173D

MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA

Summary for 173D

Related1A7Z 209D 1UNM 1I3W 1A7Y 1FJA 2D55 1DSC 1L1V 316D 1DSD 1MNV 1UNJ 1OVF 1QFI 172D
Related PRD IDPRD_000001
DescriptorDNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3'), ACTINOMYCIN D (3 entities in total)
Functional Keywordsactinomycin, antibiotic, antitumor, anticancer, chromophore, depsipeptide, dna-antibiotic complex, dna/antibiotic
Biological sourceSTREPTOMYCES ANTIBIOTICUS
Total number of polymer chains4
Total molecular weight7372.13
Authors
Kamitori, S.,Takusagawa, F. (deposition date: 1994-04-18, release date: 1994-10-15, Last modification date: 2017-11-01)
Primary citation
Kamitori, S.,Takusagawa, F.
Multiple Binding Modes of Anticancer Drug Actinomycin D: X-Ray, Molecular Modeling, and Spectroscopic Studies of D(Gaagcttc)2-Actinomycin D Complexes and its Host DNA
J.Am.Chem.Soc., 116:4154-, 1994
DOI: 10.1021/JA00089A002
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers38025.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 173d
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Molmil generated image of 173d
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Molmil generated image of 173d
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (173d.pdb2.gz [7.81 KB])
Coordinate files for Biological unit (173d.pdb1.gz [8.45 KB])