5FR2
 
 | | Farnesylated RhoA-GDP in complex with RhoGDI-alpha, lysine acetylated at K178 | | Descriptor: | FARNESYL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Kuhlmann, N, Wroblowski, S, Knyphausen, P, de Boor, S, Brenig, J, Zienert, A.Y, Meyer-Teschendorf, K, Praefcke, G.J.K, Nolte, H, Krueger, M, Schacherl, M, Baumann, U, James, L.C, Chin, J.W, Lammers, M. | | Deposit date: | 2015-12-15 | | Release date: | 2016-01-13 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Structural and Mechanistic Insights Into the Regulation of the Fundamental Rho-Regulator Rhogdi Alpha by Lysine Acetylation.
J.Biol.Chem., 291, 2016
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6KNR
 | | Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699 | | Descriptor: | (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol, Estrogen-related receptor gamma | | Authors: | Yoon, H, Kim, J, Chin, J, Song, J, Cho, S.J. | | Deposit date: | 2019-08-07 | | Release date: | 2020-08-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.804 Å) | | Cite: | An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Eur.J.Med.Chem., 205, 2020
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6A6K
 | | Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 | | Descriptor: | 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol, Estrogen-related receptor gamma | | Authors: | Yoon, H, Kim, J, Chin, J, Cho, S.J, Song, J. | | Deposit date: | 2018-06-28 | | Release date: | 2019-04-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.
J. Med. Chem., 62, 2019
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5Y7X
 | | Human Peroxisome proliferator-activated receptor (PPAR) delta in complexed with a potent and selective agonist | | Descriptor: | 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-selenazol-5-yl]methylsulfanyl]phenoxy]ethanoic acid, CHLORIDE ION, POTASSIUM ION, ... | | Authors: | Kim, H.L, Chin, J.W, Cho, S.J, Song, J.Y, Yoon, H.S, Bae, J.H. | | Deposit date: | 2017-08-18 | | Release date: | 2018-08-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.699 Å) | | Cite: | Design, synthesis, and the X-ray co-crystal structure of Highly Potent, Selective, and Orally Bioavailable, Novel Peroxisome Proliferator-Activated Receptor delta Agonists
To Be Published
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6ILQ
 | | Crystal structure of PPARgamma with compound BR101549 | | Descriptor: | Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma, ethyl [2-butyl-6-oxo-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl}-4-(propan-2-yl)-1,6-dihydropyrimidin-5-yl]acetate | | Authors: | Hong, E, Jang, T.H, Chin, J, Kim, K.H, Jung, W, Kim, S.H. | | Deposit date: | 2018-10-19 | | Release date: | 2019-09-11 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.408 Å) | | Cite: | Identification of BR101549 as a lead candidate of non-TZD PPAR gamma agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR.
Bioorg.Med.Chem.Lett., 29, 2019
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6ICJ
 | | Crystal structure of PPARgamma with compound BR102375K | | Descriptor: | 2-butyl-5-[(3-tert-butyl-1,2,4-oxadiazol-5-yl)methyl]-6-methyl-3-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl}pyrimidin-4(3H)-one, GLYCEROL, Nuclear receptor coactivator 1, ... | | Authors: | Hong, E, Chin, J, Jang, T.H, Kim, K.H, Jung, W, Kim, S.H. | | Deposit date: | 2018-09-06 | | Release date: | 2019-09-11 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.483 Å) | | Cite: | Crystal structure of PPARgamma with compound BR102375K
To Be Published
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6HRM
 | | E. coli 70S d2d8 stapled ribosome | | Descriptor: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | Authors: | Schmied, W.H, Tnimov, Z, Uttamapinant, C, Rae, C.D, Fried, S.D, Chin, J.W. | | Deposit date: | 2018-09-27 | | Release date: | 2018-12-19 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Controlling orthogonal ribosome subunit interactions enables evolution of new function.
Nature, 564, 2018
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6ZGA
 | | COPII on membranes, inner coat | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PRO-PRO-PRO, ... | | Authors: | Zanetti, G, Hutchings, J, Cheung, A.C.M. | | Deposit date: | 2020-06-18 | | Release date: | 2021-02-17 | | Last modified: | 2021-04-14 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network.
Nat Commun, 12, 2021
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6ZG6
 | | COPII on membranes, outer coat vertex | | Descriptor: | Protein transport protein SEC13, Protein transport protein SEC31 | | Authors: | Zanetti, G, Hutchings, J. | | Deposit date: | 2020-06-18 | | Release date: | 2021-02-17 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (12 Å) | | Cite: | Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network.
Nat Commun, 12, 2021
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3ZKX
 | | TERNARY BACE2 XAPERONE COMPLEX | | Descriptor: | BETA-SECRETASE 2, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Kuglstatter, A, Banner, D.W, Benz, J, Bertschinger, J, Burger, D, Cuppuleri, S, Debulpaep, M, Gast, A, Grabulovski, D, Gsell, B, Hilpert, H, Huber, W, Kusznir, E, Laeremans, T, Matile, H, Rufer, A, Schlatter, D, Steyeart, J, Stihle, M, Thoma, R, Weber, M, Ruf, A. | | Deposit date: | 2013-01-25 | | Release date: | 2013-05-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones
Acta Crystallogr.,Sect.D, 69, 2013
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8DJH
 | | Ternary complex of SUMO1 with a phosphomimetic SIM of PML and zinc | | Descriptor: | PML 4SD, Small ubiquitin-related modifier 1, ZINC ION | | Authors: | Lussier-Price, M, Wahba, H.M, Mascle, X.H, Cappadocia, L, Bourdeau, V, Gagnon, C, Igelmann, S, Sakaguchi, K, Ferbeyre, G, Omichinski, J.G. | | Deposit date: | 2022-06-30 | | Release date: | 2022-08-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1.
Nucleic Acids Res., 50, 2022
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8DJI
 | | Ternary complex of SUMO1 with the SIM of PML and zinc | | Descriptor: | Protein PML, Small ubiquitin-related modifier 1, ZINC ION | | Authors: | Lussier-Price, M, Wahba, H.M, Mascle, X.H, Cappadocia, L, Bourdeau, V, Gagnon, C, Igelmann, S, Sakaguchi, K, Ferbeyre, G, Omichinski, J.G. | | Deposit date: | 2022-06-30 | | Release date: | 2022-08-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1.
Nucleic Acids Res., 50, 2022
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6ZG5
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6ZL0
 | | COPII on membranes, outer coat left-handed rod | | Descriptor: | Protein transport protein SEC13, Protein transport protein SEC31 | | Authors: | Zanetti, G, Hutchings, J. | | Deposit date: | 2020-06-30 | | Release date: | 2021-02-17 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (40 Å) | | Cite: | Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network.
Nat Commun, 12, 2021
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3ZNF
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4WJQ
 | | Crystal Structure of SUMO1 in complex with Daxx | | Descriptor: | Daxx, Small ubiquitin-related modifier 1 | | Authors: | Cappadocia, L, Mascle, X.H, Bourdeau, V, Tremblay-Belzile, S, Chaker-Margot, M, Lussier-Price, M, Wada, J, Sakaguchi, K, Aubry, M, Ferbeyre, G, Omichinski, J.G. | | Deposit date: | 2014-10-01 | | Release date: | 2014-12-31 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1.
Structure, 23, 2015
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4WJN
 | | Crystal structure of SUMO1 in complex with phosphorylated PML | | Descriptor: | Protein PML, Small ubiquitin-related modifier 1 | | Authors: | Cappadocia, L, Mascle, X.H, Bourdeau, V, Tremblay-Belzile, S, Chaker-Margot, M, Lussier-Price, M, Wada, J, Sakaguchi, K, Aubry, M, Ferbeyre, G, Omichinski, J.G. | | Deposit date: | 2014-10-01 | | Release date: | 2014-12-31 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1.
Structure, 23, 2015
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4WJP
 | | Crystal Structure of SUMO1 in complex with phosphorylated Daxx | | Descriptor: | Daxx, Small ubiquitin-related modifier 1 | | Authors: | Cappadocia, L, Mascle, X.H, Bourdeau, V, Tremblay-Belzile, S, Chaker-Margot, M, Lussier-Price, M, Wada, J, Sakaguchi, K, Aubry, M, Ferbeyre, G, Omichinski, J.G. | | Deposit date: | 2014-10-01 | | Release date: | 2014-12-31 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1.
Structure, 23, 2015
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4WJO
 | | Crystal Structure of SUMO1 in complex with PML | | Descriptor: | Protein PML, Small ubiquitin-related modifier 1 | | Authors: | Cappadocia, L, Mascle, X.H, Bourdeau, V, Tremblay-Belzile, S, Chaker-Margot, M, Lussier-Price, M, Wada, J, Sakaguchi, K, Aubry, M, Ferbeyre, G, Omichinski, J.G. | | Deposit date: | 2014-10-01 | | Release date: | 2014-12-31 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1.
Structure, 23, 2015
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5SXP
 | | STRUCTURAL BASIS FOR THE INTERACTION BETWEEN ITCH PRR AND BETA-PIX | | Descriptor: | E3 ubiquitin-protein ligase Itchy homolog, Rho guanine nucleotide exchange factor 7 | | Authors: | Cappadocia, L, Desrochers, G, Lussier-Price, M, Angers, A, Omichinski, J.G. | | Deposit date: | 2016-08-09 | | Release date: | 2017-03-01 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
J. Biol. Chem., 292, 2017
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7NRT
 | | Conformation 2 of straight filament from primary age-related tauopathy brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2021-03-04 | | Release date: | 2021-03-24 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Acta Neuropathol, 141, 2021
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7NRX
 | | Straight filament from Alzheimer's disease with PET ligand APN-1607 | | Descriptor: | Microtubule-associated protein tau | | Authors: | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2021-03-04 | | Release date: | 2021-03-24 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Acta Neuropathol, 141, 2021
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7NRV
 | | Paired helical filament from Alzheimer's disease with PET ligand APN-1607 | | Descriptor: | Microtubule-associated protein tau | | Authors: | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2021-03-04 | | Release date: | 2021-03-24 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Acta Neuropathol, 141, 2021
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7NRS
 | | Conformation 1 of straight filament from primary age-related tauopathy brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2021-03-04 | | Release date: | 2021-03-24 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Acta Neuropathol, 141, 2021
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7NRQ
 | | Paired helical filament from primary age-related tauopathy brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2021-03-04 | | Release date: | 2021-03-24 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Acta Neuropathol, 141, 2021
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