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PDB: 106 件
4PGJ
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Human heavy-chain domain antibody in complex with hen egg-white lysozyme
分子名称: Human heavy chain domain antibody, Lysozyme C
著者Christ, D, Langley, D.B, Rouet, R.
登録日2014-05-02
公開日2015-03-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies.
J.Biol.Chem., 290, 2015
6BMB
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Crystal structure of Arabidopsis Dehydroquinate dehydratase-shikimate dehydrogenase (T381G mutant) in complex with tartrate and shikimate
分子名称: (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic, ...
著者Christendat, D, Peek, J.
登録日2017-11-14
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.077 Å)
主引用文献Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases.
Plant J., 2018
6BMQ
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Crystal structure of Arabidopsis Dehydroquinate dehydratase-shikimate dehydrogenase (T381G mutant) in complex with tartrate and shikimate
分子名称: (1S,3R,4S,5R)-1,3,4,5-tetrahydroxycyclohexanecarboxylic acid, Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic, ...
著者Christendat, D, Peek, J.
登録日2017-11-15
公開日2018-09-26
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.077 Å)
主引用文献Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases.
Plant J., 2018
3PWZ
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Crystal structure of an Ael1 enzyme from Pseudomonas putida
分子名称: Shikimate dehydrogenase 3
著者Christendat, D, Peek, J.
登録日2010-12-09
公開日2011-09-28
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.705 Å)
主引用文献Structural and mechanistic analysis of a novel class of shikimate dehydrogenases: evidence for a conserved catalytic mechanism in the shikimate dehydrogenase family.
Biochemistry, 50, 2011
2O7Q
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Crystal Structure of the A. thaliana DHQ-dehydroshikimate-SDH-shikimate-NADP(H)
分子名称: 3-DEHYDROSHIKIMATE, Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, SULFATE ION
著者Christendat, D, Singh, S.A.
登録日2006-12-11
公開日2007-11-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The DHQ-dehydroshikimate-SDH-shikimate-NADP(H) Complex: Insights into Metabolite Transfer in the Shikimate Pathway
Cryst.Growth Des., 7, 2007
2O7S
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Crystal Structure of the A. thaliana DHQ-dehydroshikimate-SDH-shikimate-NADP(H)
分子名称: 3-DEHYDROSHIKIMATE, Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, L(+)-TARTARIC ACID, ...
著者Christendat, D, Singh, S.A.
登録日2006-12-11
公開日2007-11-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献The DHQ-dehydroshikimate-SDH-shikimate-NADP(H) Complex: Insights into Metabolite Transfer in the Shikimate Pathway
Cryst.Growth Des., 7, 2007
1KJN
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Structure of MT0777
分子名称: MTH0777
著者Christendat, D, Edwards, A, Joachimiak, A, Korolev, S, Midwest Center for Structural Genomics (MCSG)
登録日2001-12-04
公開日2002-08-14
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of MT0777
To be published
1L1S
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Structure of Protein of Unknown Function MTH1491 from Methanobacterium thermoautotrophicum
分子名称: hypothetical protein MTH1491
著者Christendat, D, Saridakis, V, Kim, Y, Kumar, P.A, Xu, X, Semesi, A, Joachimiak, A, Arrowsmith, C.H, Edwards, A.M, Midwest Center for Structural Genomics (MCSG)
登録日2002-02-19
公開日2002-05-29
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum.
Protein Sci., 11, 2002
1EJE
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CRYSTAL STRUCTURE OF AN FMN-BINDING PROTEIN
分子名称: FLAVIN MONONUCLEOTIDE, FMN-BINDING PROTEIN, NICKEL (II) ION, ...
著者Christendat, D, Saridakis, V, Bochkarev, A, Arrowsmith, C, Edwards, A.M, Northeast Structural Genomics Consortium (NESG)
登録日2000-03-02
公開日2000-10-11
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural proteomics of an archaeon.
Nat.Struct.Biol., 7, 2000
1EP0
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HIGH RESOLUTION CRYSTAL STRUCTURE OF DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM
分子名称: DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE
著者Christendat, D, Saridakis, V, Bochkarev, A, Pai, E.F, Arrowsmith, C.H, Edwards, A.M, Northeast Structural Genomics Consortium (NESG)
登録日2000-03-24
公開日2000-12-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.
J.Biol.Chem., 275, 2000
1EPZ
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CRYSTAL STRUCTURE OF DTDP-6-DEOXY-D-XYLO-4-HEXULOASE 3,5-EPIMERASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM WITH BOUND LIGAND.
分子名称: DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE, THYMIDINE-5'-DIPHOSPHATE
著者Christendat, D, Saridakis, V, Bochkarev, A, Pai, E.F, Arrowsmith, C, Edwards, A.M.
登録日2000-03-30
公開日2000-12-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.
J.Biol.Chem., 275, 2000
1EIJ
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NMR ENSEMBLE OF METHANOBACTERIUM THERMOAUTOTROPHICUM PROTEIN 1615
分子名称: HYPOTHETICAL PROTEIN MTH1615
著者Christendat, D, Booth, V, Gernstein, M, Arrowsmith, C.H, Edwards, A.M, Northeast Structural Genomics Consortium (NESG)
登録日2000-02-25
公開日2000-11-03
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structural proteomics of an archaeon.
Nat.Struct.Biol., 7, 2000
7MSQ
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Complex between the Fab arm of AB-3467 and the SARS-CoV-2 receptor binding domain (RBD)
分子名称: AB-3467 Fab Heavy Chain, AB-3467 Fab Light Chain, CHLORIDE ION, ...
著者Langley, D.B, Christ, D.
登録日2021-05-12
公開日2022-01-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability.
Immunity, 54, 2021
5VJO
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Complex between HyHEL10 Fab fragment heavy chain mutant I29F and Pekin duck egg lysozyme isoform I (DEL-I)
分子名称: CHLORIDE ION, HyHEL10 heavy chain Fab fragment carrying I29F mutation., HyHEL10 light chain Fab fragment, ...
著者Langley, D.B, Christ, D.
登録日2017-04-19
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.
Science, 360, 2018
6D9I
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Pekin duck egg lysozyme isoform II (DEL-II)
分子名称: CHLORIDE ION, Lysozyme, MAGNESIUM ION
著者Langley, D.B, Christ, D.
登録日2018-04-30
公開日2018-09-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Crystal structure of duck egg lysozyme isoform II (DEL-II).
BMC Struct. Biol., 18, 2018
6MH2
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BU of 6mh2 by Molmil
Structure of Herceptin Fab without antigen
分子名称: Herceptin Fab arm heavy chain, Herceptin Fab arm light chain
著者Luthra, A, Langley, D.B, Christie, M, Christ, D.
登録日2018-09-17
公開日2019-05-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Human Antibody Bispecifics through Phage Display Selection.
Biochemistry, 58, 2019
4U3X
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Structure of a human VH antibody domain binding to the cleft of hen egg lysozyme
分子名称: 1,2-ETHANEDIOL, Human VH domain antibody, Lysozyme C
著者Rouet, R, Langley, D.B, Christ, D.
登録日2014-07-23
公開日2015-03-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies
J.Biol.Chem., 290, 2015
6BFT
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Structure of Bevacizumab Fab mutant in complex with VEGF
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Avastin Heavy Chain Fab fragment mutant, Avastin Light Chain Fab fragment mutant, ...
著者Christie, M, Christ, D.
登録日2017-10-27
公開日2018-10-31
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Stable human IgG antibody therapeutics with native framework structure
To Be Published
6BGT
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Structure of Trastuzumab Fab mutant in complex with Her2 extracellular domain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Herceptin heavy chain Fab fragment mutant, Herceptin light chain mutant, ...
著者Christie, M, Christ, D.
登録日2017-10-29
公開日2018-10-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Stable human IgG antibody therapeutics with native framework structure
To Be Published
5VJQ
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Complex between HyHEL10 Fab fragment heavy chain mutant (I29F, S52T, Y53F) and Pekin duck egg lysozyme isoform I (DEL-I)
分子名称: CHLORIDE ION, GLYCEROL, HyHEL10 heavy chain Fab fragment carrying three mutations; I29F, ...
著者Langley, D.B, Christ, D.
登録日2017-04-19
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.
Science, 360, 2018
3UPA
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BU of 3upa by Molmil
A general strategy for the generation of human antibody variable domains with increased aggregation resistance
分子名称: kappa light chain variable domain
著者Dudgeon, K, Rouet, R, Kokmeijer, I, Langley, D.B, Christ, D.
登録日2011-11-17
公開日2012-06-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献General strategy for the generation of human antibody variable domains with increased aggregation resistance
Proc.Natl.Acad.Sci.USA, 109, 2012
3UPC
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A general strategy for the generation of human antibody variable domains with increased aggregation resistance
分子名称: DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ...
著者Dudgeon, K, Rouet, R, Kokmeijer, I, Langley, D.B, Christ, D.
登録日2011-11-17
公開日2012-06-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献General strategy for the generation of human antibody variable domains with increased aggregation resistance
Proc.Natl.Acad.Sci.USA, 109, 2012
4UZM
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Shotgun proteolysis: A practical application
分子名称: PUTATIVE MEMBRANE PROTEIN IGAA HOMOLOG
著者Allen, M.D, Bycroft, M, Freund, S.M.V, Christ, D.
登録日2014-09-05
公開日2014-09-17
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution Structure of a Soluble Fragment Derived from a Membrane Protein by Shotgun Proteolysis.
Protein Eng.Des.Sel., 28, 2015
4X4X
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Retrofitting antibodies with stabilizing mutations. Herceptin scFv mutant.
分子名称: Human Variable Heavy Chain of Herceptin, Human Variable Light Chain of Herceptin
著者Langley, D.B, Roome, B, Christ, D.
登録日2014-12-04
公開日2015-12-23
最終更新日2020-01-08
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Retrofitting antibodies with stabilizing mutations
To Be Published
4X4Z
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Retrofitting antibodies with stabilizing mutations. Herceptin VL mutant F53D.
分子名称: Herceptin VL domain with F53D mutation
著者Langley, D.B, Rouet, R, Christ, D.
登録日2014-12-04
公開日2015-12-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Retrofitting antibodies with stabilizing mutations
To Be Published

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件を2024-08-21に公開中

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