4Q9N

Crystal structure of Chlamydia trachomatis enoyl-ACP reductase (FabI) in complex with NADH and AFN-1252

Summary for 4Q9N

Entry DOI	10.2210/pdb4q9n/pdb
Descriptor	Enoyl-[acyl-carrier-protein] reductase [NADH], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)propanamide, ... (4 entities in total)
Functional Keywords	enoyl-acp reductase, nadh, afn-1252, fatty acid synthesis, chlamydia, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Chlamydia trachomatis F/11-96
Total number of polymer chains	8
Total formula weight	264267.34
Authors	Yao, J.,Abdelrahman, Y.,Robertson, R.M.,Cox, J.V.,Belland, R.J.,White, S.W.,Rock, C.O. (deposition date: 2014-05-01, release date: 2014-06-25, Last modification date: 2023-09-20)
Primary citation	Yao, J.,Abdelrahman, Y.M.,Robertson, R.M.,Cox, J.V.,Belland, R.J.,White, S.W.,Rock, C.O. Type II Fatty Acid Synthesis Is Essential for the Replication of Chlamydia trachomatis. J.Biol.Chem., 289:22365-22376, 2014 Cited by PubMed: 24958721 DOI: 10.1074/jbc.M114.584185 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.795 Å)

Structure validation