6KXY

Human PPAR alpha ligand binding domain in complex with a synthetic agonist (compound B)

Summary for 6KXY

Entry DOI	10.2210/pdb6kxy/pdb
Descriptor	Peroxisome proliferator-activated receptor alpha, PGC1alpha, 6-ethyl-1-(4-fluorophenyl)-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid, ... (4 entities in total)
Functional Keywords	agonist, complex, nuclear receptor, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	33446.00
Authors	Yoshida, T.,Tachibana, K.,Oki, H.,Doi, M.,Fukuda, S.,Yuzuriha, T.,Tabata, R.,Ishimoto, K.,Kawahara, K.,Ohkubo, T.,Miyachi, H.,Doi, T. (deposition date: 2019-09-14, release date: 2020-05-20, Last modification date: 2023-11-22)
Primary citation	Yoshida, T.,Oki, H.,Doi, M.,Fukuda, S.,Yuzuriha, T.,Tabata, R.,Ishimoto, K.,Kawahara, K.,Ohkubo, T.,Miyachi, H.,Doi, T.,Tachibana, K. Structural Basis for PPAR alpha Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives. Sci Rep, 10:7623-7623, 2020 Cited by PubMed: 32376995 DOI: 10.1038/s41598-020-64527-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation