登録日 | 2019-01-24 | 公開日 | 2019-02-20 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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1Z8D
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![BU of 1z8d by Molmil](/molmil-images/mine/1z8d) | Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose | 分子名称: | ADENINE, ADENOSINE MONOPHOSPHATE, Glycogen phosphorylase, ... | 著者 | Lukacs, C.M, Oikonomakos, N.G, Crowther, R.L, Hong, L.N, Kammlott, R.U, Levin, W, Li, S, Liu, C.M, Lucas-McGady, D, Pietranico, S, Reik, L. | 登録日 | 2005-03-30 | 公開日 | 2006-03-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: An intermediate conformation with T-state and R-state features. Proteins, 63, 2006
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6NWP
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![BU of 6nwp by Molmil](/molmil-images/mine/6nwp) | Chronic traumatic encephalopathy Type I Tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Falcon, B, Zivanov, J, Zhang, W, Murzin, A.G, Garringer, H.J, Vidal, R, Crowther, R.A, Newell, K.L, Ghetti, B, Goedert, M, Scheres, H.W. | 登録日 | 2019-02-07 | 公開日 | 2019-03-27 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature, 568, 2019
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1QGT
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1D5M
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![BU of 1d5m by Molmil](/molmil-images/mine/1d5m) | X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDE AND SEB | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ENTEROTOXIN TYPE B, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, ... | 著者 | Swain, A.L, Crowther, R, Kammlott, U. | 登録日 | 1999-10-07 | 公開日 | 2000-06-28 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures. J.Med.Chem., 43, 2000
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1D5X
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![BU of 1d5x by Molmil](/molmil-images/mine/1d5x) | X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH DIPEPTIDE MIMETIC AND SEB | 分子名称: | DIPEPTIDE MIMETIC INHIBITOR, ENTEROTOXIN TYPE B, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN | 著者 | Swain, A, Crowther, R, Kammlott, U. | 登録日 | 1999-10-12 | 公開日 | 2000-06-28 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures. J.Med.Chem., 43, 2000
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1D5Z
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![BU of 1d5z by Molmil](/molmil-images/mine/1d5z) | X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDOMIMETIC AND SEB | 分子名称: | PROTEIN (ENTEROTOXIN TYPE B), PROTEIN (HLA CLASS II HISTOCOMPATIBILITY ANTIGEN), PROTEIN (PEPTIDOMIMETIC INHIBITOR) | 著者 | Swain, A, Crowther, R, Kammlott, U. | 登録日 | 1999-10-12 | 公開日 | 2000-06-28 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures. J.Med.Chem., 43, 2000
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1D6E
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![BU of 1d6e by Molmil](/molmil-images/mine/1d6e) | CRYSTAL STRUCTURE OF HLA-DR4 COMPLEX WITH PEPTIDOMIMETIC AND SEB | 分子名称: | ENTEROTOXIN TYPE B, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, PEPTIDOMIMETIC INHIBITOR | 著者 | Swain, A, Crowther, R, Kammlott, U. | 登録日 | 1999-10-13 | 公開日 | 2000-06-28 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures. J.Med.Chem., 43, 2000
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1C3I
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![BU of 1c3i by Molmil](/molmil-images/mine/1c3i) | HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812 | 分子名称: | 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER, CALCIUM ION, STROMELYSIN-1, ... | 著者 | Steele, D.L, Kammlott, R.U, Crowther, R.L, Birktoft, J.J, Dunten, P, Engler, J.E. | 登録日 | 1999-07-27 | 公開日 | 2000-07-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1. Protein Eng., 13, 2000
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1KHE
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![BU of 1khe by Molmil](/molmil-images/mine/1khe) | PEPCK complex with nonhydrolyzable GTP analog, MAD data | 分子名称: | MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Phosphoenolpyruvate Carboxykinase, ... | 著者 | Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J. | 登録日 | 2001-11-29 | 公開日 | 2002-02-27 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J.Mol.Biol., 316, 2002
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1KHB
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![BU of 1khb by Molmil](/molmil-images/mine/1khb) | PEPCK complex with nonhydrolyzable GTP analog, native data | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, MANGANESE (II) ION, ... | 著者 | Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J. | 登録日 | 2001-11-29 | 公開日 | 2002-02-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.854 Å) | 主引用文献 | Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J.Mol.Biol., 316, 2002
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1KHG
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![BU of 1khg by Molmil](/molmil-images/mine/1khg) | PEPCK | 分子名称: | 1,2-ETHANEDIOL, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... | 著者 | Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J. | 登録日 | 2001-11-29 | 公開日 | 2002-02-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J.Mol.Biol., 316, 2002
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1KHF
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![BU of 1khf by Molmil](/molmil-images/mine/1khf) | PEPCK complex with PEP | 分子名称: | 1,2-ETHANEDIOL, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... | 著者 | Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J. | 登録日 | 2001-11-29 | 公開日 | 2002-02-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J.Mol.Biol., 316, 2002
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5O3T
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![BU of 5o3t by Molmil](/molmil-images/mine/5o3t) | Straight filament in Alzheimer's disease brain | 分子名称: | Microtubule-associated protein tau | 著者 | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | 登録日 | 2017-05-24 | 公開日 | 2017-07-26 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease. Nature, 547, 2017
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5O3L
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![BU of 5o3l by Molmil](/molmil-images/mine/5o3l) | Paired helical filament in Alzheimer's disease brain | 分子名称: | Microtubule-associated protein tau | 著者 | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | 登録日 | 2017-05-24 | 公開日 | 2017-07-26 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease. Nature, 547, 2017
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