5SXP

STRUCTURAL BASIS FOR THE INTERACTION BETWEEN ITCH PRR AND BETA-PIX

Summary for 5SXP

Entry DOI	10.2210/pdb5sxp/pdb
Descriptor	Rho guanine nucleotide exchange factor 7, E3 ubiquitin-protein ligase Itchy homolog (3 entities in total)
Functional Keywords	sh3 domain peptide ligand complex, ligase, signaling protein-ligase complex, signaling protein/ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	34011.34
Authors	Cappadocia, L.,Desrochers, G.,Lussier-Price, M.,Angers, A.,Omichinski, J.G. (deposition date: 2016-08-09, release date: 2017-03-01, Last modification date: 2023-10-04)
Primary citation	Desrochers, G.,Cappadocia, L.,Lussier-Price, M.,Ton, A.T.,Ayoubi, R.,Serohijos, A.,Omichinski, J.G.,Angers, A. Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch. J. Biol. Chem., 292:6325-6338, 2017 Cited by PubMed: 28235806 DOI: 10.1074/jbc.M116.754440 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation