8PVE
| Structure of AHIR determined by cryoEM at 100 keV | Descriptor: | Ketol-acid reductoisomerase (NADP(+)) | Authors: | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | Deposit date: | 2023-07-17 | Release date: | 2023-11-29 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8PVJ
| Structure of lumazine synthase determined by cryoEM at 100 keV | Descriptor: | 6,7-dimethyl-8-ribityllumazine synthase | Authors: | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | Deposit date: | 2023-07-17 | Release date: | 2023-11-29 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8PV9
| Structure of DPS determined by cryoEM at 100 keV | Descriptor: | DNA protection during starvation protein | Authors: | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | Deposit date: | 2023-07-17 | Release date: | 2023-11-29 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8PVD
| Structure of catalase determined by cryoEM at 100 keV | Descriptor: | Catalase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE | Authors: | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | Deposit date: | 2023-07-17 | Release date: | 2023-11-29 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8PVH
| Structure of human apo ALDH1A1 determined by cryoEM at 100 keV | Descriptor: | Aldehyde dehydrogenase 1A1, CHLORIDE ION | Authors: | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | Deposit date: | 2023-07-17 | Release date: | 2023-11-29 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
7C94
| Crystal structure of the anti-human podoplanin antibody Fab fragment complex with glycopeptide | Descriptor: | GLYCEROL, Heavy chain of Fab fragment, Light chain of Fab fragment, ... | Authors: | Suzuki, K, Nakamura, S, Ogasawara, S, Naruchi, K, Shimabukuro, J, Tukahara, N, Kaneko, M.K, Kato, Y, Murata, T. | Deposit date: | 2020-06-04 | Release date: | 2020-09-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Crystal structure of an anti-podoplanin antibody bound to a disialylated O-linked glycopeptide. Biochem.Biophys.Res.Commun., 533, 2020
|
|
6KXX
| Human PPAR alpha ligand binding domain in complex with a synthetic agonist (compound A) | Descriptor: | 1-(4-chlorophenyl)-6-methyl-3-propan-2-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid, PGC1alpha, Peroxisome proliferator-activated receptor alpha | Authors: | Yoshida, T, Tachibana, K, Oki, H, Doi, M, Fukuda, S, Yuzuriha, T, Tabata, R, Ishimoto, K, Kawahara, K, Ohkubo, T, Miyachi, H, Doi, T. | Deposit date: | 2019-09-14 | Release date: | 2020-05-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Basis for PPAR alpha Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives. Sci Rep, 10, 2020
|
|
6KXY
| Human PPAR alpha ligand binding domain in complex with a synthetic agonist (compound B) | Descriptor: | 6-ethyl-1-(4-fluorophenyl)-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid, PGC1alpha, Peroxisome proliferator-activated receptor alpha | Authors: | Yoshida, T, Tachibana, K, Oki, H, Doi, M, Fukuda, S, Yuzuriha, T, Tabata, R, Ishimoto, K, Kawahara, K, Ohkubo, T, Miyachi, H, Doi, T. | Deposit date: | 2019-09-14 | Release date: | 2020-05-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for PPAR alpha Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives. Sci Rep, 10, 2020
|
|
5KB5
| Crystal structure of the adenosine kinase from Mus musculus in complex with adenosine and adenosine-diphosphate | Descriptor: | ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, Adenosine kinase, ... | Authors: | Oliveira, R.R, Neto, R.M, Polo, C.C, Tonoli, C.C.C, Murakami, M.T, Franchini, K.G. | Deposit date: | 2016-06-02 | Release date: | 2017-06-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the adenosine kinase from Mus musculus in complex with adenosine and adenosine-diphosphate To Be Published
|
|
8PVA
| Structure of bacterial ribosome determined by cryoEM at 100 keV | Descriptor: | 16S rRNA, 23S rRNA, 50S ribosomal protein L14, ... | Authors: | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | Deposit date: | 2023-07-17 | Release date: | 2023-11-29 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8PVG
| Structure of E. coli glutamine synthetase determined by cryoEM at 100 keV | Descriptor: | Glutamine synthetase | Authors: | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | Deposit date: | 2023-07-17 | Release date: | 2023-11-29 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8PVB
| Structure of GABAAR determined by cryoEM at 100 keV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ... | Authors: | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | Deposit date: | 2023-07-17 | Release date: | 2023-11-29 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8PVI
| Structure of PaaZ determined by cryoEM at 100 keV | Descriptor: | Bifunctional protein PaaZ | Authors: | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | Deposit date: | 2023-07-17 | Release date: | 2023-11-29 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8PVF
| Structure of GAPDH determined by cryoEM at 100 keV | Descriptor: | Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | Deposit date: | 2023-07-17 | Release date: | 2023-11-29 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
7S0P
| Crystal structure of Porcine Factor VIII C2 Domain Bound to Phosphatidylserine | Descriptor: | Coagulation factor VIII, PHOSPHOSERINE | Authors: | Peters, S.C, Childers, K.C, Wo, S.W, Brison, C.M, Swanson, C.D, Spiegel, P.C. | Deposit date: | 2021-08-30 | Release date: | 2021-10-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII. Front Mol Biosci, 9, 2022
|
|
7D5B
| BACE2 xaperone complex with N-{3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-5,6-dihydro-2H-1lambda6,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide | Descriptor: | 1,2-ETHANEDIOL, Beta-secretase 2, CHLORIDE ION, ... | Authors: | Fujimoto, K, Yoshida, S, Tadano, G, Asada, N, Fuchino, K, Suzuki, S, Matsuoka, E, Yamamoto, T, Yamamoto, S, Ando, S, Kanegawa, N, Tonomura, Y, Ito, H, Moechars, D, Rombouts, F.J.R, Gijsen, H.J.M, Kusakabe, K.I. | Deposit date: | 2020-09-25 | Release date: | 2021-03-31 | Last modified: | 2021-04-07 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective beta-Secretase (BACE1) Inhibitors over BACE2. J.Med.Chem., 64, 2021
|
|
1L1V
| UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE | Descriptor: | 5'-D(*GP*TP*CP*AP*CP*CP*GP*AP*C)-3', ACTINOMYCIN D | Authors: | Chou, S.-H, Chin, K.-H, Chen, F.-M. | Deposit date: | 2002-02-20 | Release date: | 2002-03-06 | Last modified: | 2024-07-10 | Method: | SOLUTION NMR | Cite: | Looped Out and Perpendicular: Deformation of Watson-Crick Base Pair Associated with Actinomycin D Binding. Proc.Natl.Acad.Sci.USA, 99, 2002
|
|
5JR0
| |
6M9C
| PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR Pseudotyrostatin | Descriptor: | ACETIC ACID, CALCIUM ION, Pseudotyrostatin, ... | Authors: | Wlodawer, A, Li, M, Gustchina, A, Dauter, Z, Uchida, K, Oyama, H, Goldfarb, N.E, Dunn, B.M, Oda, K. | Deposit date: | 2018-08-23 | Release date: | 2018-10-24 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase Biochemistry, 40, 2001
|
|
1DPF
| CRYSTAL STRUCTURE OF A MG-FREE FORM OF RHOA COMPLEXED WITH GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, RHOA | Authors: | Shimizu, T, Ihara, K, Maesaki, R, Kuroda, S, Kaibuchi, K, Hakoshima, T. | Deposit date: | 1999-12-27 | Release date: | 2000-06-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism. J.Biol.Chem., 275, 2000
|
|
7VPY
| Crystal structure of the neutralizing nanobody P86 against SARS-CoV-2 | Descriptor: | 1,2-ETHANEDIOL, Nanobody, SULFATE ION | Authors: | Maeda, R, Fujita, J, Konishi, Y, Kazuma, Y, Yamazaki, H, Anzai, I, Yamaguchi, K, Kasai, K, Nagata, K, Yamaoka, Y, Miyakawa, K, Ryo, A, Shirakawa, K, Makino, F, Matsuura, Y, Inoue, T, Imura, A, Namba, K, Takaori-Kondo, A. | Deposit date: | 2021-10-18 | Release date: | 2022-07-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron. Commun Biol, 5, 2022
|
|
7VQ0
| Cryo-EM structure of the SARS-CoV-2 spike protein (2-up RBD) bound to neutralizing nanobodies P86 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Maeda, R, Fujita, J, Konishi, Y, Kazuma, Y, Yamazaki, H, Anzai, I, Yamaguchi, K, Kasai, K, Nagata, K, Yamaoka, Y, Miyakawa, K, Ryo, A, Shirakawa, K, Makino, F, Matsuura, Y, Inoue, T, Imura, A, Namba, K, Takaori-Kondo, A. | Deposit date: | 2021-10-18 | Release date: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron. Commun Biol, 5, 2022
|
|
8EL5
| Light harvesting phycobiliprotein HaPE555 from the cryptophyte Hemiselmis andersenii CCMP644 in an alternating tight to loose interface filament | Descriptor: | DiCys-(15,16)-Dihydrobiliverdin, GLYCEROL, PHYCOERYTHROBILIN, ... | Authors: | Rathbone, H.W, Michie, K.A, Laos, A.L, Curmi, P.M.G. | Deposit date: | 2022-09-23 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Molecular dissection of the soluble photosynthetic antenna from the cryptophyte alga Hemiselmis andersenii. Commun Biol, 6, 2023
|
|
8EL3
| Light harvesting phycobiliprotein HaPE555 from the cryptophyte Hemiselmis andersenii CCMP644 in a loose interface filament | Descriptor: | DiCys-(15,16)-Dihydrobiliverdin, PHYCOERYTHROBILIN, Phycoerythrin alpha-1 subunit, ... | Authors: | Rathbone, H.W, Michie, K.A, Laos, A.L, Curmi, P.M.G. | Deposit date: | 2022-09-23 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Molecular dissection of the soluble photosynthetic antenna from the cryptophyte alga Hemiselmis andersenii. Commun Biol, 6, 2023
|
|
3ATZ
| Crystal structure of TcOYE with pHBA | Descriptor: | FLAVIN MONONUCLEOTIDE, P-HYDROXYBENZALDEHYDE, Prostaglandin F2a synthase | Authors: | Okamoto, N, Yamaguchi, K, Mizohata, E, Tokuoka, K, Uchiyama, N, Sugiyama, S, Matsumura, H, Inaka, K, Urade, Y, Inoue, T. | Deposit date: | 2011-01-26 | Release date: | 2012-02-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structural insight into the stereoselective production of PGF2(alpha) by Old Yellow Enzyme from Trypanosoma cruzi J.Biochem., 150, 2011
|
|