5OCW
Structure of Mycobacterium tuberculosis tryptophan synthase in space group F222
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | tryptophan biosynthetic process |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006568 | biological_process | tryptophan metabolic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000162 | biological_process | tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006568 | biological_process | tryptophan metabolic process |
| B | 0016829 | molecular_function | lyase activity |
| C | 0000162 | biological_process | tryptophan biosynthetic process |
| C | 0004834 | molecular_function | tryptophan synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006568 | biological_process | tryptophan metabolic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0000162 | biological_process | tryptophan biosynthetic process |
| D | 0004834 | molecular_function | tryptophan synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006568 | biological_process | tryptophan metabolic process |
| D | 0016829 | molecular_function | lyase activity |
| E | 0000162 | biological_process | tryptophan biosynthetic process |
| E | 0004834 | molecular_function | tryptophan synthase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006568 | biological_process | tryptophan metabolic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0000162 | biological_process | tryptophan biosynthetic process |
| F | 0004834 | molecular_function | tryptophan synthase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006568 | biological_process | tryptophan metabolic process |
| F | 0016829 | molecular_function | lyase activity |
| G | 0000162 | biological_process | tryptophan biosynthetic process |
| G | 0004834 | molecular_function | tryptophan synthase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006568 | biological_process | tryptophan metabolic process |
| G | 0016829 | molecular_function | lyase activity |
| H | 0000162 | biological_process | tryptophan biosynthetic process |
| H | 0004834 | molecular_function | tryptophan synthase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006568 | biological_process | tryptophan metabolic process |
| H | 0016829 | molecular_function | lyase activity |
| I | 0000162 | biological_process | tryptophan biosynthetic process |
| I | 0004834 | molecular_function | tryptophan synthase activity |
| I | 0005829 | cellular_component | cytosol |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0006568 | biological_process | tryptophan metabolic process |
| I | 0016829 | molecular_function | lyase activity |
| J | 0000162 | biological_process | tryptophan biosynthetic process |
| J | 0004834 | molecular_function | tryptophan synthase activity |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006568 | biological_process | tryptophan metabolic process |
| J | 0016829 | molecular_function | lyase activity |
| K | 0000162 | biological_process | tryptophan biosynthetic process |
| K | 0004834 | molecular_function | tryptophan synthase activity |
| K | 0005829 | cellular_component | cytosol |
| K | 0005886 | cellular_component | plasma membrane |
| K | 0006568 | biological_process | tryptophan metabolic process |
| K | 0016829 | molecular_function | lyase activity |
| L | 0000162 | biological_process | tryptophan biosynthetic process |
| L | 0004834 | molecular_function | tryptophan synthase activity |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006568 | biological_process | tryptophan metabolic process |
| L | 0016829 | molecular_function | lyase activity |
| M | 0000162 | biological_process | tryptophan biosynthetic process |
| M | 0004834 | molecular_function | tryptophan synthase activity |
| M | 0005829 | cellular_component | cytosol |
| M | 0005886 | cellular_component | plasma membrane |
| M | 0006568 | biological_process | tryptophan metabolic process |
| M | 0016829 | molecular_function | lyase activity |
| N | 0000162 | biological_process | tryptophan biosynthetic process |
| N | 0004834 | molecular_function | tryptophan synthase activity |
| N | 0005737 | cellular_component | cytoplasm |
| N | 0006568 | biological_process | tryptophan metabolic process |
| N | 0016829 | molecular_function | lyase activity |
| O | 0000162 | biological_process | tryptophan biosynthetic process |
| O | 0004834 | molecular_function | tryptophan synthase activity |
| O | 0005829 | cellular_component | cytosol |
| O | 0005886 | cellular_component | plasma membrane |
| O | 0006568 | biological_process | tryptophan metabolic process |
| O | 0016829 | molecular_function | lyase activity |
| P | 0000162 | biological_process | tryptophan biosynthetic process |
| P | 0004834 | molecular_function | tryptophan synthase activity |
| P | 0005737 | cellular_component | cytoplasm |
| P | 0006568 | biological_process | tryptophan metabolic process |
| P | 0016829 | molecular_function | lyase activity |
| Q | 0000162 | biological_process | tryptophan biosynthetic process |
| Q | 0004834 | molecular_function | tryptophan synthase activity |
| Q | 0005829 | cellular_component | cytosol |
| Q | 0005886 | cellular_component | plasma membrane |
| Q | 0006568 | biological_process | tryptophan metabolic process |
| Q | 0016829 | molecular_function | lyase activity |
| R | 0000162 | biological_process | tryptophan biosynthetic process |
| R | 0004834 | molecular_function | tryptophan synthase activity |
| R | 0005737 | cellular_component | cytoplasm |
| R | 0006568 | biological_process | tryptophan metabolic process |
| R | 0016829 | molecular_function | lyase activity |
| S | 0000162 | biological_process | tryptophan biosynthetic process |
| S | 0004834 | molecular_function | tryptophan synthase activity |
| S | 0005829 | cellular_component | cytosol |
| S | 0005886 | cellular_component | plasma membrane |
| S | 0006568 | biological_process | tryptophan metabolic process |
| S | 0016829 | molecular_function | lyase activity |
| T | 0000162 | biological_process | tryptophan biosynthetic process |
| T | 0004834 | molecular_function | tryptophan synthase activity |
| T | 0005737 | cellular_component | cytoplasm |
| T | 0006568 | biological_process | tryptophan metabolic process |
| T | 0016829 | molecular_function | lyase activity |
| U | 0000162 | biological_process | tryptophan biosynthetic process |
| U | 0004834 | molecular_function | tryptophan synthase activity |
| U | 0005829 | cellular_component | cytosol |
| U | 0005886 | cellular_component | plasma membrane |
| U | 0006568 | biological_process | tryptophan metabolic process |
| U | 0016829 | molecular_function | lyase activity |
| V | 0000162 | biological_process | tryptophan biosynthetic process |
| V | 0004834 | molecular_function | tryptophan synthase activity |
| V | 0005737 | cellular_component | cytoplasm |
| V | 0006568 | biological_process | tryptophan metabolic process |
| V | 0016829 | molecular_function | lyase activity |
| W | 0000162 | biological_process | tryptophan biosynthetic process |
| W | 0004834 | molecular_function | tryptophan synthase activity |
| W | 0005829 | cellular_component | cytosol |
| W | 0005886 | cellular_component | plasma membrane |
| W | 0006568 | biological_process | tryptophan metabolic process |
| W | 0016829 | molecular_function | lyase activity |
| X | 0000162 | biological_process | tryptophan biosynthetic process |
| X | 0004834 | molecular_function | tryptophan synthase activity |
| X | 0005737 | cellular_component | cytoplasm |
| X | 0006568 | biological_process | tryptophan metabolic process |
| X | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue P1T B 501 |
| Chain | Residue |
| B | HIS100 |
| B | THR204 |
| B | GLY246 |
| B | GLY247 |
| B | GLY248 |
| B | SER249 |
| B | ASN250 |
| B | GLY317 |
| B | GLU364 |
| B | SER390 |
| B | LYS101 |
| B | THR124 |
| B | GLY125 |
| B | ALA126 |
| B | GLY127 |
| B | GLN128 |
| B | HIS129 |
| B | LEU180 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue P1T D 501 |
| Chain | Residue |
| D | HIS100 |
| D | LYS101 |
| D | THR124 |
| D | GLY125 |
| D | ALA126 |
| D | GLY127 |
| D | GLN128 |
| D | HIS129 |
| D | LEU180 |
| D | THR204 |
| D | CYS244 |
| D | GLY246 |
| D | GLY247 |
| D | GLY248 |
| D | SER249 |
| D | ASN250 |
| D | GLY317 |
| D | LEU318 |
| D | GLU364 |
| D | SER390 |
| D | GLY391 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue P1T F 501 |
| Chain | Residue |
| F | HIS100 |
| F | LYS101 |
| F | THR124 |
| F | GLY125 |
| F | ALA126 |
| F | GLY127 |
| F | GLN128 |
| F | HIS129 |
| F | LEU180 |
| F | THR204 |
| F | GLY246 |
| F | GLY247 |
| F | GLY248 |
| F | SER249 |
| F | ASN250 |
| F | GLY317 |
| F | GLU364 |
| F | SER390 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue P1T H 501 |
| Chain | Residue |
| H | HIS100 |
| H | LYS101 |
| H | THR124 |
| H | GLY125 |
| H | ALA126 |
| H | GLY127 |
| H | GLN128 |
| H | HIS129 |
| H | LEU180 |
| H | THR204 |
| H | GLY246 |
| H | GLY247 |
| H | GLY248 |
| H | SER249 |
| H | ASN250 |
| H | GLY317 |
| H | GLU364 |
| H | SER390 |
| H | GLY391 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue P1T J 501 |
| Chain | Residue |
| J | HIS100 |
| J | LYS101 |
| J | THR124 |
| J | GLY125 |
| J | ALA126 |
| J | GLY127 |
| J | GLN128 |
| J | HIS129 |
| J | LEU180 |
| J | THR204 |
| J | CYS244 |
| J | GLY246 |
| J | GLY247 |
| J | GLY248 |
| J | SER249 |
| J | ASN250 |
| J | GLY317 |
| J | GLU364 |
| J | SER390 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | binding site for residue P1T L 501 |
| Chain | Residue |
| L | ALA126 |
| L | GLY127 |
| L | GLN128 |
| L | HIS129 |
| L | LEU180 |
| L | THR204 |
| L | CYS244 |
| L | GLY246 |
| L | GLY247 |
| L | GLY248 |
| L | SER249 |
| L | ASN250 |
| L | GLY317 |
| L | GLU364 |
| L | SER390 |
| L | GLY391 |
| L | HIS100 |
| L | LYS101 |
| L | THR124 |
| L | GLY125 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | binding site for residue P1T N 501 |
| Chain | Residue |
| N | HIS100 |
| N | LYS101 |
| N | THR124 |
| N | GLY125 |
| N | ALA126 |
| N | GLY127 |
| N | GLN128 |
| N | HIS129 |
| N | LEU180 |
| N | THR204 |
| N | GLY246 |
| N | GLY247 |
| N | GLY248 |
| N | SER249 |
| N | ASN250 |
| N | GLY317 |
| N | GLU364 |
| N | SER390 |
| N | GLY391 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | binding site for residue P1T P 501 |
| Chain | Residue |
| P | HIS100 |
| P | LYS101 |
| P | THR124 |
| P | GLY125 |
| P | ALA126 |
| P | GLY127 |
| P | GLN128 |
| P | HIS129 |
| P | LEU180 |
| P | THR204 |
| P | CYS244 |
| P | GLY246 |
| P | GLY247 |
| P | GLY248 |
| P | SER249 |
| P | ASN250 |
| P | GLY317 |
| P | GLU364 |
| P | SER390 |
| P | GLY391 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | binding site for residue P1T R 501 |
| Chain | Residue |
| R | HIS100 |
| R | LYS101 |
| R | THR124 |
| R | GLY125 |
| R | ALA126 |
| R | GLY127 |
| R | GLN128 |
| R | HIS129 |
| R | LEU180 |
| R | THR204 |
| R | CYS244 |
| R | GLY246 |
| R | GLY247 |
| R | GLY248 |
| R | SER249 |
| R | ASN250 |
| R | GLY317 |
| R | GLU364 |
| R | SER390 |
| site_id | AD1 |
| Number of Residues | 20 |
| Details | binding site for residue P1T T 501 |
| Chain | Residue |
| T | HIS100 |
| T | LYS101 |
| T | THR124 |
| T | GLY125 |
| T | ALA126 |
| T | GLY127 |
| T | GLN128 |
| T | HIS129 |
| T | LEU180 |
| T | THR204 |
| T | GLY246 |
| T | GLY247 |
| T | GLY248 |
| T | SER249 |
| T | ASN250 |
| T | GLY317 |
| T | LEU318 |
| T | GLU364 |
| T | SER390 |
| T | GLY391 |
| site_id | AD2 |
| Number of Residues | 18 |
| Details | binding site for residue P1T V 501 |
| Chain | Residue |
| V | HIS100 |
| V | LYS101 |
| V | THR124 |
| V | GLY125 |
| V | ALA126 |
| V | GLY127 |
| V | GLN128 |
| V | HIS129 |
| V | LEU180 |
| V | THR204 |
| V | GLY246 |
| V | GLY247 |
| V | GLY248 |
| V | SER249 |
| V | ASN250 |
| V | GLY317 |
| V | GLU364 |
| V | SER390 |
| site_id | AD3 |
| Number of Residues | 19 |
| Details | binding site for residue P1T X 501 |
| Chain | Residue |
| X | HIS100 |
| X | LYS101 |
| X | THR124 |
| X | GLY125 |
| X | ALA126 |
| X | GLY127 |
| X | GLN128 |
| X | HIS129 |
| X | LEU180 |
| X | THR204 |
| X | GLY246 |
| X | GLY247 |
| X | GLY248 |
| X | SER249 |
| X | ASN250 |
| X | GLY317 |
| X | GLU364 |
| X | SER390 |
| X | GLY391 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for Ligand GLN C 228 bound to THR D 118 |
| Chain | Residue |
| C | ALA224 |
| C | GLN225 |
| C | ALA226 |
| C | ALA227 |
| C | ILE229 |
| C | ALA230 |
| C | GLN231 |
| C | TYR232 |
| D | GLY116 |
| D | LYS117 |
| D | THR118 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for Ligand GLN W 228 bound to THR X 118 |
| Chain | Residue |
| W | ALA224 |
| W | GLN225 |
| W | ALA226 |
| W | ALA227 |
| W | ILE229 |
| W | ALA230 |
| W | GLN231 |
| W | TYR232 |
| X | LYS117 |
| X | THR118 |
| site_id | AD6 |
| Number of Residues | 35 |
| Details | binding site for Di-peptide ARG F 77 and ARG Q 223 |
| Chain | Residue |
| F | ALA75 |
| F | THR76 |
| F | LEU78 |
| F | SER79 |
| F | GLN80 |
| F | ARG220 |
| F | ILE221 |
| F | ILE222 |
| F | MET224 |
| F | GLU225 |
| F | ALA226 |
| F | ARG227 |
| F | GLY253 |
| F | ILE254 |
| F | ALA257 |
| F | MET356 |
| F | GLU357 |
| H | ALA138 |
| H | LEU139 |
| H | GLY141 |
| Q | ALA73 |
| Q | ARG74 |
| Q | ALA75 |
| Q | THR76 |
| Q | ALA78 |
| Q | ALA79 |
| Q | LEU80 |
| Q | ARG81 |
| Q | SER222 |
| Q | ALA224 |
| Q | GLN225 |
| Q | ALA226 |
| Q | ALA227 |
| Q | GLU259 |
| Q | GLY263 |
| site_id | AD7 |
| Number of Residues | 35 |
| Details | binding site for Di-peptide ARG F 77 and ARG Q 223 |
| Chain | Residue |
| F | ALA75 |
| F | THR76 |
| F | LEU78 |
| F | SER79 |
| F | GLN80 |
| F | ARG220 |
| F | ILE221 |
| F | ILE222 |
| F | MET224 |
| F | GLU225 |
| F | ALA226 |
| F | ARG227 |
| F | GLY253 |
| F | ILE254 |
| F | ALA257 |
| F | MET356 |
| F | GLU357 |
| H | ALA138 |
| H | LEU139 |
| H | GLY141 |
| Q | ALA73 |
| Q | ARG74 |
| Q | ALA75 |
| Q | THR76 |
| Q | ALA78 |
| Q | ALA79 |
| Q | LEU80 |
| Q | ARG81 |
| Q | SER222 |
| Q | ALA224 |
| Q | GLN225 |
| Q | ALA226 |
| Q | ALA227 |
| Q | GLU259 |
| Q | GLY263 |
| site_id | AD8 |
| Number of Residues | 35 |
| Details | binding site for Di-peptide ARG F 77 and ARG Q 223 |
| Chain | Residue |
| F | ALA75 |
| F | THR76 |
| F | LEU78 |
| F | SER79 |
| F | GLN80 |
| F | ARG220 |
| F | ILE221 |
| F | ILE222 |
| F | MET224 |
| F | GLU225 |
| F | ALA226 |
| F | ARG227 |
| F | GLY253 |
| F | ILE254 |
| F | ALA257 |
| F | MET356 |
| F | GLU357 |
| H | ALA138 |
| H | LEU139 |
| H | GLY141 |
| Q | ALA73 |
| Q | ARG74 |
| Q | ALA75 |
| Q | THR76 |
| Q | ALA78 |
| Q | ALA79 |
| Q | LEU80 |
| Q | ARG81 |
| Q | SER222 |
| Q | ALA224 |
| Q | GLN225 |
| Q | ALA226 |
| Q | ALA227 |
| Q | GLU259 |
| Q | GLY263 |
| site_id | AD9 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide GLU I 259 and MET X 356 |
| Chain | Residue |
| I | ARG223 |
| I | ALA255 |
| I | LEU256 |
| I | THR257 |
| I | GLY258 |
| I | LEU260 |
| I | ALA261 |
| I | ALA262 |
| I | GLY263 |
| V | ALA138 |
| V | LEU139 |
| X | ARG77 |
| X | GLN80 |
| X | PHE255 |
| X | HIS256 |
| X | ALA257 |
| X | PHE258 |
| X | ASP260 |
| X | ASP261 |
| X | ARG335 |
| X | LEU352 |
| X | CYS354 |
| X | ARG355 |
| X | GLU357 |
| X | GLY358 |
| site_id | AE1 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide ASP J 239 and PRO T 262 |
| Chain | Residue |
| J | ARG236 |
| J | PRO238 |
| J | ALA240 |
| J | ASP260 |
| J | ASP261 |
| J | GLY263 |
| J | VAL264 |
| J | ARG265 |
| J | ALA383 |
| J | VAL384 |
| T | ARG236 |
| T | PRO238 |
| T | ALA240 |
| T | ASP260 |
| T | ASP261 |
| T | GLY263 |
| T | VAL264 |
| T | ARG265 |
| T | ALA383 |
| T | VAL384 |
| site_id | AE2 |
| Number of Residues | 29 |
| Details | binding site for Di-peptide HIS L 81 and ALA U 255 |
| Chain | Residue |
| L | LEU78 |
| L | SER79 |
| L | GLN80 |
| L | ALA82 |
| L | VAL241 |
| L | ALA251 |
| L | ILE252 |
| L | GLY253 |
| L | ILE254 |
| L | HIS256 |
| L | ALA257 |
| L | PHE258 |
| L | LEU259 |
| L | VAL267 |
| L | LEU352 |
| U | GLU77 |
| U | ALA78 |
| U | ALA79 |
| U | LEU80 |
| U | GLY82 |
| U | GLY83 |
| U | PRO251 |
| U | ARG252 |
| U | LEU253 |
| U | ARG254 |
| U | LEU256 |
| U | THR257 |
| U | GLY258 |
| U | GLU259 |
| site_id | AE3 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide GLU M 259 and MET D 356 |
| Chain | Residue |
| B | ALA138 |
| B | LEU139 |
| D | ARG77 |
| D | GLN80 |
| D | PHE255 |
| D | HIS256 |
| D | ALA257 |
| D | PHE258 |
| D | ASP260 |
| D | ASP261 |
| D | ARG335 |
| D | LEU352 |
| D | CYS354 |
| D | ARG355 |
| D | GLU357 |
| D | GLY358 |
| M | ARG223 |
| M | ALA255 |
| M | LEU256 |
| M | THR257 |
| M | GLY258 |
| M | LEU260 |
| M | ALA261 |
| M | ALA262 |
| M | GLY263 |
| site_id | AE4 |
| Number of Residues | 27 |
| Details | binding site for Di-peptide GLY R 141 and ALA G 224 |
| Chain | Residue |
| G | ILE138 |
| G | PRO139 |
| G | ASP140 |
| G | ALA142 |
| G | GLN143 |
| G | SER222 |
| G | ARG223 |
| G | GLN225 |
| G | ALA226 |
| G | ALA227 |
| G | GLN228 |
| H | HIS18 |
| H | GLY27 |
| H | ARG28 |
| H | TYR29 |
| R | CYS137 |
| R | ALA138 |
| R | LEU139 |
| R | LEU140 |
| R | LEU142 |
| R | ARG220 |
| R | ILE221 |
| R | ILE222 |
| R | GLY223 |
| R | GLU225 |
| R | ALA226 |
| R | VAL228 |
| site_id | AE5 |
| Number of Residues | 33 |
| Details | binding site for Di-peptide ARG T 77 and ARG G 223 |
| Chain | Residue |
| G | ALA73 |
| G | ARG74 |
| G | ALA75 |
| G | THR76 |
| G | ALA78 |
| G | ALA79 |
| G | LEU80 |
| G | ARG81 |
| G | SER222 |
| G | ALA224 |
| G | GLN225 |
| G | ALA226 |
| G | ALA227 |
| G | GLU259 |
| R | ALA138 |
| R | LEU139 |
| T | ALA75 |
| T | THR76 |
| T | LEU78 |
| T | SER79 |
| T | ARG220 |
| T | ILE221 |
| T | ILE222 |
| T | MET224 |
| T | GLU225 |
| T | ALA226 |
| T | ARG227 |
| T | GLY253 |
| T | ILE254 |
| T | ALA257 |
| T | ARG355 |
| T | MET356 |
| T | GLU357 |
| site_id | AE6 |
| Number of Residues | 33 |
| Details | binding site for Di-peptide ARG T 77 and ARG G 223 |
| Chain | Residue |
| G | ALA73 |
| G | ARG74 |
| G | ALA75 |
| G | THR76 |
| G | ALA78 |
| G | ALA79 |
| G | LEU80 |
| G | ARG81 |
| G | SER222 |
| G | ALA224 |
| G | GLN225 |
| G | ALA226 |
| G | ALA227 |
| G | GLU259 |
| R | ALA138 |
| R | LEU139 |
| T | ALA75 |
| T | THR76 |
| T | LEU78 |
| T | SER79 |
| T | ARG220 |
| T | ILE221 |
| T | ILE222 |
| T | MET224 |
| T | GLU225 |
| T | ALA226 |
| T | ARG227 |
| T | GLY253 |
| T | ILE254 |
| T | ALA257 |
| T | ARG355 |
| T | MET356 |
| T | GLU357 |
| site_id | AE7 |
| Number of Residues | 33 |
| Details | binding site for Di-peptide ARG T 77 and ARG G 223 |
| Chain | Residue |
| G | ALA73 |
| G | ARG74 |
| G | ALA75 |
| G | THR76 |
| G | ALA78 |
| G | ALA79 |
| G | LEU80 |
| G | ARG81 |
| G | SER222 |
| G | ALA224 |
| G | GLN225 |
| G | ALA226 |
| G | ALA227 |
| G | GLU259 |
| R | ALA138 |
| R | LEU139 |
| T | ALA75 |
| T | THR76 |
| T | LEU78 |
| T | SER79 |
| T | ARG220 |
| T | ILE221 |
| T | ILE222 |
| T | MET224 |
| T | GLU225 |
| T | ALA226 |
| T | ARG227 |
| T | GLY253 |
| T | ILE254 |
| T | ALA257 |
| T | ARG355 |
| T | MET356 |
| T | GLU357 |
| site_id | AE8 |
| Number of Residues | 35 |
| Details | binding site for Di-peptide ARG V 77 and ARG W 223 |
| Chain | Residue |
| V | ALA75 |
| V | THR76 |
| V | LEU78 |
| V | SER79 |
| V | GLN80 |
| V | ARG220 |
| V | ILE221 |
| V | ILE222 |
| V | MET224 |
| V | GLU225 |
| V | ALA226 |
| V | ARG227 |
| V | GLY253 |
| V | ILE254 |
| V | ALA257 |
| V | MET356 |
| V | MET356 |
| V | GLU357 |
| W | ALA73 |
| W | ARG74 |
| W | ALA75 |
| W | THR76 |
| W | ALA78 |
| W | ALA79 |
| W | LEU80 |
| W | ARG81 |
| W | SER222 |
| W | ALA224 |
| W | GLN225 |
| W | ALA226 |
| W | ALA227 |
| W | GLU259 |
| X | ALA138 |
| X | LEU139 |
| X | GLY141 |
| site_id | AE9 |
| Number of Residues | 35 |
| Details | binding site for Di-peptide ARG V 77 and ARG W 223 |
| Chain | Residue |
| V | ALA75 |
| V | THR76 |
| V | LEU78 |
| V | SER79 |
| V | GLN80 |
| V | ARG220 |
| V | ILE221 |
| V | ILE222 |
| V | MET224 |
| V | GLU225 |
| V | ALA226 |
| V | ARG227 |
| V | GLY253 |
| V | ILE254 |
| V | ALA257 |
| V | MET356 |
| V | MET356 |
| V | GLU357 |
| W | ALA73 |
| W | ARG74 |
| W | ALA75 |
| W | THR76 |
| W | ALA78 |
| W | ALA79 |
| W | LEU80 |
| W | ARG81 |
| W | SER222 |
| W | ALA224 |
| W | GLN225 |
| W | ALA226 |
| W | ALA227 |
| W | GLU259 |
| X | ALA138 |
| X | LEU139 |
| X | GLY141 |
| site_id | AF1 |
| Number of Residues | 35 |
| Details | binding site for Di-peptide ARG V 77 and ARG W 223 |
| Chain | Residue |
| V | ALA75 |
| V | THR76 |
| V | LEU78 |
| V | SER79 |
| V | GLN80 |
| V | ARG220 |
| V | ILE221 |
| V | ILE222 |
| V | MET224 |
| V | GLU225 |
| V | ALA226 |
| V | ARG227 |
| V | GLY253 |
| V | ILE254 |
| V | ALA257 |
| V | MET356 |
| V | MET356 |
| V | GLU357 |
| W | ALA73 |
| W | ARG74 |
| W | ALA75 |
| W | THR76 |
| W | ALA78 |
| W | ALA79 |
| W | LEU80 |
| W | ARG81 |
| W | SER222 |
| W | ALA224 |
| W | GLN225 |
| W | ALA226 |
| W | ALA227 |
| W | GLU259 |
| X | ALA138 |
| X | LEU139 |
| X | GLY141 |
| site_id | AF2 |
| Number of Residues | 32 |
| Details | binding site for Di-peptide GLY X 141 and ALA W 224 |
| Chain | Residue |
| V | ARG77 |
| W | ILE138 |
| W | PRO139 |
| W | ASP140 |
| W | ALA142 |
| W | GLN143 |
| W | SER222 |
| W | ARG223 |
| W | GLN225 |
| W | ALA226 |
| W | ALA227 |
| W | GLN228 |
| X | HIS18 |
| X | GLY27 |
| X | ARG28 |
| X | TYR29 |
| X | ARG113 |
| X | CYS137 |
| X | ALA138 |
| X | LEU139 |
| X | LEU140 |
| X | LEU142 |
| X | LEU142 |
| X | ASP143 |
| X | ARG220 |
| X | ILE221 |
| X | ILE222 |
| X | GLY223 |
| X | GLU225 |
| X | ALA226 |
| X | ARG227 |
| X | VAL228 |
Functional Information from PROSITE/UniProt
| site_id | PS00167 |
| Number of Residues | 14 |
| Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IEVGvPYSDPGMDG |
| Chain | Residue | Details |
| A | ILE56-GLY69 |
| site_id | PS00168 |
| Number of Residues | 15 |
| Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LnHtGSHKiNnvLgQ |
| Chain | Residue | Details |
| B | LEU94-GLN108 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255|HAMAP-Rule:MF_00133 |
| Chain | Residue | Details |
| B | LYS101 | |
| T | LYS101 | |
| V | LYS101 | |
| X | LYS101 | |
| M | GLU57 | |
| M | ASP68 | |
| O | GLU57 | |
| O | ASP68 | |
| Q | GLU57 | |
| Q | ASP68 | |
| S | GLU57 | |
| D | LYS101 | |
| S | ASP68 | |
| U | GLU57 | |
| U | ASP68 | |
| W | GLU57 | |
| W | ASP68 | |
| F | LYS101 | |
| H | LYS101 | |
| J | LYS101 | |
| L | LYS101 | |
| N | LYS101 | |
| P | LYS101 | |
| R | LYS101 |
