8TQC
 
 | | Structure of the human CDK8 kinase module | | Descriptor: | Cyclin-C, Cyclin-dependent kinase 8, Mediator of RNA polymerase II transcription subunit 12, ... | | Authors: | Chen, S.F, Chao, T.C, Kim, H.J, Tang, H.C, Khadka, S, Li, T, Murakami, K, Boyer, T.G, Tsai, K.L. | | Deposit date: | 2023-08-06 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module.
Mol.Cell, 2024
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8TRH
 | | The IDRc bound human core Mediator complex | | Descriptor: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | | Authors: | Chen, S.F, Chao, T.C, Kim, H.J, Tang, H.C, Khadka, S, Li, T, Murakami, K, Boyer, T.G, Tsai, K.L. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module.
Mol.Cell, 2024
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8TQW
 | | Structure of human transcriptional Mediator complex | | Descriptor: | Cyclin-C, Cyclin-dependent kinase 8, Mediator of RNA polymerase II transcription subunit 1, ... | | Authors: | Chen, S.F, Chao, T.C, Kim, H.J, Tang, H.C, Khadka, S, Li, T, Murakami, K, Boyer, T.G, Tsai, K.L. | | Deposit date: | 2023-08-08 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (8.2 Å) | | Cite: | Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module.
Mol.Cell, 2024
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7DRY
 | | Crystal structure of Aspergillus oryzae Rib2 deaminase | | Descriptor: | CMP/dCMP-type deaminase domain-containing protein, SULFATE ION, ZINC ION | | Authors: | Chen, S.C, Liaw, S.H, Hsu, C.H. | | Deposit date: | 2020-12-30 | | Release date: | 2021-07-14 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.44 Å) | | Cite: | Crystal structures of Aspergillus oryzae Rib2 deaminase: the functional mechanism involved in riboflavin biosynthesis.
Iucrj, 8, 2021
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6J21
 | | Crystal structure of the human NK1 substance P receptor | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, Substance-P receptor,Endolysin | | Authors: | Chen, S, Lu, M, Zhang, H, Wu, B, Zhao, Q. | | Deposit date: | 2018-12-30 | | Release date: | 2019-03-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
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1ONO
 | | IspC Mn2+ complex | | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, MANGANESE (II) ION | | Authors: | Steinbacher, S, Kaiser, J, Eisenreich, W, Huber, R, Bacher, A, Rohdich, F. | | Deposit date: | 2003-02-28 | | Release date: | 2003-03-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol
4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria
drug development.
J.BIOL.CHEM., 278, 2003
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7EDP
 | | Crystal structure of AF10-DOT1L complex | | Descriptor: | Histone-lysine N-methyltransferase, H3 lysine-79 specific, Protein AF-10 | | Authors: | Chen, S, Zhou, Z. | | Deposit date: | 2021-03-16 | | Release date: | 2021-04-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural characteristics of coiled-coil regions in AF10-DOT1L and AF10-inhibitory peptide complex.
J Leukoc Biol, 110, 2021
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7EKN
 | | Crystal structure of AF10-ipep complex | | Descriptor: | Protein AF-10, ipep | | Authors: | Chen, S, Zhou, Z. | | Deposit date: | 2021-04-05 | | Release date: | 2021-04-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Structural characteristics of coiled-coil regions in AF10-DOT1L and AF10-inhibitory peptide complex.
J Leukoc Biol, 110, 2021
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5ZEN
 | | Crystal structure of human topoisomerase II beta in complex with DNA: a new quaternary conformation showing opening of the protein-linked DNA-gate | | Descriptor: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... | | Authors: | Chen, S.F, Wang, Y.R, Chan, N.L. | | Deposit date: | 2018-02-27 | | Release date: | 2018-08-08 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
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5ZQF
 | | Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA in space group P3221 | | Descriptor: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA topoisomerase 2-beta, DNA/RNA (5'-D(P*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ... | | Authors: | Chen, S.F, Wang, Y.R, Chan, N.L. | | Deposit date: | 2018-04-18 | | Release date: | 2018-08-08 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.873 Å) | | Cite: | Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
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7DHY
 | | Arsenic-bound p53 DNA-binding domain mutant G245S | | Descriptor: | ARSENIC, Cellular tumor antigen p53, GLYCEROL, ... | | Authors: | Chen, S, Lu, M. | | Deposit date: | 2020-11-18 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Cancer Cell, 39, 2021
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4EDJ
 | | Crystal structure of the GRASP55 GRASP Domain with a phosphomimetic mutation (S189D) | | Descriptor: | Golgi reassembly-stacking protein 2, POTASSIUM ION | | Authors: | Truschel, S.T, Zhang, M, Bachert, C, Macbeth, M.R, Linstedt, A.D. | | Deposit date: | 2012-03-27 | | Release date: | 2012-05-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Allosteric Regulation of GRASP Protein-dependent Golgi Membrane Tethering by Mitotic Phosphorylation.
J.Biol.Chem., 287, 2012
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7URL
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1XNL
 | | ASLV fusion peptide | | Descriptor: | membrane protein gp37 | | Authors: | Cheng, S.F, Wu, C.W, Kantchev, E.A, Chang, D.K. | | Deposit date: | 2004-10-05 | | Release date: | 2005-01-11 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Structure and membrane interaction of the internal fusion peptide of avian sarcoma leukosis virus
Eur.J.Biochem., 271, 2004
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1ONN
 | | IspC apo structure | | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | | Authors: | Steinbacher, S, Kaiser, J, Eisenreich, W, Huber, R, Bacher, A, Rohdich, F. | | Deposit date: | 2003-02-28 | | Release date: | 2003-03-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol
4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria
drug development.
J.BIOL.CHEM., 278, 2003
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7FCR
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7FCS
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5ZRF
 | | Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21 | | Descriptor: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA topoisomerase 2-beta, ... | | Authors: | Chen, S.F, Wang, Y.R, Wu, C.C, Chan, N.L. | | Deposit date: | 2018-04-24 | | Release date: | 2018-08-08 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
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2PEN
 | | Crystal structure of RbcX, crystal form I | | Descriptor: | ORF134 | | Authors: | Saschenbrecker, S, Bracher, A, Vasudeva Rao, K, Vasudeva Rao, B, Hartl, F.U, Hayer-Hartl, M. | | Deposit date: | 2007-04-03 | | Release date: | 2007-07-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure and Function of RbcX, an Assembly Chaperone for Hexadecameric Rubisco.
Cell(Cambridge,Mass.), 129, 2007
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1ONP
 | | IspC complex with Mn2+ and fosmidomycin | | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, MANGANESE (II) ION | | Authors: | Steinbacher, S, Kaiser, J, Eisenreich, W, Huber, R, Bacher, A, Rohdich, F. | | Deposit date: | 2003-02-28 | | Release date: | 2003-03-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol
4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria
drug development.
J.BIOL.CHEM., 278, 2003
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2PEJ
 | | Crystal structure of RbcX point mutant Y17A/Y20L | | Descriptor: | ORF134 | | Authors: | Saschenbrecker, S, Bracher, A, Vasudeva Rao, K, Vasudeva Rao, B, Hartl, F.U, Hayer-Hartl, M. | | Deposit date: | 2007-04-03 | | Release date: | 2007-07-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structure and Function of RbcX, an Assembly Chaperone for Hexadecameric Rubisco.
Cell(Cambridge,Mass.), 129, 2007
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2PEO
 | | Crystal structure of RbcX from Anabaena CA | | Descriptor: | RbcX protein | | Authors: | Saschenbrecker, S, Bracher, A, Vasudeva Rao, K, Vasudeva Rao, B, Hartl, F.U, Hayer-Hartl, M. | | Deposit date: | 2007-04-03 | | Release date: | 2007-07-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure and Function of RbcX, an Assembly Chaperone for Hexadecameric Rubisco.
Cell(Cambridge,Mass.), 129, 2007
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6LCJ
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2PEK
 | | Crystal structure of RbcX point mutant Q29A | | Descriptor: | ORF134 | | Authors: | Saschenbrecker, S, Bracher, A, Vasudeva Rao, K, Vasudeva Rao, B, Hartl, F.U, Hayer-Hartl, M. | | Deposit date: | 2007-04-03 | | Release date: | 2007-07-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure and Function of RbcX, an Assembly Chaperone for Hexadecameric Rubisco.
Cell(Cambridge,Mass.), 129, 2007
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2PEQ
 | | Crystal structure of RbcX, crystal form II | | Descriptor: | ORF134 | | Authors: | Saschenbrecker, S, Bracher, A, Vasudeva Rao, K, Vasudeva Rao, B, Hartl, F.U, Hayer-Hartl, M. | | Deposit date: | 2007-04-03 | | Release date: | 2007-07-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure and Function of RbcX, an Assembly Chaperone for Hexadecameric Rubisco.
Cell(Cambridge,Mass.), 129, 2007
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