4MSU

Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate

Summary for 4MSU

Entry DOI	10.2210/pdb4msu/pdb
Descriptor	Glucokinase regulatory protein, 1,1,1,3,3,3-hexafluoro-2-{4-[4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
Functional Keywords	sis domains, regulatory protein, glucokinase, phospho-fructose, sugar binding protein
Biological source	Homo sapiens (human)
Cellular location	Nucleus (By similarity): Q14397
Total number of polymer chains	2
Total formula weight	145033.18
Authors	Ashton, K.S.,Andrews, K.L.,Bryan, M.C.,Chen, J.,Chen, K.,Chen, M.,Chmait, S.,Croghan, M.,Cupples, R.,Fotsch, C.,Helmering, J.,Jordan, S.R.,Kurzeja, R.J.,Michelsen, K.,Pennington, L.D.,Poon, S.F.,Sivits, G.,Van, G.,Vonderfecht, S.L.,Wahl, R.C.,Zhang, J.,Lloyd, D.J.,Hale, C.,St Jean, D.J. (deposition date: 2013-09-18, release date: 2014-03-12, Last modification date: 2024-02-28)
Primary citation	Ashton, K.S.,Andrews, K.L.,Bryan, M.C.,Chen, J.,Chen, K.,Chen, M.,Chmait, S.,Croghan, M.,Cupples, R.,Fotsch, C.,Helmering, J.,Jordan, S.R.,Kurzeja, R.J.,Michelsen, K.,Pennington, L.D.,Poon, S.F.,Sivits, G.,Van, G.,Vonderfecht, S.L.,Wahl, R.C.,Zhang, J.,Lloyd, D.J.,Hale, C.,St Jean, D.J. Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept. J.Med.Chem., 57:309-324, 2014 Cited by PubMed: 24405172 DOI: 10.1021/jm4016735 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation