2D55

Structural, physical and biological characteristics of RNA.DNA binding agent N8-actinomycin D

Replaces:  1D55

Summary for 2D55

• Entry DOI: 10.2210/pdb2d55/pdb
• Related: 173D 1A7Y 1A7Z 1DSC 1DSD 1FJA 1I3W 1L1V 1MNV 1OVF 1QFI 1UNJ 1UNM 209D 316D
• Related PRD ID: PRD_000001
• Descriptor: DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3'), ACTINOMYCIN D (3 entities in total)
• Functional Keywords: actinomycin d, dactinomycin, antibiotic, anti cancer, antitumor, chromophore, depsipeptide, dna-antibiotic complex, dna/antibiotic
• Biological source: STREPTOMYCES ANTIBIOTICUS
• Total number of polymer chains: 3
• Total formula weight: 6112.68

Authors

Shinomiya, M.,Chu, W.,Carlson, R.G.,Weaver, R.F.,Takusagawa, F. (deposition date: 1995-05-01, release date: 1995-10-15, Last modification date: 2023-11-15)

• Primary citation: Kamitori, S.,Takusagawa, F.; Crystal Structure of the 2:1 Complex between D(Gaagcttc) and the Anticancer Drug Actinomycin D.; J.Mol.Biol., 225:445-, 1992; PubMed: 1593629; DOI: 10.1016/0022-2836(92)90931-9

Experimental method

X-RAY DIFFRACTION (3 Å)