7Y72
| SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7 (focused refinement on Fab-RBD interface) | 分子名称: | Fab E7 heavy chain, Fab E7 light chain, Spike glycoprotein | 著者 | Chia, W.N, Tan, C.W, Tan, A.W.K, Young, B, Starr, T.N, Lopez, E, Fibriansah, G, Barr, J, Cheng, S, Yeoh, A.Y.Y, Yap, W.C, Lim, B.L, Ng, T.S, Sia, W.R, Zhu, F, Chen, S, Zhang, J, Greaney, A.J, Chen, M, Au, G.G, Paradkar, P, Peiris, M, Chung, A.W, Bloom, J.D, Lye, D, Lok, S.M, Wang, L.F. | 登録日 | 2022-06-21 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | 主引用文献 | Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor. Sci Adv, 9, 2023
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4MSU
| Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate | 分子名称: | 1,1,1,3,3,3-hexafluoro-2-{4-[4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | 著者 | Ashton, K.S, Andrews, K.L, Bryan, M.C, Chen, J, Chen, K, Chen, M, Chmait, S, Croghan, M, Cupples, R, Fotsch, C, Helmering, J, Jordan, S.R, Kurzeja, R.J, Michelsen, K, Pennington, L.D, Poon, S.F, Sivits, G, Van, G, Vonderfecht, S.L, Wahl, R.C, Zhang, J, Lloyd, D.J, Hale, C, St Jean, D.J. | 登録日 | 2013-09-18 | 公開日 | 2014-03-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept. J.Med.Chem., 57, 2014
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8JAY
| CrtSPARTA Octamer bound with guide-target | 分子名称: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | 著者 | Guo, L.J, Huang, P.P, Li, Z.X, Xiao, Y.B, Chen, M.R. | 登録日 | 2023-05-07 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system. Nat.Chem.Biol., 20, 2024
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2X7J
| Structure of the menaquinone biosynthesis protein MenD from Bacillus subtilis | 分子名称: | 1,2-ETHANEDIOL, 2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE -1-CARBOXYLATE SYNTHASE, MANGANESE (II) ION, ... | 著者 | Dawson, A, Chen, M, Fyfe, P.K, Guo, Z, Hunter, W.N. | 登録日 | 2010-03-01 | 公開日 | 2010-07-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structure and Reactivity of Bacillus Subtilis Mend Catalyzing the First Committed Step in Menaquinone Biosynthesis. J.Mol.Biol., 401, 2010
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7YTF
| Structure of OCPx2 from Nostoc flagelliforme CCNUN1 | 分子名称: | Ketosteroid isomerase-related protein, beta,beta-carotene-4,4'-dione | 著者 | Yang, Y.W, Chen, S.Z, Liu, K, Chen, M, Qiu, B.S. | 登録日 | 2022-08-14 | 公開日 | 2023-06-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Functional specialization of expanded orange carotenoid protein paralogs in subaerial Nostoc species. Plant Physiol., 192, 2023
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7YTH
| Structure of OCPx1 from Nostoc flagelliforme CCNUN1 | 分子名称: | Ketosteroid isomerase-related protein | 著者 | Yang, Y.W, Liu, K, Chen, S.Z, Chen, M, Qiu, B.S. | 登録日 | 2022-08-14 | 公開日 | 2023-06-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Functional specialization of expanded orange carotenoid protein paralogs in subaerial Nostoc species. Plant Physiol., 192, 2023
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1A8M
| TUMOR NECROSIS FACTOR ALPHA, R31D MUTANT | 分子名称: | TUMOR NECROSIS FACTOR ALPHA | 著者 | Reed, C, Fu, Z.-Q, Wu, J, Xue, Y.-N, Harrison, R.W, Chen, M.-J, Weber, I.T. | 登録日 | 1998-03-27 | 公開日 | 1998-06-17 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2. Protein Eng., 10, 1997
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8J8H
| SPARTA monomer bound with guide-target, state 2 | 分子名称: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | 著者 | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | 登録日 | 2023-05-01 | 公開日 | 2024-03-06 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system. Nat.Chem.Biol., 20, 2024
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8J9P
| SPARTA dimer bound with guide-target | 分子名称: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | 著者 | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | 登録日 | 2023-05-04 | 公開日 | 2024-03-06 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system. Nat.Chem.Biol., 20, 2024
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8J9G
| CrtSPARTA hetero-dimer bound with guide-target, state 1 | 分子名称: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | 著者 | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | 登録日 | 2023-05-03 | 公開日 | 2024-03-06 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system. Nat.Chem.Biol., 20, 2024
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8J84
| Short ago complexed with TIR-APAZ | 分子名称: | Piwi domain-containing protein, TIR domain-containing protein | 著者 | Guo, L.J, Huang, P.P, Li, Z.X, Xiao, Y.B, Chen, M.R. | 登録日 | 2023-04-30 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system. Nat.Chem.Biol., 20, 2024
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6PT0
| Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2 | 分子名称: | CHOLESTEROL, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, T.H, Xing, C, Zhuang, Y, Feng, Z, Zhou, X.E, Chen, M, Wang, L, Meng, X, Xue, Y, Wang, J, Liu, H, McGuire, T, Zhao, G, Melcher, K, Zhang, C, Xu, H.E, Xie, X.Q. | 登録日 | 2019-07-14 | 公開日 | 2020-02-12 | 最終更新日 | 2020-03-04 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM Structure of the Human Cannabinoid Receptor CB2-GiSignaling Complex. Cell, 180, 2020
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5WSL
| Structural studies of keratinase from Meiothermus taiwanensis WR-220 | 分子名称: | CALCIUM ION, SULFATE ION, keratinase | 著者 | Ho, M.C, Wu, S.H, Chen, M.Y, Tu, I.F. | 登録日 | 2016-12-07 | 公開日 | 2017-10-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The discovery of novel heat-stable keratinases from Meiothermus taiwanensis WR-220 and other extremophiles Sci Rep, 7, 2017
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8FR7
| A hinge glycan regulates spike bending and impacts coronavirus infectivity | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Pintilie, G, Wilson, E, Chmielewski, D, Schmid, M.F, Jin, J, Chen, M, Singharoy, A, Chiu, W. | 登録日 | 2023-01-06 | 公開日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | A hinge glycan regulates spike bending and impacts coronavirus infectivity To Be Published
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5XU1
| Structure of a non-canonical ABC transporter from Streptococcus pneumoniae R6 | 分子名称: | ABC transporter ATP-binding protein, ABC transporter permeae, MAGNESIUM ION | 著者 | Yang, H.B, Jiang, Y.L, Hou, W.T, Chen, M.T, Chen, Y, Zhou, C.Z. | 登録日 | 2017-06-22 | 公開日 | 2018-01-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of a MacAB-like efflux pump from Streptococcus pneumoniae. Nat Commun, 9, 2018
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6AKK
| Crystal structure of the second Coiled-coil domain of SIKE1 | 分子名称: | GLYCEROL, Suppressor of IKBKE 1 | 著者 | Zhou, L, Chen, M, Zhou, Z.C. | 登録日 | 2018-09-02 | 公開日 | 2019-01-16 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discov, 5, 2019
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4H00
| The crystal structure of mon-Zn dihydropyrimidinase from Tetraodon nigroviridis | 分子名称: | ZINC ION, dihydropyrimidinase | 著者 | Hsieh, Y.C, Chen, M.C, Hsu, C.C, Chan, S.I, Yang, Y.S, Chen, C.J. | 登録日 | 2012-09-06 | 公開日 | 2013-09-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Lysine Carboxylation: Metal and Structural Requirements for Post-translational Modification To be Published
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4GZ7
| The crystal structure of Apo-dihydropyrimidinase from Tetraodon nigroviridis | 分子名称: | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, dihydropyrimidinase | 著者 | Hsien, Y.C, Chen, M.C, Hsu, C.C, Chan, S.I, Yang, Y.S, Chen, C.J. | 登録日 | 2012-09-06 | 公開日 | 2013-09-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Lysine Carboxylation: Metal and Structure Requirements for Post-translational Modification To be Published
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4H01
| The crystal structure of di-Zn dihydropyrimidinase from Tetraodon nigroviridis | 分子名称: | ZINC ION, dihydropyrimidinase | 著者 | Hsieh, Y.C, Chen, M.C, Hsu, C.C, Chan, S.I, Yang, Y.S, Chen, C.J. | 登録日 | 2012-09-06 | 公開日 | 2013-09-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Lysine Carboxylation: Metal and Structural Requirements for Post-translational Modification To be Published
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8FCG
| Cryo-EM structure of Chikungunya virus asymmetric unit | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Capsid protein, E1 glycoprotein, ... | 著者 | Su, G.C, Chmielewsk, D, Kaelber, J, Pintilie, G, Chen, M, Jin, J, Auguste, A, Chiu, W. | 登録日 | 2022-12-01 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Cryogenic electron microscopy and tomography reveal imperfect icosahedral symmetry in alphaviruses. Pnas Nexus, 3, 2024
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6L30
| Crystal structure of the epithelial cell transforming 2 (ECT2) | 分子名称: | Protein ECT2 | 著者 | Chen, Z.C, Chen, M.R, Pan, H, Sun, L.F, Shi, P. | 登録日 | 2019-10-07 | 公開日 | 2020-01-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure and regulation of human epithelial cell transforming 2 protein. Proc.Natl.Acad.Sci.USA, 117, 2020
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5ZTB
| Structure of Sulfurtransferase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, IRON/SULFUR CLUSTER, ... | 著者 | Tanaka, Y, Chen, M, Narai, S, Yao, M. | 登録日 | 2018-05-02 | 公開日 | 2019-06-12 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The [4Fe-4S] cluster of sulfurtransferase TtuA desulfurizes TtuB during tRNA modification in Thermus thermophilus. Commun Biol, 3, 2020
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5ZVL
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4LCQ
| The crystal structure of di-Zn dihydropyrimidinase in complex with NCBI | 分子名称: | (2S)-3-(carbamoylamino)-2-methylpropanoic acid, ZINC ION, dihydropyrimidinase | 著者 | Hsieh, Y.C, Chen, M.C, Hsu, C.C, Chan, S.I, Yang, Y.S, Chen, C.J. | 登録日 | 2013-06-22 | 公開日 | 2013-09-18 | 最終更新日 | 2014-02-12 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Crystal structures of vertebrate dihydropyrimidinase and complexes from Tetraodon nigroviridis with lysine carbamylation: metal and structural requirements for post-translational modification and function. J.Biol.Chem., 288, 2013
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4LCR
| The crystal structure of di-Zn dihydropyrimidinase in complex with NCBA | 分子名称: | Chromosome 8 SCAF14545, whole genome shotgun sequence, N-(AMINOCARBONYL)-BETA-ALANINE, ... | 著者 | Hsieh, Y.C, Chen, M.C, Hsu, C.C, Chan, S.I, Yang, Y.S, Chen, C.J. | 登録日 | 2013-06-22 | 公開日 | 2013-09-18 | 最終更新日 | 2014-02-12 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of vertebrate dihydropyrimidinase and complexes from Tetraodon nigroviridis with lysine carbamylation: metal and structural requirements for post-translational modification and function. J.Biol.Chem., 288, 2013
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