1L1V
UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE
Summary for 1L1V
| Entry DOI | 10.2210/pdb1l1v/pdb |
| Related | 173D 1A7Y 1A7Z 1DSC 1DSD 1FJA 1I3W 1MNV 1OVF 1QFI 1UNJ 1UNM 209D 2D55 316D |
| Related PRD ID | PRD_000001 |
| Descriptor | 5'-D(*GP*TP*CP*AP*CP*CP*GP*AP*C)-3', ACTINOMYCIN D (2 entities in total) |
| Functional Keywords | actinomycin d, actinomycin, antibiotic, chromophore, anti cancer, antitumor, depsipeptide, mismatch, dna-antibiotic complex, dna/antibiotic |
| Biological source | STREPTOMYCES ANTIBIOTICUS |
| Total number of polymer chains | 2 |
| Total formula weight | 3992.23 |
| Authors | Chou, S.-H.,Chin, K.-H.,Chen, F.-M. (deposition date: 2002-02-20, release date: 2002-03-06, Last modification date: 2024-11-13) |
| Primary citation | Chou, S.H.,Chin, K.H.,Chen, F.M. Looped Out and Perpendicular: Deformation of Watson-Crick Base Pair Associated with Actinomycin D Binding. Proc.Natl.Acad.Sci.USA, 99:6625-, 2002 Cited by PubMed Abstract: Many anticancer drugs interact directly with DNA to exert their biological functions. To date, all noncovalent, intercalating drugs interact with DNA exclusively by inserting their chromophores into base steps to form elongated and unwound duplex structures without disrupting the flanking base pairs. By using actinomycin D (ActD)-5'-GXC/CYG-5' complexes as examples, we have found a rather unusual interaction mode for the intercalated drug; the central Watson-Crick X/Y base pairs are looped out and displaced by the ActD chromophore. The looped-out bases are not disordered but interact perpendicularly with the base/chromophore and form specific H bonds with DNA. Such a complex structure provides intriguing insights into how ligand interacts with DNA and enlarges the repertoires for sequence-specific DNA recognition. PubMed: 12011426DOI: 10.1073/PNAS.102580399 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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