5OCW

Structure of Mycobacterium tuberculosis tryptophan synthase in space group F222

Summary for 5OCW

• Entry DOI: 10.2210/pdb5ocw/pdb
• Descriptor: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID (3 entities in total)
• Functional Keywords: tryptophan synthesis mycobacterium tuberculosis, electron transport
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); More
• Total number of polymer chains: 24
• Total formula weight: 925268.20

Authors

Futterer, K.,Abrahams, K.,Cox, J.A.G.,Besra, G.S. (deposition date: 2017-07-03, release date: 2017-07-12, Last modification date: 2024-01-17)

• Primary citation: Abrahams, K.A.,Cox, J.A.G.,Futterer, K.,Rullas, J.,Ortega-Muro, F.,Loman, N.J.,Moynihan, P.J.,Perez-Herran, E.,Jimenez, E.,Esquivias, J.,Barros, D.,Ballell, L.,Alemparte, C.,Besra, G.S.; Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.; Sci Rep, 7:9430-9430, 2017; PubMed: 28842600; DOI: 10.1038/s41598-017-09642-y

Experimental method

X-RAY DIFFRACTION (4 Å)