5OCW

Structure of Mycobacterium tuberculosis tryptophan synthase in space group F222

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I... (A, C, E, G, I...)	Tryptophan synthase alpha chain	polymer	290	29921.9	12	UniProt (P9WFY1) Pfam (PF00290)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
2	B, D, F, H, J... (B, D, F, H, J...)	Tryptophan synthase beta chain	polymer	442	46865.5	12	UniProt (P9WFX9) Pfam (PF00291)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
3	AA, BA, CA, DA, EA... (F, H, J, L, N...)	2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID	non-polymer		318.2	12	Chemie (P1T)

Sequence modifications

A, C, E, G, I, K, M, O, Q, S, U, W: 1 - 270 (UniProt: P9WFY1)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

B, D, F, H, J, L, N, P, R, T, V, X: -11 - 410 (UniProt: P9WFX9)

PDB	External Database	Details
Met -31	-	initiating methionine
Gly -30	-	expression tag
Ser -29	-	expression tag
Ser -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
Ser -21	-	expression tag
Ser -20	-	expression tag
Gly -19	-	expression tag
Leu -18	-	expression tag
Val -17	-	expression tag
Pro -16	-	expression tag
Arg -15	-	expression tag
Gly -14	-	expression tag
Ser -13	-	expression tag
His -12	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	24
	Total formula weight	921449.6
Non-Polymers*	Number of molecules	12
	Total formula weight	3818.6
All*	Total formula weight	925268.2

*Water molecules are not included.