7YDT
 
 | | Crystal structure of mouse MPND | | Descriptor: | MPN domain containing protein | | Authors: | Yang, M, Chen, Z. | | Deposit date: | 2022-07-04 | | Release date: | 2023-02-15 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.055 Å) | | Cite: | Structures of MPND Reveal the Molecular Recognition of Nucleosomes.
Int J Mol Sci, 24, 2023
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7YDW
 | | Crystal structure of the MPND-DNA complex | | Descriptor: | DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MPN domain-containing protein | | Authors: | Yang, M, Chen, Z. | | Deposit date: | 2022-07-04 | | Release date: | 2023-02-15 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Structures of MPND Reveal the Molecular Recognition of Nucleosomes.
Int J Mol Sci, 24, 2023
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4JDL
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4JDA
 | | Complex structure of abscisic acid receptor PYL3 with (-)-ABA | | Descriptor: | (2Z,4E)-5-[(1R)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYL3 | | Authors: | Zhang, X, Wang, G, Chen, Z. | | Deposit date: | 2013-02-24 | | Release date: | 2013-07-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural Insights into the Abscisic Acid Stereospecificity by the ABA Receptors PYR/PYL/RCAR
Plos One, 8, 2013
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7X3W
 | | Cryo-EM structure of ISW1-N1 nucleosome | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (146-MER), ... | | Authors: | Lifei, L, Kangjing, C, Chen, Z. | | Deposit date: | 2022-03-01 | | Release date: | 2023-09-20 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure of the ISW1a complex bound to the dinucleosome.
Nat.Struct.Mol.Biol., 31, 2024
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7X3V
 | | Cryo-EM structure of IOC3-N2 nucleosome | | Descriptor: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Lifei, L, Kangjing, C, Chen, Z. | | Deposit date: | 2022-03-01 | | Release date: | 2023-09-20 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structure of the ISW1a complex bound to the dinucleosome.
Nat.Struct.Mol.Biol., 31, 2024
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7X3X
 | | Cryo-EM structure of N1 nucleosome-RA | | Descriptor: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Lifei, L, Kangjing, C, Chen, Z. | | Deposit date: | 2022-03-01 | | Release date: | 2023-09-20 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the ISW1a complex bound to the dinucleosome.
Nat.Struct.Mol.Biol., 31, 2024
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7X3T
 | | Cryo-EM structure of ISW1a-dinucleosome | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (343-MER), ... | | Authors: | Lifei, L, Kangjing, C, Chen, Z. | | Deposit date: | 2022-03-01 | | Release date: | 2023-09-20 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (5.4 Å) | | Cite: | Structure of the ISW1a complex bound to the dinucleosome.
Nat.Struct.Mol.Biol., 31, 2024
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5EDK
 | | Crystal structure of prothrombin deletion mutant residues 146-167 ( Form II ). | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... | | Authors: | Pozzi, N, Chen, Z, Di Cera, E. | | Deposit date: | 2015-10-21 | | Release date: | 2016-01-20 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.214 Å) | | Cite: | How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin.
J.Biol.Chem., 291, 2016
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4N0N
 | | Crystal structure of Arterivirus nonstructural protein 10 (helicase) | | Descriptor: | MAGNESIUM ION, Replicase polyprotein 1ab, SULFATE ION, ... | | Authors: | Deng, Z, Chen, Z. | | Deposit date: | 2013-10-02 | | Release date: | 2014-01-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.
Nucleic Acids Res., 42, 2014
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4N0O
 | | Complex structure of Arterivirus nonstructural protein 10 (helicase) with DNA | | Descriptor: | CALCIUM ION, DNA, Replicase polyprotein 1ab, ... | | Authors: | Deng, Z, Chen, Z. | | Deposit date: | 2013-10-02 | | Release date: | 2014-01-08 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.
Nucleic Acids Res., 42, 2014
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4ZVV
 | | Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140 | | Descriptor: | (2~{R})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Li, Y, Chen, Z, Eigenbrot, C. | | Deposit date: | 2015-05-18 | | Release date: | 2016-05-18 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat.Chem.Biol., 12, 2016
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4HZH
 | | Structure of recombinant Gla-domainless prothrombin mutant S525A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin | | Authors: | Pozzi, N, Niu, W, Gohara, D.W, Chen, Z, Di Cera, E. | | Deposit date: | 2012-11-15 | | Release date: | 2013-06-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation.
J.Biol.Chem., 288, 2013
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4O68
 | | Structure of human cyclic GMP-AMP synthase (cGAS) | | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | | Authors: | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | | Deposit date: | 2013-12-20 | | Release date: | 2014-02-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.436 Å) | | Cite: | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
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4O67
 | | Human cyclic GMP-AMP synthase (cGAS) in complex with GAMP | | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION, cGAMP | | Authors: | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | | Deposit date: | 2013-12-20 | | Release date: | 2014-02-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.444 Å) | | Cite: | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
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4O69
 | | Human cyclic GMP-AMP synthase (cGAS) in complex with sulfate ion | | Descriptor: | Cyclic GMP-AMP synthase, SULFATE ION, ZINC ION | | Authors: | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | | Deposit date: | 2013-12-20 | | Release date: | 2014-02-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.252 Å) | | Cite: | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
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4O6A
 | | Mouse cyclic GMP-AMP synthase (cGAS) in complex with DNA | | Descriptor: | Cyclic GMP-AMP synthase, DNA1, DNA2, ... | | Authors: | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | | Deposit date: | 2013-12-20 | | Release date: | 2014-02-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.859 Å) | | Cite: | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6, 2014
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8HB2
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8HBB
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8HAZ
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5CI6
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7Y35
 | | Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex | | Descriptor: | Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | | Deposit date: | 2022-06-09 | | Release date: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
To Be Published
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7Y36
 | | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HYDROXIDE ION, ... | | Authors: | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | | Deposit date: | 2022-06-10 | | Release date: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
to be published
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2OD3
 | | Human thrombin chimera with human residues 184a, 186, 186a, 186b, 186c and 222 replaced by murine thrombin equivalents. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Thrombin heavy chain, ... | | Authors: | Marino, F, Chen, Z, Ergenekan, C.E, Bush, L.A, Mathews, F.S, Di Cera, E. | | Deposit date: | 2006-12-21 | | Release date: | 2007-04-10 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural basis of na+ activation mimicry in murine thrombin.
J.Biol.Chem., 282, 2007
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7Y9I
 | | Complex structure of AtYchF1 with ppGpp | | Descriptor: | GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION, Obg-like ATPase 1 | | Authors: | Li, X, Chen, Z. | | Deposit date: | 2022-06-24 | | Release date: | 2023-07-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Co-crystalization reveals the interaction between AtYchF1 and ppGpp.
Front Mol Biosci, 9, 2022
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