5TVM
 
 | | Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer | | Descriptor: | 1,4-DIAMINOBUTANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-adenosylmethionine decarboxylase alpha chain, ... | | Authors: | Volkov, O.A, Chen, Z, Tomchick, D.R, Phillips, M.A. | | Deposit date: | 2016-11-09 | | Release date: | 2017-01-11 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.408 Å) | | Cite: | Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
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5TVF
 | | Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with inhibitor CGP 40215 | | Descriptor: | 1,4-DIAMINOBUTANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-[C-[N'-(3-CARBAMIMIDOYL-BENZYLIDENIUM)-HYDRAZINO]-[[AMINOMETHYLIDENE]AMINIUM]-IMINOMETHYL]-BENZAMIDINIUM, ... | | Authors: | Phillips, M.A, Volkov, O.A, Chen, Z, Tomchick, D.R. | | Deposit date: | 2016-11-08 | | Release date: | 2017-01-11 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
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5TVO
 | | Crystal structure of Trypanosoma brucei AdoMetDC-delta26 monomer | | Descriptor: | PYRUVIC ACID, S-adenosylmethionine decarboxylase proenzyme, SODIUM ION | | Authors: | Volkov, O.A, Ariagno, C, Chen, Z, Tomchick, D.R, Phillips, M.A. | | Deposit date: | 2016-11-09 | | Release date: | 2016-12-28 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.481 Å) | | Cite: | Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
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5T0L
 | | Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF and 5-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-15) | | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-[4-(3,4-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4-diamine, ... | | Authors: | Thomas, S.B, Chen, Z, Lu, H, Li, Y. | | Deposit date: | 2016-08-16 | | Release date: | 2016-09-28 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.13 Å) | | Cite: | Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design.
ACS Med Chem Lett, 7, 2016
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5TF2
 | | CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN | | Descriptor: | Prolactin regulatory element-binding protein, UNKNOWN ATOM OR ION | | Authors: | Walker, J.R, Zhang, Q, Dong, A, Wernimont, A, Li, Y, He, H, Tempel, W, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Chen, Z, Tong, Y, Structural Genomics Consortium (SGC) | | Deposit date: | 2016-09-23 | | Release date: | 2016-11-23 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN (CASP target)
To be published
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4ILE
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4NA4
 | | Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain with ADP-HPD | | Descriptor: | 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, IODIDE ION, Poly(ADP-ribose) glycohydrolase | | Authors: | Wang, Z, Cheng, Z, Xu, W. | | Deposit date: | 2013-10-21 | | Release date: | 2014-01-29 | | Last modified: | 2014-09-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.
Plos One, 9, 2014
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4N9Y
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4NA0
 | | Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain with ADPRibose | | Descriptor: | IODIDE ION, Poly(ADP-ribose) glycohydrolase, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | Authors: | Wang, Z, Cheng, Z, Xu, W. | | Deposit date: | 2013-10-21 | | Release date: | 2014-01-29 | | Last modified: | 2014-09-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.
Plos One, 9, 2014
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4NA5
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4NA6
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4N9Z
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3M6N
 | | Crystal structure of RpfF | | Descriptor: | RpfF protein | | Authors: | Lim, S.C, Cheng, Z, Qamra, R, Song, H. | | Deposit date: | 2010-03-16 | | Release date: | 2010-09-22 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis of the Sensor-Synthase Interaction in Autoinduction of the Quorum Sensing Signal DSF Biosynthesis
Structure, 18, 2010
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1FPR
 | | CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN THE CATALYTIC DOMAIN OF SHP-1 AND AN IN VITRO PEPTIDE SUBSTRATE PY469 DERIVED FROM SHPS-1. | | Descriptor: | PEPTIDE PY469, PROTEIN-TYROSINE PHOSPHATASE 1C | | Authors: | Yang, J, Cheng, Z, Niu, Z, Zhao, Z.J, Zhou, G.W. | | Deposit date: | 2000-08-31 | | Release date: | 2001-03-07 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 275, 2000
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3EIQ
 | | Crystal structure of Pdcd4-eIF4A | | Descriptor: | Eukaryotic initiation factor 4A-I, Programmed cell death protein 4 | | Authors: | Loh, P.G, Cheng, Z, Song, H. | | Deposit date: | 2008-09-17 | | Release date: | 2009-02-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural basis for translational inhibition by the tumour suppressor Pdcd4
Embo J., 28, 2009
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7DIY
 | | Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-exoribonuclease domain | | Descriptor: | MAGNESIUM ION, ZINC ION, nsp10 protein, ... | | Authors: | Lin, S, Chen, H, Chen, Z.M, Yang, F.L, Ye, F, Zheng, Y, Yang, J, Lin, X, Sun, H.L, Wang, L.L, Wen, A, Cao, Y, Lu, G.W. | | Deposit date: | 2020-11-19 | | Release date: | 2021-05-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.693 Å) | | Cite: | Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity.
Nucleic Acids Res., 49, 2021
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7D6C
 | | Crystal structure of CcmM N-terminal domain in complex with CcmN | | Descriptor: | Carbon dioxide concentrating mechanism protein CcmM, Carboxysome assembly protein CcmN | | Authors: | Sun, H, Cui, N, Han, S.J, Chen, Z.P, Xia, L.Y, Chen, Y, Jiang, Y.L, Zhou, C.Z. | | Deposit date: | 2020-09-30 | | Release date: | 2021-08-04 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.89 Å) | | Cite: | Complex structure reveals CcmM and CcmN form a heterotrimeric adaptor in beta-carboxysome.
Protein Sci., 30, 2021
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7FDV
 | | Cryo-EM structure of the human cholesterol transporter ABCG1 in complex with cholesterol | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family G member 1, CHOLESTEROL, ... | | Authors: | Xu, D, Li, Y.Y, Yang, F.R, Sun, C.R, Pan, J.H, Wang, L, Chen, Z.P, Fang, S.C, Yao, X.B, Hou, W.T, Zhou, C.Z, Chen, Y. | | Deposit date: | 2021-07-18 | | Release date: | 2022-06-22 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Structure and transport mechanism of the human cholesterol transporter ABCG1.
Cell Rep, 38, 2022
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7EE5
 | | Crystal structure of Neu5Gc bound PltC | | Descriptor: | N-glycolyl-alpha-neuraminic acid, N-glycolyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, Subtilase cytotoxin subunit B-like protein, ... | | Authors: | Liu, X.Y, Chen, Z, Gao, X. | | Deposit date: | 2021-03-17 | | Release date: | 2021-12-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.24 Å) | | Cite: | Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin.
Mbio, 13, 2022
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7EE4
 | | Crystal structure of Neu5Ac bound PltC | | Descriptor: | N-acetyl-alpha-neuraminic acid, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, ... | | Authors: | Liu, X.Y, Chen, Z, Gao, X. | | Deposit date: | 2021-03-17 | | Release date: | 2021-12-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin.
Mbio, 13, 2022
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7EE3
 | | Crystal structure of PltC | | Descriptor: | Subtilase cytotoxin subunit B-like protein, TETRAETHYLENE GLYCOL | | Authors: | Liu, X.Y, Chen, Z, Gao, X. | | Deposit date: | 2021-03-17 | | Release date: | 2021-12-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin.
Mbio, 13, 2022
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7DRB
 | | Crystal structure of plant receptor like protein RXEG1 with xyloglucanase XEG1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cell 12A endoglucanase, ... | | Authors: | Sun, Y, Wang, Y, Zhang, X.X, Chen, Z.D, Xia, Y.Q, Sun, Y.J, Zhang, M.M, Xiao, Y, Han, Z.F, Wang, Y.C, Chai, J.J. | | Deposit date: | 2020-12-27 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Plant receptor-like protein activation by a microbial glycoside hydrolase.
Nature, 610, 2022
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7DRC
 | | Cryo-EM structure of plant receptor like protein RXEG1 in complex with xyloglucanase XEG1 and BAK1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Brassinosteroid insensitive 1-associated receptor kinase 1, ... | | Authors: | Sun, Y, Wang, Y, Zhang, X.X, Chen, Z.D, Xia, Y.Q, Sun, Y.J, Zhang, M.M, Xiao, Y, Han, Z.F, Wang, Y.C, Chai, J.J. | | Deposit date: | 2020-12-27 | | Release date: | 2022-06-22 | | Last modified: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Plant receptor-like protein activation by a microbial glycoside hydrolase.
Nature, 610, 2022
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7EXM
 | | The N-terminal crystal structure of SARS-CoV-2 NSP2 | | Descriptor: | GLYCEROL, Non-structural protein 2, ZINC ION | | Authors: | Ma, J, Chen, Z. | | Deposit date: | 2021-05-27 | | Release date: | 2021-06-16 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Structure and Function of N-Terminal Zinc Finger Domain of SARS-CoV-2 NSP2.
Virol Sin, 36, 2021
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7EV8
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