7VQ0

Cryo-EM structure of the SARS-CoV-2 spike protein (2-up RBD) bound to neutralizing nanobodies P86

Summary for 7VQ0

• Entry DOI: 10.2210/pdb7vq0/pdb
• Related: 7VPY
• EMDB information: 32078
• Descriptor: Spike glycoprotein, Neutralizing nanobody P86, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: spike, nanobody, vhh, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 6
• Total formula weight: 473845.69

Authors

Maeda, R.,Fujita, J.,Konishi, Y.,Kazuma, Y.,Yamazaki, H.,Anzai, I.,Yamaguchi, K.,Kasai, K.,Nagata, K.,Yamaoka, Y.,Miyakawa, K.,Ryo, A.,Shirakawa, K.,Makino, F.,Matsuura, Y.,Inoue, T.,Imura, A.,Namba, K.,Takaori-Kondo, A. (deposition date: 2021-10-18, release date: 2022-07-20)

• Primary citation: Maeda, R.,Fujita, J.,Konishi, Y.,Kazuma, Y.,Yamazaki, H.,Anzai, I.,Watanabe, T.,Yamaguchi, K.,Kasai, K.,Nagata, K.,Yamaoka, Y.,Miyakawa, K.,Ryo, A.,Shirakawa, K.,Sato, K.,Makino, F.,Matsuura, Y.,Inoue, T.,Imura, A.,Namba, K.,Takaori-Kondo, A.; A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron.; Commun Biol, 5:669-669, 2022; PubMed: 35794202; DOI: 10.1038/s42003-022-03630-3

Experimental method

ELECTRON MICROSCOPY (3.03 Å)