1A7Y

CRYSTAL STRUCTURE OF ACTINOMYCIN D

Summary for 1A7Y

Entry DOI	10.2210/pdb1a7y/pdb
Related	173D 1A7Z 1DSC 1DSD 1FJA 1I3W 1L1V 1MNV 1OVF 1QFI 1UNJ 1UNM 209D 2D55 316D
Related PRD ID	PRD_000001
Descriptor	ACTINOMYCIN D, ETHYL ACETATE, METHANOL (3 entities in total)
Functional Keywords	actinomycin, antibiotic, antitumor, anticancer, chromophore, depsipeptide
Biological source	STREPTOMYCES ANTIBIOTICUS
Total number of polymer chains	3
Total formula weight	4523.11
Authors	Schafer, M.,Sheldrick, G.M.,Bahner, I.,Lackner, H. (deposition date: 1998-03-19, release date: 1999-03-23, Last modification date: 2024-11-20)
Primary citation	Schafer, M.,Sheldrick, G.M.,Bahner, I.,Lackner, H. Crystal Structures of Actinomycin D and Actinomycin Z3. Angew.Chem.Int.Ed.Engl., 37:2381-2384, 1998 Cited by PubMed Abstract: Untwinned single crystals of the actinomycins D and Z that diffracted to atomic resolution could be obtained for the first time. Low-temperature data collection and a new ab initio method for solving the structures led to precise crystal structures which showed, for example, that the unit cell of actinomycin D contains three molecules, two of which are present in the form of a hydrogen-bridged dimer related by a pseudo-twofold axis (see picture). PubMed: 29710967 DOI: 10.1002/(SICI)1521-3773(19980918)37:17<2381::AID-ANIE2381>3.0.CO;2-L PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.94 Å)

Structure validation