3UPC

A general strategy for the generation of human antibody variable domains with increased aggregation resistance

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003823	molecular_function	antigen binding
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0006955	biological_process	immune response
A	0016064	biological_process	immunoglobulin mediated immune response
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle
B	0003823	molecular_function	antigen binding
B	0005576	cellular_component	extracellular region
B	0005886	cellular_component	plasma membrane
B	0006955	biological_process	immune response
B	0016064	biological_process	immunoglobulin mediated immune response
B	0070062	cellular_component	extracellular exosome
B	0072562	cellular_component	blood microparticle
C	0003823	molecular_function	antigen binding
C	0005576	cellular_component	extracellular region
C	0005886	cellular_component	plasma membrane
C	0006955	biological_process	immune response
C	0016064	biological_process	immunoglobulin mediated immune response
C	0070062	cellular_component	extracellular exosome
C	0072562	cellular_component	blood microparticle
D	0003823	molecular_function	antigen binding
D	0005576	cellular_component	extracellular region
D	0005886	cellular_component	plasma membrane
D	0006955	biological_process	immune response
D	0016064	biological_process	immunoglobulin mediated immune response
D	0070062	cellular_component	extracellular exosome
D	0072562	cellular_component	blood microparticle
E	0003823	molecular_function	antigen binding
E	0005576	cellular_component	extracellular region
E	0005886	cellular_component	plasma membrane
E	0006955	biological_process	immune response
E	0016064	biological_process	immunoglobulin mediated immune response
E	0070062	cellular_component	extracellular exosome
E	0072562	cellular_component	blood microparticle
F	0003823	molecular_function	antigen binding
F	0005576	cellular_component	extracellular region
F	0005886	cellular_component	plasma membrane
F	0006955	biological_process	immune response
F	0016064	biological_process	immunoglobulin mediated immune response
F	0070062	cellular_component	extracellular exosome
F	0072562	cellular_component	blood microparticle
G	0003823	molecular_function	antigen binding
G	0005576	cellular_component	extracellular region
G	0005886	cellular_component	plasma membrane
G	0006955	biological_process	immune response
G	0016064	biological_process	immunoglobulin mediated immune response
G	0070062	cellular_component	extracellular exosome
G	0072562	cellular_component	blood microparticle
H	0003823	molecular_function	antigen binding
H	0005576	cellular_component	extracellular region
H	0005886	cellular_component	plasma membrane
H	0006955	biological_process	immune response
H	0016064	biological_process	immunoglobulin mediated immune response
H	0070062	cellular_component	extracellular exosome
H	0072562	cellular_component	blood microparticle
I	0003823	molecular_function	antigen binding
I	0005576	cellular_component	extracellular region
I	0005886	cellular_component	plasma membrane
I	0006955	biological_process	immune response
I	0016064	biological_process	immunoglobulin mediated immune response
I	0070062	cellular_component	extracellular exosome
I	0072562	cellular_component	blood microparticle
J	0003823	molecular_function	antigen binding
J	0005576	cellular_component	extracellular region
J	0005886	cellular_component	plasma membrane
J	0006955	biological_process	immune response
J	0016064	biological_process	immunoglobulin mediated immune response
J	0070062	cellular_component	extracellular exosome
J	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE A 2

Chain	Residue
A	SER35
A	VAL37
A	TRP47
A	TRP106

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE D 116

Chain	Residue
C	PEG116
D	TYR100
D	TRP106

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 H 1

Chain	Residue
H	TYR100
H	TRP106
G	PG4116
H	TRP47

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PG4 G 116

Chain	Residue
G	TYR105
G	TRP106
H	PG41

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 I 116

Chain	Residue
I	TRP47
I	TYR100
I	TYR105
I	TRP106

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE B 116

Chain	Residue
B	TRP47
B	TYR100
B	TRP106
C	PEG116

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG C 116

Chain	Residue
B	PGE116
C	TRP47
C	TYR100
C	TRP106
D	1PE116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Region: {"description":"Complementarity-determining-1","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	160
Details	Region: {"description":"Framework-2","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	70
Details	Region: {"description":"Complementarity-determining-2","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	370
Details	Region: {"description":"Framework-3","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Region: {"description":"Complementarity-determining-3","evidences":[{"source":"UniProtKB","id":"P23083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---