8UDT
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![BU of 8udt by Molmil](/molmil-images/mine/8udt) | The X-RAY co-crystal structure of human FGFR3 and KIN-3248 | 分子名称: | 3-[(1-cyclopropyl-4,6-difluoro-1H-benzimidazol-5-yl)ethynyl]-1-[(3R,5R)-5-(methoxymethyl)-1-propanoylpyrrolidin-3-yl]-5-(methylamino)-1H-pyrazole-4-carboxamide, D-MALATE, Fibroblast growth factor receptor 3 | 著者 | Tyhonas, J.S, Arnold, L.D, Cox, J, Franovic, A, Gardiner, E, Grandinetti, K, Kania, R, Kanouni, T, Lardy, M, Li, C, Martin, E.S, Miller, N, Mohan, A, Murphy, E.A, Perez, M, Soroceanu, L, Timple, N, Uryu, S, Womble, S, Kaldor, S.W. | 登録日 | 2023-09-29 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.829 Å) | 主引用文献 | Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations. J.Med.Chem., 67, 2024
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8UDU
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![BU of 8udu by Molmil](/molmil-images/mine/8udu) | The X-RAY co-crystal structure of human FGFR3 and Compound 17 | 分子名称: | 3-[(6-chloro-1-cyclopropyl-1H-benzimidazol-5-yl)ethynyl]-1-[(3S,5S)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1H-pyrazole-4-carboxamide, CHLORIDE ION, Fibroblast growth factor receptor 3 | 著者 | Tyhonas, J.S, Arnold, L.D, Cox, J, Franovic, A, Gardiner, E, Grandinetti, K, Kania, R, Kanouni, T, Lardy, M, Li, C, Martin, E.S, Miller, N, Mohan, A, Murphy, E.A, Perez, M, Soroceanu, L, Timple, N, Uryu, S, Womble, S, Kaldor, S.W. | 登録日 | 2023-09-29 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.737 Å) | 主引用文献 | Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations. J.Med.Chem., 67, 2024
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5OCW
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![BU of 5ocw by Molmil](/molmil-images/mine/5ocw) | Structure of Mycobacterium tuberculosis tryptophan synthase in space group F222 | 分子名称: | 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Tryptophan synthase alpha chain, Tryptophan synthase beta chain | 著者 | Futterer, K, Abrahams, K, Cox, J.A.G, Besra, G.S. | 登録日 | 2017-07-03 | 公開日 | 2017-07-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface. Sci Rep, 7, 2017
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2SAS
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![BU of 2sas by Molmil](/molmil-images/mine/2sas) | |
1HQ5
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![BU of 1hq5 by Molmil](/molmil-images/mine/1hq5) | CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH S-(2-BORONOETHYL)-L-CYSTEINE, AN L-ARGININE ANALOGUE | 分子名称: | ARGINASE 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE | 著者 | Kim, N.N, Cox, J.D, Baggio, R.F, Emig, F.A, Mistry, S.K, Harper, S.L, Speicher, D.W, Morris Jr, S.M, Ash, D.E, Traish, A, Christianson, D.W. | 登録日 | 2000-12-14 | 公開日 | 2001-04-04 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry, 40, 2001
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4W4I
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![BU of 4w4i by Molmil](/molmil-images/mine/4w4i) | |
4W4J
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![BU of 4w4j by Molmil](/molmil-images/mine/4w4j) | |
4W4L
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![BU of 4w4l by Molmil](/molmil-images/mine/4w4l) | |
1Q80
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![BU of 1q80 by Molmil](/molmil-images/mine/1q80) | Solution structure and dynamics of Nereis sarcoplasmic calcium binding protein | 分子名称: | Sarcoplasmic calcium-binding protein | 著者 | Rabah, G, Popescu, R, Cox, J.A, Engelborghs, Y, Craescu, C.T. | 登録日 | 2003-08-20 | 公開日 | 2004-09-21 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and internal dynamics of NSCP, a compact calcium-binding protein. Febs J., 272, 2005
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1ZPG
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![BU of 1zpg by Molmil](/molmil-images/mine/1zpg) | Arginase I covalently modified with propylamine at Q19C | 分子名称: | Arginase 1, MANGANESE (II) ION | 著者 | Colleluori, D.M, Reczkowski, R.S, Emig, F.A, Cama, E, Cox, J.D, Scolnick, L.R, Compher, K, Jude, K, Han, S, Viola, R.E, Christianson, D.W, Ash, D.E. | 登録日 | 2005-05-16 | 公開日 | 2005-12-06 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Probing the role of the hyper-reactive histidine residue of arginase. Arch.Biochem.Biophys., 444, 2005
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1ZPE
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![BU of 1zpe by Molmil](/molmil-images/mine/1zpe) | Arginase I covalently modified with butylamine at Q19C | 分子名称: | Arginase 1, MANGANESE (II) ION | 著者 | Colleluori, D.M, Reczkowski, R.S, Emig, F.A, Cama, E, Cox, J.D, Scolnick, L.R, Compher, K, Jude, K, Han, S, Viola, R.E, Christianson, D.W, Ash, D.E. | 登録日 | 2005-05-16 | 公開日 | 2005-12-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Probing the role of the hyper-reactive histidine residue of arginase. Arch.Biochem.Biophys., 444, 2005
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2X5W
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![BU of 2x5w by Molmil](/molmil-images/mine/2x5w) | X-ray structure of Mycobacterium tuberculosis cytochrome P450 CYP125 in complex with substrate cholest-4-en-3-one | 分子名称: | (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, 1,2-ETHANEDIOL, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Ouellet, H, Guan, S, Johnston, J.B, Chow, E.D, Kells, P.M, Burlingame, A.L, Cox, J.S, Podust, L.M, Ortiz de Montellano, P.R. | 登録日 | 2010-02-10 | 公開日 | 2010-06-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Mycobacterium Tuberculosis Cyp125A1, a Steroid C27 Monooxygenase that Detoxifies Intracellularly Generated Cholest-4-En-3-One. Mol.Microbiol., 77, 2010
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1HQX
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![BU of 1hqx by Molmil](/molmil-images/mine/1hqx) | R308K ARGINASE VARIANT | 分子名称: | ARGINASE, MANGANESE (II) ION | 著者 | Lavulo, L.T, Sossong Jr, T.M, Brigham-Burke, M.R, Doyle, M.L, Cox, J.D, Christianson, D.W, Ash, D.E. | 登録日 | 2000-12-20 | 公開日 | 2001-06-06 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid. J.Biol.Chem., 276, 2001
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1J7R
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![BU of 1j7r by Molmil](/molmil-images/mine/1j7r) | Solution structure and backbone dynamics of the defunct EF-hand domain of Calcium Vector Protein | 分子名称: | Calcium Vector Protein | 著者 | Theret, I, Baladi, S, Cox, J.A, Gallay, J, Sakamoto, H, Craescu, C.T. | 登録日 | 2001-05-18 | 公開日 | 2001-06-06 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and backbone dynamics of the defunct domain of calcium vector protein. Biochemistry, 40, 2001
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1J7Q
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![BU of 1j7q by Molmil](/molmil-images/mine/1j7q) | Solution structure and backbone dynamics of the defunct EF-hand domain of Calcium Vector Protein | 分子名称: | Calcium Vector Protein | 著者 | Theret, I, Baladi, S, Cox, J.A, Gallay, J, Sakamoto, H, Craescu, C.T. | 登録日 | 2001-05-18 | 公開日 | 2001-06-06 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and backbone dynamics of the defunct domain of calcium vector protein. Biochemistry, 40, 2001
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3R1F
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![BU of 3r1f by Molmil](/molmil-images/mine/3r1f) | Crystal structure of a key regulator of virulence in Mycobacterium tuberculosis | 分子名称: | ESX-1 secretion-associated regulator EspR | 著者 | Rosenberg, O.S, Dovey, C, Finer-Moore, J, Stroud, R.M, Cox, J.S. | 登録日 | 2011-03-10 | 公開日 | 2011-08-03 | 最終更新日 | 2011-08-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins. Proc.Natl.Acad.Sci.USA, 108, 2011
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4LWS
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![BU of 4lws by Molmil](/molmil-images/mine/4lws) | EsxA : EsxB (SeMet) hetero-dimer from Thermomonospora curvata | 分子名称: | ACETATE ION, GLYCEROL, Uncharacterized protein | 著者 | Dovala, D.L, Cox, J.S, Stroud, R.M, Rosenberg, O.S. | 登録日 | 2013-07-28 | 公開日 | 2015-02-04 | 最終更新日 | 2016-09-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell(Cambridge,Mass.), 161, 2015
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4Q9N
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![BU of 4q9n by Molmil](/molmil-images/mine/4q9n) | Crystal structure of Chlamydia trachomatis enoyl-ACP reductase (FabI) in complex with NADH and AFN-1252 | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Enoyl-[acyl-carrier-protein] reductase [NADH], N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)propanamide | 著者 | Yao, J, Abdelrahman, Y, Robertson, R.M, Cox, J.V, Belland, R.J, White, S.W, Rock, C.O. | 登録日 | 2014-05-01 | 公開日 | 2014-06-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | 主引用文献 | Type II Fatty Acid Synthesis Is Essential for the Replication of Chlamydia trachomatis. J.Biol.Chem., 289, 2014
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4NH0
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![BU of 4nh0 by Molmil](/molmil-images/mine/4nh0) | Cytoplasmic domain of the Thermomonospora curvata Type VII Secretion ATPase EccC | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell divisionFtsK/SpoIIIE, MAGNESIUM ION, ... | 著者 | Rosenberg, O.S, Cox, J.S, Stroud, R.M, Strauli, N, Dovala, D. | 登録日 | 2013-11-03 | 公開日 | 2015-02-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell(Cambridge,Mass.), 161, 2015
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4LYA
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![BU of 4lya by Molmil](/molmil-images/mine/4lya) | EssC (ATPases 2 and 3) from Geobacillus thermodenitrificans (SeMet) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Uncharacterized protein | 著者 | Dovala, D.L, Bendebury, A, Cox, J.S, Stroud, R.M, Rosenberg, O.S. | 登録日 | 2013-07-30 | 公開日 | 2015-02-04 | 最終更新日 | 2016-09-21 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell(Cambridge,Mass.), 161, 2015
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1M39
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![BU of 1m39 by Molmil](/molmil-images/mine/1m39) | Solution structure of the C-terminal fragment (F86-I165) of the human centrin 2 in calcium saturated form | 分子名称: | Caltractin, isoform 1 | 著者 | Matei, E, Miron, S, Blouquit, Y, Duchambon, P, Durussel, P, Cox, J.A, Craescu, C.T. | 登録日 | 2002-06-27 | 公開日 | 2003-03-25 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain Biochemistry, 42, 2003
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1TBL
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![BU of 1tbl by Molmil](/molmil-images/mine/1tbl) | H141N mutant of rat liver arginase I | 分子名称: | Arginase 1, MANGANESE (II) ION | 著者 | Cama, E, Cox, J.D, Ash, D.E, Christianson, D.W. | 登録日 | 2004-05-20 | 公開日 | 2005-08-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Probing the role of the hyper-reactive histidine residue of arginase. Arch.Biochem.Biophys., 444, 2005
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1TBJ
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![BU of 1tbj by Molmil](/molmil-images/mine/1tbj) | H141A mutant of rat liver arginase I | 分子名称: | Arginase 1, GLYCEROL, MANGANESE (II) ION | 著者 | Cama, E, Cox, J.D, Ash, D.E, Christianson, D.W. | 登録日 | 2004-05-20 | 公開日 | 2005-08-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Probing the role of the hyper-reactive histidine residue of arginase. Arch.Biochem.Biophys., 444, 2005
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1TA1
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![BU of 1ta1 by Molmil](/molmil-images/mine/1ta1) | H141C mutant of rat liver arginase I | 分子名称: | Arginase 1, GLYCEROL, MANGANESE (II) ION | 著者 | Cama, E, Cox, J.D, Ash, D.E, Christianson, D.W. | 登録日 | 2004-05-19 | 公開日 | 2005-08-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Probing the role of the hyper-reactive histidine residue of arginase. Arch.Biochem.Biophys., 444, 2005
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1TBH
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![BU of 1tbh by Molmil](/molmil-images/mine/1tbh) | H141D mutant of rat liver arginase I | 分子名称: | Arginase 1, MANGANESE (II) ION | 著者 | Cama, E, Cox, J.D, Ash, D.E, Christianson, D.W. | 登録日 | 2004-05-20 | 公開日 | 2005-08-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Probing the role of the hyper-reactive histidine residue of arginase. Arch.Biochem.Biophys., 444, 2005
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