4HJE
 
 | | Crystal structure of p53 core domain in complex with DNA | | Descriptor: | Cellular tumor antigen p53, DNA (5'-D(*AP*GP*GP*CP*TP*TP*GP*TP*CP*TP*CP*TP*AP*AP*CP*TP*TP*GP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*CP*AP*AP*GP*TP*TP*AP*GP*AP*GP*AP*CP*AP*AP*GP*CP*CP*T)-3'), ... | | Authors: | Chen, Y, Chen, L. | | Deposit date: | 2012-10-12 | | Release date: | 2013-07-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.907 Å) | | Cite: | Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion.
Nucleic Acids Res., 41, 2013
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1PL5
 | | Crystal Structure Analysis of the Sir4p C-terminal Coiled Coil | | Descriptor: | Regulatory protein SIR4 | | Authors: | Murphy, G.A, Spedale, E.J, Powell, S.T, Pillus, L, Schultz, S.C, Chen, L. | | Deposit date: | 2003-06-06 | | Release date: | 2004-06-01 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The Sir4 C-terminal coiled coil is required for telomeric and mating type silencing in Saccharomyces cerevisiae.
J.Mol.Biol., 334, 2003
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4OIV
 | | Structural basis for small molecule NDB as a selective antagonist of FXR | | Descriptor: | Bile acid receptor, N-benzyl-N-(3-tert-butyl-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino)benzamide | | Authors: | Xu, X, Chen, L, Hu, L, Shen, X. | | Deposit date: | 2014-01-20 | | Release date: | 2015-03-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha ) in Stabilizing the Homodimerization of the Receptor.
J.Biol.Chem., 290, 2015
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1RYJ
 | | Solution NMR Structure of Protein Mth1743 from Methanobacterium thermoautotrophicum. Ontario Centre for Structural Proteomics target MTH1743_1_70; Northeast Structural Genomics Consortium Target TT526. | | Descriptor: | unknown | | Authors: | Yee, A, Chang, X, Pineda-Lucena, A, Wu, B, Semesi, A, Le, B, Ramelot, T, Lee, G.M, Bhattacharyya, S, Gutierrez, P, Denisov, A, Lee, C.H, Cort, J.R, Kozlov, G, Liao, J, Finak, G, Chen, L, Wishart, D, Lee, W, McIntosh, L.P, Gehring, K, Kennedy, M.A, Edwards, A.M, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2003-12-22 | | Release date: | 2004-02-24 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | AN NMR APPROACH TO STRUCTURAL PROTEOMICS
Proc.Natl.Acad.Sci.USA, 99, 2002
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2EB2
 | | Crystal structure of mutated EGFR kinase domain (G719S) | | Descriptor: | Epidermal growth factor receptor | | Authors: | Yoshikawa, S, Kukimoto-Niino, M, Chen, L, Liu, Z.J, Wang, B.C, Shirouzu, M, Senba, K, Yamamoto, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-06 | | Release date: | 2008-02-12 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor
Oncogene, 2012
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2DYY
 | | Crystal structure of putative translation initiation inhibitor PH0854 from Pyrococcus horikoshii | | Descriptor: | UPF0076 protein PH0854 | | Authors: | Ihsanawati, Kishishita, S, Murayama, K, Chen, L, Liu, Z.J, Wang, B.C, Shirouzu, M, Bessho, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-09-19 | | Release date: | 2007-03-19 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of putative translation initiation inhibitor PH0854 from Pyrococcus horikoshii
To be Published
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3N3Y
 | | Crystal structure of Thymidylate Synthase X (ThyX) from Helicobacter pylori with FAD and dUMP at 2.31A resolution | | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX | | Authors: | Wang, K, Wang, Q, Chen, J, Chen, L, Jiang, H, Shen, X. | | Deposit date: | 2010-05-21 | | Release date: | 2011-05-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.307 Å) | | Cite: | Structure, Enzymatic Characterization and Inhibitor Discovery of Thymidylate Synthase X (ThyX) from Helicobacter pylori Strain SS1
To be Published
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5E1J
 | | Structure of voltage-gated two-pore channel TPC1 from Arabidopsis thaliana | | Descriptor: | BARIUM ION, CALCIUM ION, Two pore calcium channel protein 1 | | Authors: | Guo, J, Zeng, W, Chen, Q, Lee, C, Chen, L, Yang, Y, Jiang, Y. | | Deposit date: | 2015-09-29 | | Release date: | 2015-12-16 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.308 Å) | | Cite: | Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana.
Nature, 531, 2016
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4YE4
 | | Crystal Structure of Neutralizing Antibody HJ16 in Complex with HIV-1 gp120 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HT593.1 gp120, Heavy chain human antibody HJ16, ... | | Authors: | Kwong, P.D, Chen, L, Zhou, T. | | Deposit date: | 2015-02-23 | | Release date: | 2015-07-22 | | Last modified: | 2022-03-30 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
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3QRF
 | | Structure of a domain-swapped FOXP3 dimer | | Descriptor: | Forkhead box protein P3, MAGNESIUM ION, Nuclear factor of activated T-cells, ... | | Authors: | Bandukwala, H.S, Wu, Y, Feurer, M, Chen, Y, Barbosa, B, Ghosh, S, Stroud, J.C, Benoist, C, Mathis, D, Rao, A, Chen, L. | | Deposit date: | 2011-02-17 | | Release date: | 2011-04-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.
Immunity, 34, 2011
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3R2A
 | | Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 and antagonist rhein | | Descriptor: | 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, Nuclear receptor corepressor 2, Retinoic acid receptor RXR-alpha | | Authors: | Zhang, H, Chen, L, Chen, J, Jiang, H, Shen, X. | | Deposit date: | 2011-03-14 | | Release date: | 2011-05-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis for retinoic x receptor repression on the tetramer.
J.Biol.Chem., 286, 2011
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2A4K
 | | 3-Oxoacyl-[acyl carrier protein] reductase from Thermus thermophilus TT0137 | | Descriptor: | 3-oxoacyl-[acyl carrier protein] reductase, UNKNOWN ATOM OR ION | | Authors: | Zhou, W, Ebihara, A, Tempel, W, Yokoyama, S, Chen, L, Kuramitsu, S, Nguyen, J, Chang, S.-H, Liu, Z.-J, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-06-29 | | Release date: | 2006-01-10 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | 3-Oxoacyl-[acyl carrier protein] reductase from Thermus thermophilus TT0137
To be Published
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4GOY
 | | The crystal structure of human fascin 1 K41A mutant | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BROMIDE ION, CHLORIDE ION, ... | | Authors: | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | | Deposit date: | 2012-08-20 | | Release date: | 2012-11-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Molecular mechanism of fascin function in filopodial formation.
J.Biol.Chem., 288, 2013
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8VY8
 | | Recombinant alpha bungarotoxin complexed with HAP peptide | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Alpha-bungarotoxin isoform V31, HAP peptide | | Authors: | Xu, J, Lei, X, Chen, L. | | Deposit date: | 2024-02-07 | | Release date: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of recombinant alpha bungarotoxin complexed with HAP peptide at 2.4 Angstroms resolution.
To Be Published
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4GP0
 | | The crystal structure of human fascin 1 R149A K150A R151A mutant | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BROMIDE ION, ... | | Authors: | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | | Deposit date: | 2012-08-20 | | Release date: | 2012-11-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Molecular mechanism of fascin function in filopodial formation.
J.Biol.Chem., 288, 2013
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4GP3
 | | The crystal structure of human fascin 1 K358A mutant | | Descriptor: | BROMIDE ION, CHLORIDE ION, Fascin, ... | | Authors: | Yang, S.Y, Huang, F.K, Huang, J, Chen, S, Jakoncic, J, Leo-Macias, A, Diaz-Avalos, R, Chen, L, Zhang, J.J, Huang, X.Y. | | Deposit date: | 2012-08-20 | | Release date: | 2012-11-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Molecular mechanism of fascin function in filopodial formation.
J.Biol.Chem., 288, 2013
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2P5U
 | | Crystal structure of Thermus thermophilus HB8 UDP-glucose 4-epimerase complex with NAD | | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-glucose 4-epimerase | | Authors: | Fu, Z.-Q, Chen, L, Ebihara, A, Shinkai, A, Kuramitsu, S, Yokoyama, S, Zhao, M, Dillard, B, Chrzas, J, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-16 | | Release date: | 2007-04-17 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Crystal structure of Thermus thermophilus HB8 UDP-glucose 4-epimerase complex with NAD
To be Published
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2CSL
 | | Crystal structure of TTHA0137 from Thermus Thermophilus HB8 | | Descriptor: | protein translation initiation inhibitor | | Authors: | Wang, H, Murayama, K, Terada, T, Chen, L, Jin, Z, Chrzas, J, Liu, Z.J, Wang, B.C, Shirouzu, M, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-05-22 | | Release date: | 2005-11-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of TTHA0137 from Thermus Thermophilus HB8
To be Published
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2DQB
 | | Crystal structure of dNTP triphosphohydrolase from Thermus thermophilus HB8, which is homologous to dGTP triphosphohydrolase | | Descriptor: | Deoxyguanosinetriphosphate triphosphohydrolase, putative, MAGNESIUM ION | | Authors: | Kondo, N, Nakagawa, N, Ebihara, A, Chen, L, Liu, Z.-J, Wang, B.-C, Yokoyama, S, Kuramitsu, S, Masui, R, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-05-25 | | Release date: | 2007-01-23 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of dNTP-inducible dNTP triphosphohydrolase: insight into broad specificity for dNTPs and triphosphohydrolase-type hydrolysis
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
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2E3V
 | | Crystal structure of the first fibronectin type III domain of neural cell adhesion molecule splicing isoform from human muscle culture lambda-4.4 | | Descriptor: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Nishino, A, Saijo, S, Kishishita, S, Chen, L, Liu, Z.J, Wang, B.C, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-11-30 | | Release date: | 2007-06-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of the first fibronectin type III domain of neural cell adhesion molecule splicing isoform from human muscle culture lambda-4.4
To be Published
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3G7N
 | | Crystal Structure of a Triacylglycerol Lipase from Penicillium Expansum at 1.3 | | Descriptor: | DI(HYDROXYETHYL)ETHER, Lipase, PENTAETHYLENE GLYCOL, ... | | Authors: | Bian, C.B, Yuan, C, Chen, L.Q, Edward, J.M, Lin, L, Jiang, L.G, Huang, Z.X, Huang, M.D. | | Deposit date: | 2009-02-10 | | Release date: | 2010-02-23 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Crystal structure of a triacylglycerol lipase from Penicillium expansum at 1.3 A determined by sulfur SAD
Proteins, 78, 2010
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1NLM
 | | CRYSTAL STRUCTURE OF MURG:GLCNAC COMPLEX | | Descriptor: | GLYCEROL, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | | Authors: | Hu, Y, Chen, L, Ha, S, Gross, B, Falcone, B, Walker, D, Mokhtarzadeh, M, Walker, S. | | Deposit date: | 2003-01-07 | | Release date: | 2003-02-11 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases
Proc.Natl.Acad.Sci.USA, 100, 2003
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8IA7
 | | Structural insights into human brain gut peptide cholecystokinin receptors | | Descriptor: | CCK-8, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S. | | Deposit date: | 2023-02-08 | | Release date: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into human brain-gut peptide cholecystokinin receptors.
Cell Discov, 8, 2022
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2H8N
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1OWR
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