6KXY

Human PPAR alpha ligand binding domain in complex with a synthetic agonist (compound B)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue T06 A 501

Chain	Residue
A	ILE272
A	MET355
A	HIS440
A	VAL444
A	LEU456
A	TYR464
A	PHE273
A	CYS276
A	GLN277
A	SER280
A	TYR314
A	LEU344
A	LEU347
A	ILE354

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	129
Details	Region: {"description":"Required for heterodimerization with RXRA"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19116277","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ET1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Essential for heterodimerization with RXRA"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"LXXLL motif","evidences":[{"source":"UniProtKB","id":"O70343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O70343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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