8JDQ
 
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxyisocaproic acid | | 分子名称: | (2R)-2-hydroxy-4-methylpentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDT
 | | Crystal structure of mLDHD in complex with 2-ketobutanoic acid | | 分子名称: | 2-KETOBUTYRIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDC
 | | Crystal structure of mLDHD in apo form | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, mitochondrial | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-13 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDO
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxyhexanoic acid | | 分子名称: | (2R)-2-hydroxyhexanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDU
 | | Crystal structure of mLDHD in complex with 2-ketovaleric acid | | 分子名称: | 2-oxopentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDX
 | | Crystal structure of mLDHD in complex with 2-ketoisovaleric acid | | 分子名称: | 3-METHYL-2-OXOBUTANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDD
 | | Crystal structure of H405A mLDHD in apo form | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, mitochondrial | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-13 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDF
 | | Crystal structure of H405A mLDHD in complex with D-lactate | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, LACTIC ACID, Probable D-lactate dehydrogenase, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-13 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDS
 | | Crystal structure of mLDHD in complex with Pyruvate | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, PYRUVIC ACID, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.636 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDE
 | | Crystal structure of mLDHD in complex with D-lactate | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, LACTIC ACID, MANGANESE (II) ION, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-13 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.729 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDP
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxyisovaleric acid | | 分子名称: | DEAMINOHYDROXYVALINE, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDY
 | | Crystal structure of mLDHD in complex with 2-ketoisocaproic acid | | 分子名称: | 2-OXO-4-METHYLPENTANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDV
 | | Crystal structure of mLDHD in complex with 2-ketohexanoic acid | | 分子名称: | 2-Ketohexanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDZ
 | | Crystal structure of mLDHD in complex with 2-keto-3-methylvaleric acid | | 分子名称: | (3S)-3-methyl-2-oxopentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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7CN9
 | | Cryo-EM structure of SARS-CoV-2 Spike ectodomain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ho, M, Chang, Y, Wang, C, Wu, Y, Huang, H, Chen, T, Lo, J.M, Chen, X, Ma, C. | | 登録日 | 2020-07-30 | | 公開日 | 2020-08-26 | | 最終更新日 | 2021-03-10 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2.
Cell Rep, 32, 2020
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7VKO
 | | Crystal structure of TrkA kinase with repotrectinib | | 分子名称: | Repotrectinib, SULFATE ION, Tyrosine-protein kinase receptor | | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | | 登録日 | 2021-09-30 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations.
Mol.Cancer Ther., 20, 2021
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7VKM
 | | Crystal structure of TrkA (G595R) kinase domain | | 分子名称: | Tyrosine-protein kinase receptor | | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | | 登録日 | 2021-09-30 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations.
Mol.Cancer Ther., 20, 2021
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7VKN
 | | Crystal structure of TrkA (G595R) kinase with repotrectinib | | 分子名称: | Repotrectinib, SULFATE ION, Tyrosine-protein kinase receptor | | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | | 登録日 | 2021-09-30 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations.
Mol.Cancer Ther., 20, 2021
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7W6V
 | | Crystal structure of a dicobalt-substituted small laccase at 2.47 angstrom | | 分子名称: | COBALT (II) ION, Putative copper oxidase | | 著者 | Yang, X, Wu, F, Wu, W, Chen, X, Fan, S, Yu, P, Mao, L. | | 登録日 | 2021-12-02 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | A versatile artificial metalloenzyme scaffold enabling direct bioelectrocatalysis in solution.
Sci Adv, 8, 2022
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5ZHY
 | | Structural characterization of the HCoV-229E fusion core | | 分子名称: | Spike glycoprotein | | 著者 | Zhang, W, Zheng, Q, Yan, M, Chen, X, Yang, H, Zhou, W, Rao, Z. | | 登録日 | 2018-03-13 | | 公開日 | 2018-06-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.441 Å) | | 主引用文献 | Structural characterization of the HCoV-229E fusion core.
Biochem. Biophys. Res. Commun., 497, 2018
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6L03
 | | structure of PTP-MEG2 and MUNC18-1-pY145 peptide complex | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 9, stxbp1-pY145 peptide | | 著者 | Xu, Y.F, Chen, X, Yu, X, Sun, J.P. | | 登録日 | 2019-09-25 | | 公開日 | 2020-09-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.084 Å) | | 主引用文献 | PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.
Embo Rep., 22, 2021
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6KZQ
 | | structure of PTP-MEG2 and NSF-pY83 peptide complex | | 分子名称: | NSF-pY83 peptide, Tyrosine-protein phosphatase non-receptor type 9 | | 著者 | Xu, Y.F, Chen, X, Yu, X, Sun, J.P. | | 登録日 | 2019-09-25 | | 公開日 | 2020-09-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.
Embo Rep., 22, 2021
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6IHI
 | | Crystal structure of RasADH 3B3/I91V from Ralstonia.sp in complex with NADPH and A6O | | 分子名称: | (2R,3S)-2-ethyl-2-[(2E)-2-(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)ethyl]-3-oxidanyl-cyclopentan-1-one, Alclohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Zhang, H.L, Chen, X, Liu, W.D, Wu, Q.Q, Zhu, D.M. | | 登録日 | 2018-09-30 | | 公開日 | 2019-10-02 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase.
Nat Catal, 2, 2019
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6IHH
 | | Crystal structure of RasADH F12 from Ralstonia.sp in complex with NADPH and A6O | | 分子名称: | (2R,3S)-2-ethyl-2-[(2E)-2-(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)ethyl]-3-oxidanyl-cyclopentan-1-one, Alclohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Zhang, H.L, Chen, X, Liu, W.D, Wu, Q.Q, Zhu, D.M. | | 登録日 | 2018-09-30 | | 公開日 | 2019-10-02 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase.
Nat Catal, 2, 2019
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6L6H
 | | Crystal structure of Lpg0189 | | 分子名称: | ACETATE ION, GLYCEROL, Uncharacterized protein Lpg0189 | | 著者 | Ge, H, Chen, X. | | 登録日 | 2019-10-29 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.403 Å) | | 主引用文献 | Crystal structure of a hypothetical T2SS effector Lpg0189 from Legionella pneumophila reveals a novel protein fold.
Biochem.Biophys.Res.Commun., 521, 2020
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