3UPC

A general strategy for the generation of human antibody variable domains with increased aggregation resistance

Summary for 3UPC

Entry DOI	10.2210/pdb3upc/pdb
Related	3UPA
Descriptor	heavy chain variable domain, PENTAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... (5 entities in total)
Functional Keywords	immunoglobulin fold, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	10
Total formula weight	122428.96
Authors	Dudgeon, K.,Rouet, R.,Kokmeijer, I.,Langley, D.B.,Christ, D. (deposition date: 2011-11-17, release date: 2012-06-20, Last modification date: 2023-11-01)
Primary citation	Dudgeon, K.,Rouet, R.,Kokmeijer, I.,Schofield, P.,Stolp, J.,Langley, D.,Stock, D.,Christ, D. General strategy for the generation of human antibody variable domains with increased aggregation resistance Proc.Natl.Acad.Sci.USA, 109:10879-10884, 2012 Cited by PubMed: 22745168 DOI: 10.1073/pnas.1202866109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation