1NPA

crystal structure of HIV-1 protease-hup

Summary for 1NPA

Entry DOI	10.2210/pdb1npa/pdb
Descriptor	POL polyprotein, (3S)-TETRAHYDROFURAN-3-YL (1R,2S)-3-[4-((1R)-2-{[(S)-AMINO(HYDROXY)METHYL]OXY}-2,3-DIHYDRO-1H-INDEN-1-YL)-2-BENZYL-3-OXOPYRROLIDIN-2-YL]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
Functional Keywords	protease, hiv, aspartyl protease, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22237.25
Authors	Smith III, A.B.,Hirschmann, R.,Pasternak, A.,Yao, W.,Sprengeler, P.A.,Holloway, M.K.,Kuo, L.C.,Chen, Z.,Darke, P.L.,Schleif, W.A. (deposition date: 2003-01-17, release date: 2004-01-27, Last modification date: 2024-02-14)
Primary citation	Smith III, A.B.,Hirschmann, R.,Pasternak, A.,Yao, W.,Sprengeler, P.A.,Holloway, M.K.,Kuo, L.C.,Chen, Z.,Darke, P.L.,Schleif, W.A. An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex. J.MED.CHEM., 40:2440-2444, 1997 Cited by PubMed: 9258349 DOI: 10.1021/jm970195u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation