2HWL
 
 | | Crystal structure of thrombin in complex with fibrinogen gamma' peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen gamma' peptide, Prothrombin, ... | | 著者 | Pineda, A.O, Chen, Z.W, Marino, F, Mathews, F.S, Mosesson, M.W, Di Cera, E. | | 登録日 | 2006-08-01 | | 公開日 | 2006-09-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of thrombin in complex with fibrinogen gamma' peptide.
Biophys.Chem., 125, 2007
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4XOI
 | | Structure of hsAnillin bound with RhoA(Q63L) at 2.1 Angstroms resolution | | 分子名称: | Actin-binding protein anillin, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Sun, L, Guan, R, Lee, I.-J, Liu, Y, Chen, M, Wang, J, Wu, J, Chen, Z. | | 登録日 | 2015-01-16 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | | 主引用文献 | Mechanistic insights into the anchorage of the contractile ring by anillin and mid1
Dev.Cell, 33, 2015
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7YD1
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5KF4
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4XXB
 | | Crystal structure of human MDM2-RPL11 | | 分子名称: | 60S ribosomal protein L11, BETA-MERCAPTOETHANOL, E3 ubiquitin-protein ligase Mdm2, ... | | 著者 | Zheng, J, Chen, Z. | | 登録日 | 2015-01-30 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation
Genes Dev., 29, 2015
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1T3X
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2IAA
 | | Crystal Structure of an Electron Transfer Complex Between Aromatic Amine Dephydrogenase and Azurin from Alcaligenes Faecalis (Form 2) | | 分子名称: | Aromatic Amine Dehydrogenase, Azurin, COPPER (II) ION | | 著者 | Sukumar, N, Chen, Z, Leys, D, Scrutton, N.S, Ferrati, D, Merli, A, Rossi, G.L, Bellamy, H.D, Chistoserdov, A, Davidson, V.L, Mathews, F.S. | | 登録日 | 2006-09-07 | | 公開日 | 2006-11-21 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal Structure of an Electron Transfer Complex between Aromatic Amine Dehydrogenase and Azurin from Alcaligenes faecalis.
Biochemistry, 45, 2006
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4FWJ
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5J0H
 | | De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity | | 分子名称: | Design construct 2L6HC3_13 | | 著者 | Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. | | 登録日 | 2016-03-28 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
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5Z2S
 | | Crystal structure of DUX4-HD2 domain | | 分子名称: | Double homeobox protein 4 | | 著者 | Dong, X, Zhang, W, Wu, H, Huang, J, Zhang, M, Wang, P, Zhang, H, Chen, Z, Chen, S, Meng, G. | | 登録日 | 2018-01-03 | | 公開日 | 2018-04-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural basis of DUX4/IGH-driven transactivation.
Leukemia, 32, 2018
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4FWF
 | | Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.1, Lysine-specific histone demethylase 1B, ... | | 著者 | Zhang, Q, Chen, Z. | | 登録日 | 2012-07-01 | | 公開日 | 2013-01-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b
Cell Res., 23, 2013
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5WRW
 | | Structure of human apo-SRP72 | | 分子名称: | SULFATE ION, Signal recognition particle subunit SRP72 | | 著者 | Gao, Y, Chen, Z. | | 登録日 | 2016-12-04 | | 公開日 | 2017-06-21 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
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5Z2T
 | | Crystal structure of DNA-bound DUX4-HD2 | | 分子名称: | 5'-D(*TP*TP*CP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*TP*T)-3', 5'-D(P*AP*AP*GP*AP*TP*TP*AP*GP*AP*TP*TP*AP*GP*T)-3', Double homeobox protein 4 | | 著者 | Dong, X, Zhang, W, Wu, H, Huang, J, Zhang, M, Wang, P, Zhang, H, Chen, Z, Chen, S, Meng, G. | | 登録日 | 2018-01-04 | | 公開日 | 2018-04-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.623 Å) | | 主引用文献 | Structural basis of DUX4/IGH-driven transactivation.
Leukemia, 32, 2018
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8I4F
 | | Omicron spike variant XBB with n3130v-Fc | | 分子名称: | Spike glycoprotein, n3130v-Fc | | 著者 | Hao, A.H, Zhang, X, Chen, Z.G, Sun, L. | | 登録日 | 2023-01-19 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants.
Signal Transduct Target Ther, 8, 2023
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5YUF
 | | Crystal Structure of PML RING tetramer | | 分子名称: | Protein PML, ZINC ION | | 著者 | Wang, P, Benhend, S, Wu, H, Breitenbach, V, Zhen, T, Jollivet, F, Peres, L, Li, Y, Chen, S, Chen, Z, de THE, H, Meng, G. | | 登録日 | 2017-11-22 | | 公開日 | 2018-04-11 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | RING tetramerization is required for nuclear body biogenesis and PML sumoylation.
Nat Commun, 9, 2018
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8I4G
 | | Omicron spike variant BQ.1.1 with n3130v-Fc | | 分子名称: | Spike glycoprotein, n3130v-Fc | | 著者 | Hao, A.H, Zhang, X, Chen, Z.G, Sun, L. | | 登録日 | 2023-01-19 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants.
Signal Transduct Target Ther, 8, 2023
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8I4E
 | | Omicron spike variant XBB with Bn03 | | 分子名称: | Bn03, Spike glycoprotein | | 著者 | Hao, A.H, Zhang, X, Chen, Z.G, Sun, L. | | 登録日 | 2023-01-19 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | | 主引用文献 | Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants.
Signal Transduct Target Ther, 8, 2023
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8I4H
 | | Omicron spike variant BA.1 with Bn03 | | 分子名称: | Bn03, Spike glycoprotein | | 著者 | Hao, A.H, Zhang, X, Chen, Z.G, Sun, L. | | 登録日 | 2023-01-19 | | 公開日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants.
Signal Transduct Target Ther, 8, 2023
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1TQF
 | | Crystal structure of human Beta secretase complexed with inhibitor | | 分子名称: | 3-{2-[(5-AMINOPENTYL)AMINO]-2-OXOETHOXY}-5-({[1-(4-FLUOROPHENYL)ETHYL]AMINO}CARBONYL)PHENYL PHENYLMETHANESULFONATE, Beta-secretase 1 | | 著者 | Munshi, S, Chen, Z, Kuo, L. | | 登録日 | 2004-06-17 | | 公開日 | 2004-11-09 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.
J.Med.Chem., 47, 2004
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6K15
 | | RSC substrate-recruitment module | | 分子名称: | Chromatin structure-remodeling complex protein RSC3, Chromatin structure-remodeling complex protein RSC30, Chromatin structure-remodeling complex protein RSC58, ... | | 著者 | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | | 登録日 | 2019-05-09 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of the RSC complex bound to the nucleosome.
Science, 366, 2019
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2AYP
 | | Crystal Structure of CHK1 with an Indol Inhibitor | | 分子名称: | (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE, Serine/threonine-protein kinase Chk1 | | 著者 | Lin, N.-H, Xia, P, Kovar, P, Chen, Z, Zhang, H, Rosenberg, S.H, Sham, H.L. | | 登録日 | 2005-09-07 | | 公開日 | 2006-09-12 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors
Bioorg.Med.Chem.Lett., 16, 2006
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7VW8
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7VW9
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2H3X
 | | Crystal Structure of an Electron Transfer Complex Between Aromatic Amine Dehydrogenase and Azurin from Alcaligenes Faecalis (Form 3) | | 分子名称: | Aromatic Amine Dehydrogenase, Azurin, COPPER (II) ION | | 著者 | Sukumar, N, Chen, Z, Leys, D, Scrutton, N.S, Ferrati, D, Merli, A, Rossi, G.L, Bellamy, H.D, Chistoserdov, A, Davidson, V.L, Mathews, F.S. | | 登録日 | 2006-05-23 | | 公開日 | 2006-11-21 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of an Electron Transfer Complex between Aromatic Amine Dehydrogenase and Azurin from Alcaligenes faecalis.
Biochemistry, 45, 2006
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1T32
 | | A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation | | 分子名称: | 2-[3-({METHYL[1-(2-NAPHTHOYL)PIPERIDIN-4-YL]AMINO}CARBONYL)-2-NAPHTHYL]-1-(1-NAPHTHYL)-2-OXOETHYLPHOSPHONIC ACID, Cathepsin G, SULFATE ION | | 著者 | de Garavilla, L, Greco, M.N, Giardino, E.C, Wells, G.I, Haertlein, B.J, Kauffman, J.A, Corcoran, T.W, Derian, C.K, Eckardt, A.J, Abraham, W.M, Sukumar, N, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E, Andrade-Gordon, P, Damiano, B.P, Maryanoff, B.E. | | 登録日 | 2004-04-23 | | 公開日 | 2005-03-01 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
J.Biol.Chem., 280, 2005
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