3MCA
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5ZBG
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5YX9
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4HOM
| Crystal structure of porcine aminopeptidase-N complexed with substance P | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, L, Lin, Y.L, Peng, G, Li, F. | Deposit date: | 2012-10-22 | Release date: | 2012-10-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc.Natl.Acad.Sci.USA, 109, 2012
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4NAQ
| Crystal structure of porcine aminopeptidase-N complexed with poly-alanine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | Authors: | Chen, L, Lin, Y.L, Peng, G, Li, F. | Deposit date: | 2013-10-22 | Release date: | 2013-12-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc.Natl.Acad.Sci.USA, 109, 2012
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4NZ8
| Crystal structure of porcine aminopeptidase-N complexed with cleaved poly-alanine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | Authors: | Chen, L, Lin, Y.L, Peng, G, Li, F. | Deposit date: | 2013-12-11 | Release date: | 2013-12-25 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc.Natl.Acad.Sci.USA, 109, 2012
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7E3X
| Crystal structure of SDR family NAD(P)-dependent oxidoreductase from exiguobacterium | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase | Authors: | Chen, L, Tang, J, Yuan, S, Zhang, F, Chen, S. | Deposit date: | 2021-02-09 | Release date: | 2021-09-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters Catalysis Science And Technology, 2021
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4U1W
| Full length GluA2-kainate-(R,R)-2b complex crystal form A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, ... | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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6JT0
| Structure of human soluble guanylate cyclase in the unliganded state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | Deposit date: | 2019-04-08 | Release date: | 2019-08-28 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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6JT1
| Structure of human soluble guanylate cyclase in the heme oxidised state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | Deposit date: | 2019-04-08 | Release date: | 2019-08-28 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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8HBW
| Structure of human UCP1 in the ATP-bound state | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CARDIOLIPIN, ... | Authors: | Chen, L, Kang, Y. | Deposit date: | 2022-10-31 | Release date: | 2023-06-21 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature, 620, 2023
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8HBV
| Structure of human UCP1 in the nucleotide-free state | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CARDIOLIPIN, Mitochondrial brown fat uncoupling protein 1, ... | Authors: | Chen, L, Kang, Y. | Deposit date: | 2022-10-31 | Release date: | 2023-06-21 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.51 Å) | Cite: | Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature, 620, 2023
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8HBH
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8HBE
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8HBF
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8J1N
| Structure of human UCP1 in the DNP-bound state | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,4-DINITROPHENOL, CARDIOLIPIN, ... | Authors: | Chen, L, Kang, Y. | Deposit date: | 2023-04-13 | Release date: | 2023-06-21 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.51 Å) | Cite: | Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature, 620, 2023
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5CCU
| Crystal structure of endoglycoceramidase I from Rhodococ-cus equi | Descriptor: | 1,2-ETHANEDIOL, Putative secreted endoglycosylceramidase, SODIUM ION | Authors: | Chen, L. | Deposit date: | 2015-07-02 | Release date: | 2015-09-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structural Insights into the Broad Substrate Specificity of a Novel Endoglycoceramidase I Belonging to a New Subfamily of GH5 Glycosidases J. Biol. Chem., 292, 2017
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8GXE
| PTPN21 FERM PTP complex | Descriptor: | CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21 | Authors: | Chen, L, Zheng, Y.Y, Zhou, C. | Deposit date: | 2022-09-19 | Release date: | 2023-09-27 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
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8GWH
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8GVV
| PTPN21 PTP domain C1108S mutant | Descriptor: | IODIDE ION, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 21 | Authors: | Chen, L, Zheng, Y.Y, Zhou, C. | Deposit date: | 2022-09-15 | Release date: | 2023-09-20 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
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8GVL
| PTPN21 FERM | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Tyrosine-protein phosphatase non-receptor type 21 | Authors: | Chen, L, Zheng, Y.Y, Zhou, C. | Deposit date: | 2022-09-15 | Release date: | 2023-09-20 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
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7VLS
| Structure of SUR2B in complex with MgATP/ADP and P1075 | Descriptor: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, L, Ding, D. | Deposit date: | 2021-10-05 | Release date: | 2022-05-18 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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7VLT
| Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim | Descriptor: | (3S,4R)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, L, Ding, D. | Deposit date: | 2021-10-05 | Release date: | 2022-05-18 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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7VLU
| Structure of SUR2A in complex with Mg-ATP/ADP and P1075 | Descriptor: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, L, Ding, D. | Deposit date: | 2021-10-05 | Release date: | 2022-05-18 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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7VLR
| Structure of SUR2B in complex with Mg-ATP/ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Chen, L, Ding, D. | Deposit date: | 2021-10-05 | Release date: | 2022-05-18 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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