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3UPC

A general strategy for the generation of human antibody variable domains with increased aggregation resistance

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D, E...
(A, B, C, D, E...)
heavy chain variable domainpolymer11312111.310Pfam (PF07686)
UniProt (by SIFTS) (P01764)
Homo sapiens (human)
2K, N
(A, D)
PENTAETHYLENE GLYCOLnon-polymer238.32Chemie (1PE)
3L
(B)
TRIETHYLENE GLYCOLnon-polymer150.21Chemie (PGE)
4M
(C)
DI(HYDROXYETHYL)ETHERnon-polymer106.11Chemie (PEG)
5O, P, Q
(G, H, I)
TETRAETHYLENE GLYCOLnon-polymer194.23Chemie (PG4)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains10
Total formula weight121113.4
Non-Polymers*Number of molecules7
Total formula weight1315.5
All*Total formula weight122429.0
*Water molecules are not included.

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PDB entries from 2025-06-18

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