7MO9
 
 | | Cryo-EM map of the c-MET II/HGF I/HGF II (K4 and SPH) sub-complex | | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | | 登録日 | 2021-05-01 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
|
|
8PNM
 | | Structure of human KCTD15 BTB domain mutant G88D crystal form 2 | | 分子名称: | BTB/POZ domain-containing protein KCTD15 | | 著者 | Cruz Walma, D.A, Cros, J, Bradshaw, W, Richardson, W, Chen, Z, Chalk, R, Wilkie, A, Bullock, A.N. | | 登録日 | 2023-06-30 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome.
J Med Genet, 61, 2024
|
|
1NWO
 | |
4XXB
 | | Crystal structure of human MDM2-RPL11 | | 分子名称: | 60S ribosomal protein L11, BETA-MERCAPTOETHANOL, E3 ubiquitin-protein ligase Mdm2, ... | | 著者 | Zheng, J, Chen, Z. | | 登録日 | 2015-01-30 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation
Genes Dev., 29, 2015
|
|
3JZ2
 | | Crystal structure of human thrombin mutant N143P in E* form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Thrombin heavy chain, ... | | 著者 | Niu, W, Chen, Z, Bush-Pelc, L.A, Bah, A, Gandhi, P.S, Di Cera, E. | | 登録日 | 2009-09-22 | | 公開日 | 2009-10-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Mutant N143P reveals how Na+ activates thrombin
J.Biol.Chem., 284, 2009
|
|
5TF2
 | | CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN | | 分子名称: | Prolactin regulatory element-binding protein, UNKNOWN ATOM OR ION | | 著者 | Walker, J.R, Zhang, Q, Dong, A, Wernimont, A, Li, Y, He, H, Tempel, W, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Chen, Z, Tong, Y, Structural Genomics Consortium (SGC) | | 登録日 | 2016-09-23 | | 公開日 | 2016-11-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN (CASP target)
To be published
|
|
5TO3
 | | Crystal structure of thrombin mutant W215A/E217A fused to EGF456 of thrombomodulin via a 31-residue linker and bound to PPACK | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... | | 著者 | Barranco-Medina, S, Murphy, M, Pelc, L, Chen, Z, Di Cera, E, Pozzi, N. | | 登録日 | 2016-10-16 | | 公開日 | 2017-03-29 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Rational Design of Protein C Activators.
Sci Rep, 7, 2017
|
|
8DYO
 | | Cryo-EM structure of Importin-4 bound to RanGTP | | 分子名称: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ... | | 著者 | Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M. | | 登録日 | 2022-08-04 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | | 主引用文献 | Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7MOA
 | | Cryo-EM structure of the c-MET II/HGF I complex bound with HGF II in a rigid conformation | | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | | 登録日 | 2021-05-01 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
|
|
7MOB
 | | Cryo-EM structure of 2:2 c-MET/NK1 complex | | 分子名称: | Hepatocyte growth factor, Hepatocyte growth factor receptor | | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | | 登録日 | 2021-05-01 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (5 Å) | | 主引用文献 | Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
|
|
1L9C
 | | Role of Histidine 269 in Catalysis by Monomeric Sarcosine Oxidase | | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Monomeric Sarcosine Oxidase, ... | | 著者 | Zhao, G, Song, H, Chen, Z.-w, Mathews, F.S, Jorns, M.S. | | 登録日 | 2002-03-22 | | 公開日 | 2002-08-30 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Monomeric sarcosine oxidase: role of histidine 269 in catalysis.
Biochemistry, 41, 2002
|
|
5TVM
 | | Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer | | 分子名称: | 1,4-DIAMINOBUTANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-adenosylmethionine decarboxylase alpha chain, ... | | 著者 | Volkov, O.A, Chen, Z, Tomchick, D.R, Phillips, M.A. | | 登録日 | 2016-11-09 | | 公開日 | 2017-01-11 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.408 Å) | | 主引用文献 | Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
|
|
5TVO
 | | Crystal structure of Trypanosoma brucei AdoMetDC-delta26 monomer | | 分子名称: | S-adenosylmethionine decarboxylase alpha chain, S-adenosylmethionine decarboxylase proenzyme, SODIUM ION | | 著者 | Volkov, O.A, Ariagno, C, Chen, Z, Tomchick, D.R, Phillips, M.A. | | 登録日 | 2016-11-09 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.481 Å) | | 主引用文献 | Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
|
|
1NPA
 | | crystal structure of HIV-1 protease-hup | | 分子名称: | (3S)-TETRAHYDROFURAN-3-YL (1R,2S)-3-[4-((1R)-2-{[(S)-AMINO(HYDROXY)METHYL]OXY}-2,3-DIHYDRO-1H-INDEN-1-YL)-2-BENZYL-3-OXOPYRROLIDIN-2-YL]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, POL polyprotein | | 著者 | Smith III, A.B, Hirschmann, R, Pasternak, A, Yao, W, Sprengeler, P.A, Holloway, M.K, Kuo, L.C, Chen, Z, Darke, P.L, Schleif, W.A. | | 登録日 | 2003-01-17 | | 公開日 | 2004-01-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.
J.MED.CHEM., 40, 1997
|
|
1MG3
 | | MUTATION OF ALPHA PHE55 OF METHYLAMINE DEHYDROGENASE ALTERS THE REORGANIZATION ENERGY AND ELECTRONIC COUPLING FOR ITS ELECTRON TRANSFER REACTION WITH AMICYANIN | | 分子名称: | Amicyanin, COPPER (II) ION, CYTOCHROME C-L, ... | | 著者 | Sun, D, Chen, Z.W, Mathews, F.S, Davidson, V.L. | | 登録日 | 2002-08-14 | | 公開日 | 2002-12-11 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | MUTATION OF ALPHA PHE55 OF METHYLAMINE DEHYDROGENASE ALTERS THE REORGANIZATION ENERGY AND ELECTRONIC COUPLING FOR ITS ELECTRON TRANSFER REACTION WITH AMICYANIN
Biochemistry, 41, 2002
|
|
5BQX
 | | Crystal structure of human STING in complex with 3'2'-cGAMP | | 分子名称: | 3'2'-cGAMP, Stimulator of interferon genes protein | | 著者 | Wu, J, Zhang, X, Chen, Z.J, Chen, C. | | 登録日 | 2015-05-29 | | 公開日 | 2015-06-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
1JJU
 | | Structure of a Quinohemoprotein Amine Dehydrogenase with a Unique Redox Cofactor and Highly Unusual Crosslinking | | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, QUINOHEMOPROTEIN AMINE DEHYDROGENASE, SODIUM ION, ... | | 著者 | Datta, S, Mori, Y, Takagi, K, Kawaguchi, K, Chen, Z.-W, Kano, K, Ikeda, T, Okajima, T, Kuroda, S, Tanizawa, K, Mathews, F.S. | | 登録日 | 2001-07-09 | | 公開日 | 2001-12-12 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structure of a quinohemoprotein amine dehydrogenase with an uncommon redox cofactor and highly unusual crosslinking.
Proc.Natl.Acad.Sci.USA, 98, 2001
|
|
2BPY
 | | HIV-1 protease-inhibitor complex | | 分子名称: | HIV-1 PROTEASE, N-[2(S)-CYCLOPENTYL-1(R)-HYDROXY-3(R)METHYL]-5-[(2(S)-TERTIARY-BUTYLAMINO-CARBONYL)-4-(N1-(2)-(N-METHYLPIPERAZINYL)-3-CHLORO-PYRAZINYL-5-CARBONYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYL-PENTANAMIDE | | 著者 | Munshi, S, Chen, Z. | | 登録日 | 1998-01-22 | | 公開日 | 1999-02-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.
Acta Crystallogr.,Sect.D, 54, 1998
|
|
2BPZ
 | | HIV-1 protease-inhibitor complex | | 分子名称: | HIV-1 PROTEASE, N-[2(S)-CYCLOPENTYL-1(R)-HYDROXY-3(R)METHYL]-5-[(2(S)-TERTIARY-BUTYLAMINO-CARBONYL)-4-(N1-(2)-(N-METHYLPIPERAZINYL)-3-CHLORO-PYRAZINYL-5-CARBONYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYL-PENTANAMIDE | | 著者 | Munshi, S, Chen, Z. | | 登録日 | 1998-01-22 | | 公開日 | 1999-02-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.
Acta Crystallogr.,Sect.D, 54, 1998
|
|
2BPW
 | | HIV-1 protease-inhibitor complex | | 分子名称: | 1-[2-HYDROXY-4-(2-HYDROXY-5-METHYL-CYCLOPENTYLCARBAMOYL)5-PHENYL-PENTYL]-4-(3-PYRIDIN-3-YL-PROPIONYL)-PIPERAZINE-2-CARB OXYLIC ACID TERT-BUTYLAMIDE, HIV-1 PROTEASE | | 著者 | Munshi, S, Chen, Z. | | 登録日 | 1998-01-22 | | 公開日 | 1999-02-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.
Acta Crystallogr.,Sect.D, 54, 1998
|
|
2BPX
 | | HIV-1 protease-inhibitor complex | | 分子名称: | HIV-1 PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE | | 著者 | Munshi, S, Chen, Z. | | 登録日 | 1998-01-22 | | 公開日 | 1999-02-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.
Acta Crystallogr.,Sect.D, 54, 1998
|
|
1L9D
 | | Role of Histidine 269 in Catalysis by Monomeric Sarcosine Oxidase | | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Monomeric sarcosine oxidase, ... | | 著者 | Zhao, G, Song, H, Chen, Z.-w, Mathews, F.S, Jorns, M.S. | | 登録日 | 2002-03-22 | | 公開日 | 2002-08-30 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Monomeric sarcosine oxidase: role of histidine 269 in catalysis.
Biochemistry, 41, 2002
|
|
6PXJ
 | | Crystal structure of human thrombin mutant I16T | | 分子名称: | GLYCEROL, MAGNESIUM ION, Thrombin heavy chain, ... | | 著者 | Stojanovski, B, Chen, Z, Koester, S.K, Pelc, L.A, Di Cera, E. | | 登録日 | 2019-07-26 | | 公開日 | 2019-12-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Role of the I16-D194 ionic interaction in the trypsin fold.
Sci Rep, 9, 2019
|
|
6IY3
 | | Structure of Snf2-MMTV-A nucleosome complex at shl-2 in ADP state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (147-MER), Histone H2A, ... | | 著者 | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | | 登録日 | 2018-12-12 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | | 主引用文献 | Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
|
|
3QQ4
 | | Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides | | 分子名称: | Beta-2-microglobulin, MHC class I antigen, VP35 | | 著者 | Zhang, N, Qi, J, Gao, F, Pan, X, Chen, R, Li, Q, Chen, Z, Li, X, Xia, C, Gao, G.F. | | 登録日 | 2011-02-15 | | 公開日 | 2011-12-28 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.097 Å) | | 主引用文献 | Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides.
J.Virol., 85, 2011
|
|
