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PDB: 550 results
8HBV
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BU of 8hbv by Molmil
Structure of human UCP1 in the nucleotide-free state
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CARDIOLIPIN, Mitochondrial brown fat uncoupling protein 1, ...
Authors:Chen, L, Kang, Y.
Deposit date:2022-10-31
Release date:2023-06-21
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (2.51 Å)
Cite:Structural basis for the binding of DNP and purine nucleotides onto UCP1.
Nature, 620, 2023
8HBW
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BU of 8hbw by Molmil
Structure of human UCP1 in the ATP-bound state
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CARDIOLIPIN, ...
Authors:Chen, L, Kang, Y.
Deposit date:2022-10-31
Release date:2023-06-21
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural basis for the binding of DNP and purine nucleotides onto UCP1.
Nature, 620, 2023
5ZBG
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BU of 5zbg by Molmil
Cryo-EM structure of human TRPC3 at 4.36A resolution
Descriptor: Short transient receptor potential channel 3
Authors:Chen, L, Tang, Q, Guo, W.
Deposit date:2018-02-11
Release date:2018-05-09
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.36 Å)
Cite:Structure of the receptor-activated human TRPC6 and TRPC3 ion channels
Cell Res., 28, 2018
3WQW
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BU of 3wqw by Molmil
Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain in complex with a(GlcN)6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Chen, L, Zhou, Y, Yang, Q.
Deposit date:2014-02-03
Release date:2014-05-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fully deacetylated chitooligosaccharides act as efficient glycoside hydrolase family 18 chitinase inhibitors.
J.Biol.Chem., 289, 2014
5YX9
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BU of 5yx9 by Molmil
Cryo-EM structure of human TRPC6 at 3.8A resolution
Descriptor: Short transient receptor potential channel 6
Authors:Chen, L, Tang, Q, Guo, W.
Deposit date:2017-12-02
Release date:2018-05-23
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the receptor-activated human TRPC6 and TRPC3 ion channels.
Cell Res., 28, 2018
3WQV
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BU of 3wqv by Molmil
Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain in complex with a(GlcN)5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Chen, L, Zhou, Y, Yang, Q.
Deposit date:2014-02-03
Release date:2014-05-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.043 Å)
Cite:Fully deacetylated chitooligosaccharides act as efficient glycoside hydrolase family 18 chitinase inhibitors.
J.Biol.Chem., 289, 2014
4EAI
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BU of 4eai by Molmil
Co-crystal structure of an AMPK core with AMP
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.285 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EAK
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BU of 4eak by Molmil
Co-crystal structure of an AMPK core with ATP
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EAJ
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BU of 4eaj by Molmil
Co-crystal of AMPK core with AMP soaked with ATP
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.609 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EP4
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BU of 4ep4 by Molmil
Thermus thermophilus RuvC structure
Descriptor: Crossover junction endodeoxyribonuclease RuvC, GLYCEROL, MAGNESIUM ION
Authors:Chen, L, Shi, K, Yin, Z.Q, Aihara, H.
Deposit date:2012-04-17
Release date:2012-11-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Structural asymmetry in the Thermus thermophilus RuvC dimer suggests a basis for sequential strand cleavages during Holliday junction resolution.
Nucleic Acids Res., 41, 2013
4EAG
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BU of 4eag by Molmil
Co-crystal structure of an chimeric AMPK core with ATP
Descriptor: 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EAL
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BU of 4eal by Molmil
Co-crystal of AMPK core with ATP soaked with AMP
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EP5
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BU of 4ep5 by Molmil
Thermus thermophilus RuvC structure
Descriptor: Crossover junction endodeoxyribonuclease RuvC, GLYCEROL, SULFATE ION
Authors:Chen, L, Shi, K, Yin, Z.Q, Aihara, H.
Deposit date:2012-04-17
Release date:2012-11-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural asymmetry in the Thermus thermophilus RuvC dimer suggests a basis for sequential strand cleavages during Holliday junction resolution.
Nucleic Acids Res., 41, 2013
4FKE
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BU of 4fke by Molmil
Crystal structure of porcine aminopeptidase-N
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:2012-06-13
Release date:2012-10-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for multifunctional roles of mammalian aminopeptidase N.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FKH
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BU of 4fkh by Molmil
Crystal structure of porcine aminopeptidase-N complexed with alanine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:2012-06-13
Release date:2012-10-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for multifunctional roles of mammalian aminopeptidase N.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FKK
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BU of 4fkk by Molmil
Crystal structure of porcine aminopeptidase-N complexed with bestatin
Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:2012-06-13
Release date:2012-10-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for multifunctional roles of mammalian aminopeptidase N.
Proc.Natl.Acad.Sci.USA, 109, 2012
3H4J
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BU of 3h4j by Molmil
crystal structure of pombe AMPK KDAID fragment
Descriptor: SNF1-like protein kinase ssp2
Authors:Chen, L, Jiao, Z.-H, Zheng, L.-S, Zhang, Y.-Y, Xie, S.-T, Wang, Z.-X, Wu, J.-W.
Deposit date:2009-04-20
Release date:2009-06-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insight into the autoinhibition mechanism of AMP-activated protein kinase
Nature, 459, 2009
8J1N
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BU of 8j1n by Molmil
Structure of human UCP1 in the DNP-bound state
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,4-DINITROPHENOL, CARDIOLIPIN, ...
Authors:Chen, L, Kang, Y.
Deposit date:2023-04-13
Release date:2023-06-21
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (2.51 Å)
Cite:Structural basis for the binding of DNP and purine nucleotides onto UCP1.
Nature, 620, 2023
8GVL
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BU of 8gvl by Molmil
PTPN21 FERM
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-15
Release date:2023-09-20
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Sci Adv, 10, 2024
8GWH
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BU of 8gwh by Molmil
PTPN21 PTP domain C1108S mutant in complex with SRC pTyr530 peptide
Descriptor: SRC pTyr530 peptide, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-17
Release date:2023-09-20
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Sci Adv, 10, 2024
3JUA
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BU of 3jua by Molmil
Structural basis of YAP recognition by TEAD4 in the Hippo pathway
Descriptor: 65 kDa Yes-associated protein, Transcriptional enhancer factor TEF-3
Authors:Chen, L, Song, H.
Deposit date:2009-09-15
Release date:2010-02-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of YAP recognition by TEAD4 in the hippo pathway.
Genes Dev., 24, 2010
8GVV
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BU of 8gvv by Molmil
PTPN21 PTP domain C1108S mutant
Descriptor: IODIDE ION, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-15
Release date:2023-09-20
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Sci Adv, 10, 2024
8GXE
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BU of 8gxe by Molmil
PTPN21 FERM PTP complex
Descriptor: CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-19
Release date:2023-09-27
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Sci Adv, 10, 2024
2ICU
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BU of 2icu by Molmil
Crystal Structure of Hypothetical Protein YedK From Escherichia coli
Descriptor: Hypothetical protein yedK
Authors:Chen, L, Liu, Z.J, Li, Y, Zhao, M, Rose, J, Ebihara, A, Yokoyama, S, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-09-13
Release date:2006-11-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Hypothetical Protein YedK From Escherichia coli
To be Published
2JTK
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BU of 2jtk by Molmil
A functional domain of a Wnt signal protein
Descriptor: Dickkopf-related protein 2
Authors:Chen, L, Shao, Y, Huang, J, Zheng, J.
Deposit date:2007-08-02
Release date:2008-07-08
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural insight into the mechanisms of wnt signaling antagonism by dkk
J.Biol.Chem., 283, 2008

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