Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5OCW

Structure of Mycobacterium tuberculosis tryptophan synthase in space group F222

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000162	biological_process	L-tryptophan biosynthetic process
A	0004834	molecular_function	tryptophan synthase activity
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006568	biological_process	L-tryptophan metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016829	molecular_function	lyase activity
B	0000162	biological_process	L-tryptophan biosynthetic process
B	0004834	molecular_function	tryptophan synthase activity
B	0005737	cellular_component	cytoplasm
B	0006568	biological_process	L-tryptophan metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0016829	molecular_function	lyase activity
B	1901605	biological_process	alpha-amino acid metabolic process
C	0000162	biological_process	L-tryptophan biosynthetic process
C	0004834	molecular_function	tryptophan synthase activity
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006568	biological_process	L-tryptophan metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0016829	molecular_function	lyase activity
D	0000162	biological_process	L-tryptophan biosynthetic process
D	0004834	molecular_function	tryptophan synthase activity
D	0005737	cellular_component	cytoplasm
D	0006568	biological_process	L-tryptophan metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0016829	molecular_function	lyase activity
D	1901605	biological_process	alpha-amino acid metabolic process
E	0000162	biological_process	L-tryptophan biosynthetic process
E	0004834	molecular_function	tryptophan synthase activity
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006568	biological_process	L-tryptophan metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0009073	biological_process	aromatic amino acid family biosynthetic process
E	0016829	molecular_function	lyase activity
F	0000162	biological_process	L-tryptophan biosynthetic process
F	0004834	molecular_function	tryptophan synthase activity
F	0005737	cellular_component	cytoplasm
F	0006568	biological_process	L-tryptophan metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0009073	biological_process	aromatic amino acid family biosynthetic process
F	0016829	molecular_function	lyase activity
F	1901605	biological_process	alpha-amino acid metabolic process
G	0000162	biological_process	L-tryptophan biosynthetic process
G	0004834	molecular_function	tryptophan synthase activity
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006568	biological_process	L-tryptophan metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0009073	biological_process	aromatic amino acid family biosynthetic process
G	0016829	molecular_function	lyase activity
H	0000162	biological_process	L-tryptophan biosynthetic process
H	0004834	molecular_function	tryptophan synthase activity
H	0005737	cellular_component	cytoplasm
H	0006568	biological_process	L-tryptophan metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0009073	biological_process	aromatic amino acid family biosynthetic process
H	0016829	molecular_function	lyase activity
H	1901605	biological_process	alpha-amino acid metabolic process
I	0000162	biological_process	L-tryptophan biosynthetic process
I	0004834	molecular_function	tryptophan synthase activity
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006568	biological_process	L-tryptophan metabolic process
I	0008652	biological_process	amino acid biosynthetic process
I	0009073	biological_process	aromatic amino acid family biosynthetic process
I	0016829	molecular_function	lyase activity
J	0000162	biological_process	L-tryptophan biosynthetic process
J	0004834	molecular_function	tryptophan synthase activity
J	0005737	cellular_component	cytoplasm
J	0006568	biological_process	L-tryptophan metabolic process
J	0008652	biological_process	amino acid biosynthetic process
J	0009073	biological_process	aromatic amino acid family biosynthetic process
J	0016829	molecular_function	lyase activity
J	1901605	biological_process	alpha-amino acid metabolic process
K	0000162	biological_process	L-tryptophan biosynthetic process
K	0004834	molecular_function	tryptophan synthase activity
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006568	biological_process	L-tryptophan metabolic process
K	0008652	biological_process	amino acid biosynthetic process
K	0009073	biological_process	aromatic amino acid family biosynthetic process
K	0016829	molecular_function	lyase activity
L	0000162	biological_process	L-tryptophan biosynthetic process
L	0004834	molecular_function	tryptophan synthase activity
L	0005737	cellular_component	cytoplasm
L	0006568	biological_process	L-tryptophan metabolic process
L	0008652	biological_process	amino acid biosynthetic process
L	0009073	biological_process	aromatic amino acid family biosynthetic process
L	0016829	molecular_function	lyase activity
L	1901605	biological_process	alpha-amino acid metabolic process
M	0000162	biological_process	L-tryptophan biosynthetic process
M	0004834	molecular_function	tryptophan synthase activity
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006568	biological_process	L-tryptophan metabolic process
M	0008652	biological_process	amino acid biosynthetic process
M	0009073	biological_process	aromatic amino acid family biosynthetic process
M	0016829	molecular_function	lyase activity
N	0000162	biological_process	L-tryptophan biosynthetic process
N	0004834	molecular_function	tryptophan synthase activity
N	0005737	cellular_component	cytoplasm
N	0006568	biological_process	L-tryptophan metabolic process
N	0008652	biological_process	amino acid biosynthetic process
N	0009073	biological_process	aromatic amino acid family biosynthetic process
N	0016829	molecular_function	lyase activity
N	1901605	biological_process	alpha-amino acid metabolic process
O	0000162	biological_process	L-tryptophan biosynthetic process
O	0004834	molecular_function	tryptophan synthase activity
O	0005829	cellular_component	cytosol
O	0005886	cellular_component	plasma membrane
O	0006568	biological_process	L-tryptophan metabolic process
O	0008652	biological_process	amino acid biosynthetic process
O	0009073	biological_process	aromatic amino acid family biosynthetic process
O	0016829	molecular_function	lyase activity
P	0000162	biological_process	L-tryptophan biosynthetic process
P	0004834	molecular_function	tryptophan synthase activity
P	0005737	cellular_component	cytoplasm
P	0006568	biological_process	L-tryptophan metabolic process
P	0008652	biological_process	amino acid biosynthetic process
P	0009073	biological_process	aromatic amino acid family biosynthetic process
P	0016829	molecular_function	lyase activity
P	1901605	biological_process	alpha-amino acid metabolic process
Q	0000162	biological_process	L-tryptophan biosynthetic process
Q	0004834	molecular_function	tryptophan synthase activity
Q	0005829	cellular_component	cytosol
Q	0005886	cellular_component	plasma membrane
Q	0006568	biological_process	L-tryptophan metabolic process
Q	0008652	biological_process	amino acid biosynthetic process
Q	0009073	biological_process	aromatic amino acid family biosynthetic process
Q	0016829	molecular_function	lyase activity
R	0000162	biological_process	L-tryptophan biosynthetic process
R	0004834	molecular_function	tryptophan synthase activity
R	0005737	cellular_component	cytoplasm
R	0006568	biological_process	L-tryptophan metabolic process
R	0008652	biological_process	amino acid biosynthetic process
R	0009073	biological_process	aromatic amino acid family biosynthetic process
R	0016829	molecular_function	lyase activity
R	1901605	biological_process	alpha-amino acid metabolic process
S	0000162	biological_process	L-tryptophan biosynthetic process
S	0004834	molecular_function	tryptophan synthase activity
S	0005829	cellular_component	cytosol
S	0005886	cellular_component	plasma membrane
S	0006568	biological_process	L-tryptophan metabolic process
S	0008652	biological_process	amino acid biosynthetic process
S	0009073	biological_process	aromatic amino acid family biosynthetic process
S	0016829	molecular_function	lyase activity
T	0000162	biological_process	L-tryptophan biosynthetic process
T	0004834	molecular_function	tryptophan synthase activity
T	0005737	cellular_component	cytoplasm
T	0006568	biological_process	L-tryptophan metabolic process
T	0008652	biological_process	amino acid biosynthetic process
T	0009073	biological_process	aromatic amino acid family biosynthetic process
T	0016829	molecular_function	lyase activity
T	1901605	biological_process	alpha-amino acid metabolic process
U	0000162	biological_process	L-tryptophan biosynthetic process
U	0004834	molecular_function	tryptophan synthase activity
U	0005829	cellular_component	cytosol
U	0005886	cellular_component	plasma membrane
U	0006568	biological_process	L-tryptophan metabolic process
U	0008652	biological_process	amino acid biosynthetic process
U	0009073	biological_process	aromatic amino acid family biosynthetic process
U	0016829	molecular_function	lyase activity
V	0000162	biological_process	L-tryptophan biosynthetic process
V	0004834	molecular_function	tryptophan synthase activity
V	0005737	cellular_component	cytoplasm
V	0006568	biological_process	L-tryptophan metabolic process
V	0008652	biological_process	amino acid biosynthetic process
V	0009073	biological_process	aromatic amino acid family biosynthetic process
V	0016829	molecular_function	lyase activity
V	1901605	biological_process	alpha-amino acid metabolic process
W	0000162	biological_process	L-tryptophan biosynthetic process
W	0004834	molecular_function	tryptophan synthase activity
W	0005829	cellular_component	cytosol
W	0005886	cellular_component	plasma membrane
W	0006568	biological_process	L-tryptophan metabolic process
W	0008652	biological_process	amino acid biosynthetic process
W	0009073	biological_process	aromatic amino acid family biosynthetic process
W	0016829	molecular_function	lyase activity
X	0000162	biological_process	L-tryptophan biosynthetic process
X	0004834	molecular_function	tryptophan synthase activity
X	0005737	cellular_component	cytoplasm
X	0006568	biological_process	L-tryptophan metabolic process
X	0008652	biological_process	amino acid biosynthetic process
X	0009073	biological_process	aromatic amino acid family biosynthetic process
X	0016829	molecular_function	lyase activity
X	1901605	biological_process	alpha-amino acid metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue P1T B 501

Chain	Residue
B	HIS100
B	THR204
B	GLY246
B	GLY247
B	GLY248
B	SER249
B	ASN250
B	GLY317
B	GLU364
B	SER390
B	LYS101
B	THR124
B	GLY125
B	ALA126
B	GLY127
B	GLN128
B	HIS129
B	LEU180

site_id	AC2
Number of Residues	21
Details	binding site for residue P1T D 501

Chain	Residue
D	HIS100
D	LYS101
D	THR124
D	GLY125
D	ALA126
D	GLY127
D	GLN128
D	HIS129
D	LEU180
D	THR204
D	CYS244
D	GLY246
D	GLY247
D	GLY248
D	SER249
D	ASN250
D	GLY317
D	LEU318
D	GLU364
D	SER390
D	GLY391

site_id	AC3
Number of Residues	18
Details	binding site for residue P1T F 501

Chain	Residue
F	HIS100
F	LYS101
F	THR124
F	GLY125
F	ALA126
F	GLY127
F	GLN128
F	HIS129
F	LEU180
F	THR204
F	GLY246
F	GLY247
F	GLY248
F	SER249
F	ASN250
F	GLY317
F	GLU364
F	SER390

site_id	AC4
Number of Residues	19
Details	binding site for residue P1T H 501

Chain	Residue
H	HIS100
H	LYS101
H	THR124
H	GLY125
H	ALA126
H	GLY127
H	GLN128
H	HIS129
H	LEU180
H	THR204
H	GLY246
H	GLY247
H	GLY248
H	SER249
H	ASN250
H	GLY317
H	GLU364
H	SER390
H	GLY391

site_id	AC5
Number of Residues	19
Details	binding site for residue P1T J 501

Chain	Residue
J	HIS100
J	LYS101
J	THR124
J	GLY125
J	ALA126
J	GLY127
J	GLN128
J	HIS129
J	LEU180
J	THR204
J	CYS244
J	GLY246
J	GLY247
J	GLY248
J	SER249
J	ASN250
J	GLY317
J	GLU364
J	SER390

site_id	AC6
Number of Residues	20
Details	binding site for residue P1T L 501

Chain	Residue
L	ALA126
L	GLY127
L	GLN128
L	HIS129
L	LEU180
L	THR204
L	CYS244
L	GLY246
L	GLY247
L	GLY248
L	SER249
L	ASN250
L	GLY317
L	GLU364
L	SER390
L	GLY391
L	HIS100
L	LYS101
L	THR124
L	GLY125

site_id	AC7
Number of Residues	19
Details	binding site for residue P1T N 501

Chain	Residue
N	HIS100
N	LYS101
N	THR124
N	GLY125
N	ALA126
N	GLY127
N	GLN128
N	HIS129
N	LEU180
N	THR204
N	GLY246
N	GLY247
N	GLY248
N	SER249
N	ASN250
N	GLY317
N	GLU364
N	SER390
N	GLY391

site_id	AC8
Number of Residues	20
Details	binding site for residue P1T P 501

Chain	Residue
P	HIS100
P	LYS101
P	THR124
P	GLY125
P	ALA126
P	GLY127
P	GLN128
P	HIS129
P	LEU180
P	THR204
P	CYS244
P	GLY246
P	GLY247
P	GLY248
P	SER249
P	ASN250
P	GLY317
P	GLU364
P	SER390
P	GLY391

site_id	AC9
Number of Residues	19
Details	binding site for residue P1T R 501

Chain	Residue
R	HIS100
R	LYS101
R	THR124
R	GLY125
R	ALA126
R	GLY127
R	GLN128
R	HIS129
R	LEU180
R	THR204
R	CYS244
R	GLY246
R	GLY247
R	GLY248
R	SER249
R	ASN250
R	GLY317
R	GLU364
R	SER390

site_id	AD1
Number of Residues	20
Details	binding site for residue P1T T 501

Chain	Residue
T	HIS100
T	LYS101
T	THR124
T	GLY125
T	ALA126
T	GLY127
T	GLN128
T	HIS129
T	LEU180
T	THR204
T	GLY246
T	GLY247
T	GLY248
T	SER249
T	ASN250
T	GLY317
T	LEU318
T	GLU364
T	SER390
T	GLY391

site_id	AD2
Number of Residues	18
Details	binding site for residue P1T V 501

Chain	Residue
V	HIS100
V	LYS101
V	THR124
V	GLY125
V	ALA126
V	GLY127
V	GLN128
V	HIS129
V	LEU180
V	THR204
V	GLY246
V	GLY247
V	GLY248
V	SER249
V	ASN250
V	GLY317
V	GLU364
V	SER390

site_id	AD3
Number of Residues	19
Details	binding site for residue P1T X 501

Chain	Residue
X	HIS100
X	LYS101
X	THR124
X	GLY125
X	ALA126
X	GLY127
X	GLN128
X	HIS129
X	LEU180
X	THR204
X	GLY246
X	GLY247
X	GLY248
X	SER249
X	ASN250
X	GLY317
X	GLU364
X	SER390
X	GLY391

site_id	AD4
Number of Residues	11
Details	binding site for Ligand GLN C 228 bound to THR D 118

Chain	Residue
C	ALA224
C	GLN225
C	ALA226
C	ALA227
C	ILE229
C	ALA230
C	GLN231
C	TYR232
D	GLY116
D	LYS117
D	THR118

site_id	AD5
Number of Residues	10
Details	binding site for Ligand GLN W 228 bound to THR X 118

Chain	Residue
W	ALA224
W	GLN225
W	ALA226
W	ALA227
W	ILE229
W	ALA230
W	GLN231
W	TYR232
X	LYS117
X	THR118

site_id	AD6
Number of Residues	35
Details	binding site for Di-peptide ARG F 77 and ARG Q 223

Chain	Residue
F	ALA75
F	THR76
F	LEU78
F	SER79
F	GLN80
F	ARG220
F	ILE221
F	ILE222
F	MET224
F	GLU225
F	ALA226
F	ARG227
F	GLY253
F	ILE254
F	ALA257
F	MET356
F	GLU357
H	ALA138
H	LEU139
H	GLY141
Q	ALA73
Q	ARG74
Q	ALA75
Q	THR76
Q	ALA78
Q	ALA79
Q	LEU80
Q	ARG81
Q	SER222
Q	ALA224
Q	GLN225
Q	ALA226
Q	ALA227
Q	GLU259
Q	GLY263

site_id	AD7
Number of Residues	35
Details	binding site for Di-peptide ARG F 77 and ARG Q 223

Chain	Residue
F	ALA75
F	THR76
F	LEU78
F	SER79
F	GLN80
F	ARG220
F	ILE221
F	ILE222
F	MET224
F	GLU225
F	ALA226
F	ARG227
F	GLY253
F	ILE254
F	ALA257
F	MET356
F	GLU357
H	ALA138
H	LEU139
H	GLY141
Q	ALA73
Q	ARG74
Q	ALA75
Q	THR76
Q	ALA78
Q	ALA79
Q	LEU80
Q	ARG81
Q	SER222
Q	ALA224
Q	GLN225
Q	ALA226
Q	ALA227
Q	GLU259
Q	GLY263

site_id	AD8
Number of Residues	35
Details	binding site for Di-peptide ARG F 77 and ARG Q 223

Chain	Residue
F	ALA75
F	THR76
F	LEU78
F	SER79
F	GLN80
F	ARG220
F	ILE221
F	ILE222
F	MET224
F	GLU225
F	ALA226
F	ARG227
F	GLY253
F	ILE254
F	ALA257
F	MET356
F	GLU357
H	ALA138
H	LEU139
H	GLY141
Q	ALA73
Q	ARG74
Q	ALA75
Q	THR76
Q	ALA78
Q	ALA79
Q	LEU80
Q	ARG81
Q	SER222
Q	ALA224
Q	GLN225
Q	ALA226
Q	ALA227
Q	GLU259
Q	GLY263

site_id	AD9
Number of Residues	25
Details	binding site for Di-peptide GLU I 259 and MET X 356

Chain	Residue
I	ARG223
I	ALA255
I	LEU256
I	THR257
I	GLY258
I	LEU260
I	ALA261
I	ALA262
I	GLY263
V	ALA138
V	LEU139
X	ARG77
X	GLN80
X	PHE255
X	HIS256
X	ALA257
X	PHE258
X	ASP260
X	ASP261
X	ARG335
X	LEU352
X	CYS354
X	ARG355
X	GLU357
X	GLY358

site_id	AE1
Number of Residues	20
Details	binding site for Di-peptide ASP J 239 and PRO T 262

Chain	Residue
J	ARG236
J	PRO238
J	ALA240
J	ASP260
J	ASP261
J	GLY263
J	VAL264
J	ARG265
J	ALA383
J	VAL384
T	ARG236
T	PRO238
T	ALA240
T	ASP260
T	ASP261
T	GLY263
T	VAL264
T	ARG265
T	ALA383
T	VAL384

site_id	AE2
Number of Residues	29
Details	binding site for Di-peptide HIS L 81 and ALA U 255

Chain	Residue
L	LEU78
L	SER79
L	GLN80
L	ALA82
L	VAL241
L	ALA251
L	ILE252
L	GLY253
L	ILE254
L	HIS256
L	ALA257
L	PHE258
L	LEU259
L	VAL267
L	LEU352
U	GLU77
U	ALA78
U	ALA79
U	LEU80
U	GLY82
U	GLY83
U	PRO251
U	ARG252
U	LEU253
U	ARG254
U	LEU256
U	THR257
U	GLY258
U	GLU259

site_id	AE3
Number of Residues	25
Details	binding site for Di-peptide GLU M 259 and MET D 356

Chain	Residue
B	ALA138
B	LEU139
D	ARG77
D	GLN80
D	PHE255
D	HIS256
D	ALA257
D	PHE258
D	ASP260
D	ASP261
D	ARG335
D	LEU352
D	CYS354
D	ARG355
D	GLU357
D	GLY358
M	ARG223
M	ALA255
M	LEU256
M	THR257
M	GLY258
M	LEU260
M	ALA261
M	ALA262
M	GLY263

site_id	AE4
Number of Residues	27
Details	binding site for Di-peptide GLY R 141 and ALA G 224

Chain	Residue
G	ILE138
G	PRO139
G	ASP140
G	ALA142
G	GLN143
G	SER222
G	ARG223
G	GLN225
G	ALA226
G	ALA227
G	GLN228
H	HIS18
H	GLY27
H	ARG28
H	TYR29
R	CYS137
R	ALA138
R	LEU139
R	LEU140
R	LEU142
R	ARG220
R	ILE221
R	ILE222
R	GLY223
R	GLU225
R	ALA226
R	VAL228

site_id	AE5
Number of Residues	33
Details	binding site for Di-peptide ARG T 77 and ARG G 223

Chain	Residue
G	ALA73
G	ARG74
G	ALA75
G	THR76
G	ALA78
G	ALA79
G	LEU80
G	ARG81
G	SER222
G	ALA224
G	GLN225
G	ALA226
G	ALA227
G	GLU259
R	ALA138
R	LEU139
T	ALA75
T	THR76
T	LEU78
T	SER79
T	ARG220
T	ILE221
T	ILE222
T	MET224
T	GLU225
T	ALA226
T	ARG227
T	GLY253
T	ILE254
T	ALA257
T	ARG355
T	MET356
T	GLU357

site_id	AE6
Number of Residues	33
Details	binding site for Di-peptide ARG T 77 and ARG G 223

Chain	Residue
G	ALA73
G	ARG74
G	ALA75
G	THR76
G	ALA78
G	ALA79
G	LEU80
G	ARG81
G	SER222
G	ALA224
G	GLN225
G	ALA226
G	ALA227
G	GLU259
R	ALA138
R	LEU139
T	ALA75
T	THR76
T	LEU78
T	SER79
T	ARG220
T	ILE221
T	ILE222
T	MET224
T	GLU225
T	ALA226
T	ARG227
T	GLY253
T	ILE254
T	ALA257
T	ARG355
T	MET356
T	GLU357

site_id	AE7
Number of Residues	33
Details	binding site for Di-peptide ARG T 77 and ARG G 223

Chain	Residue
G	ALA73
G	ARG74
G	ALA75
G	THR76
G	ALA78
G	ALA79
G	LEU80
G	ARG81
G	SER222
G	ALA224
G	GLN225
G	ALA226
G	ALA227
G	GLU259
R	ALA138
R	LEU139
T	ALA75
T	THR76
T	LEU78
T	SER79
T	ARG220
T	ILE221
T	ILE222
T	MET224
T	GLU225
T	ALA226
T	ARG227
T	GLY253
T	ILE254
T	ALA257
T	ARG355
T	MET356
T	GLU357

site_id	AE8
Number of Residues	35
Details	binding site for Di-peptide ARG V 77 and ARG W 223

Chain	Residue
V	ALA75
V	THR76
V	LEU78
V	SER79
V	GLN80
V	ARG220
V	ILE221
V	ILE222
V	MET224
V	GLU225
V	ALA226
V	ARG227
V	GLY253
V	ILE254
V	ALA257
V	MET356
V	MET356
V	GLU357
W	ALA73
W	ARG74
W	ALA75
W	THR76
W	ALA78
W	ALA79
W	LEU80
W	ARG81
W	SER222
W	ALA224
W	GLN225
W	ALA226
W	ALA227
W	GLU259
X	ALA138
X	LEU139
X	GLY141

site_id	AE9
Number of Residues	35
Details	binding site for Di-peptide ARG V 77 and ARG W 223

Chain	Residue
V	ALA75
V	THR76
V	LEU78
V	SER79
V	GLN80
V	ARG220
V	ILE221
V	ILE222
V	MET224
V	GLU225
V	ALA226
V	ARG227
V	GLY253
V	ILE254
V	ALA257
V	MET356
V	MET356
V	GLU357
W	ALA73
W	ARG74
W	ALA75
W	THR76
W	ALA78
W	ALA79
W	LEU80
W	ARG81
W	SER222
W	ALA224
W	GLN225
W	ALA226
W	ALA227
W	GLU259
X	ALA138
X	LEU139
X	GLY141

site_id	AF1
Number of Residues	35
Details	binding site for Di-peptide ARG V 77 and ARG W 223

Chain	Residue
V	ALA75
V	THR76
V	LEU78
V	SER79
V	GLN80
V	ARG220
V	ILE221
V	ILE222
V	MET224
V	GLU225
V	ALA226
V	ARG227
V	GLY253
V	ILE254
V	ALA257
V	MET356
V	MET356
V	GLU357
W	ALA73
W	ARG74
W	ALA75
W	THR76
W	ALA78
W	ALA79
W	LEU80
W	ARG81
W	SER222
W	ALA224
W	GLN225
W	ALA226
W	ALA227
W	GLU259
X	ALA138
X	LEU139
X	GLY141

site_id	AF2
Number of Residues	32
Details	binding site for Di-peptide GLY X 141 and ALA W 224

Chain	Residue
V	ARG77
W	ILE138
W	PRO139
W	ASP140
W	ALA142
W	GLN143
W	SER222
W	ARG223
W	GLN225
W	ALA226
W	ALA227
W	GLN228
X	HIS18
X	GLY27
X	ARG28
X	TYR29
X	ARG113
X	CYS137
X	ALA138
X	LEU139
X	LEU140
X	LEU142
X	LEU142
X	ASP143
X	ARG220
X	ILE221
X	ILE222
X	GLY223
X	GLU225
X	ALA226
X	ARG227
X	VAL228

Functional Information from PROSITE/UniProt

site_id	PS00167
Number of Residues	14
Details	TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IEVGvPYSDPGMDG

Chain	Residue	Details
A	ILE56-GLY69

site_id	PS00168
Number of Residues	15
Details	TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LnHtGSHKiNnvLgQ

Chain	Residue	Details
B	LEU94-GLN108

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"HAMAP-Rule","id":"MF_00133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)