4MSU

Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glucokinase regulatory protein	polymer	636	70178.5	2	UniProt (Q14397) Pfam (PF22645) Pfam (PF22198) Pfam (PF20741)	Homo sapiens (human)	Glucokinase regulator
2	C, Q (A, B)	1,1,1,3,3,3-hexafluoro-2-{4-[4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol	non-polymer		474.4	2	Chemie (2EU)
3	D, R (A, B)	D-SORBITOL-6-PHOSPHATE	non-polymer		262.2	2	Chemie (S6P)
4	AA, BA, CA, DA, E... (B, A)	IODIDE ION	non-polymer		126.9	23	Chemie (IOD)
5	P (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	EA, FA (B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7	GA, HA (A, B)	water	water		18.0	56	Chemie (HOH)

Sequence modifications

A, B: 1 - 625 (UniProt: Q14397)

PDB	External Database	Details
Met -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Asp -3	-	expression tag
Glu -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	140357.0
Non-Polymers*	Number of molecules	30
	Total formula weight	4676.2
All*	Total formula weight	145033.2

*Water molecules are not included.