1HQ5
CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH S-(2-BORONOETHYL)-L-CYSTEINE, AN L-ARGININE ANALOGUE
Summary for 1HQ5
Entry DOI | 10.2210/pdb1hq5/pdb |
Related | 1D3V 1RLA |
Descriptor | ARGINASE 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE, ... (4 entities in total) |
Functional Keywords | binuclear manganese cluster, boronic acid inhibitor, perfectly twinned crystal, hydrolase |
Biological source | Rattus norvegicus (Norway rat) |
Cellular location | Cytoplasm : P07824 |
Total number of polymer chains | 2 |
Total formula weight | 70678.02 |
Authors | Kim, N.N.,Cox, J.D.,Baggio, R.F.,Emig, F.A.,Mistry, S.K.,Harper, S.L.,Speicher, D.W.,Morris Jr., S.M.,Ash, D.E.,Traish, A.,Christianson, D.W. (deposition date: 2000-12-14, release date: 2001-04-04, Last modification date: 2024-02-07) |
Primary citation | Kim, N.N.,Cox, J.D.,Baggio, R.F.,Emig, F.A.,Mistry, S.K.,Harper, S.L.,Speicher, D.W.,Morris Jr., S.M.,Ash, D.E.,Traish, A.,Christianson, D.W. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry, 40:2678-2688, 2001 Cited by PubMed: 11258879DOI: 10.1021/bi002317h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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