6J21
Crystal structure of the human NK1 substance P receptor
Summary for 6J21
Entry DOI | 10.2210/pdb6j21/pdb |
Descriptor | Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate (3 entities in total) |
Functional Keywords | gpcr, complex, antagonist, signalling protein, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 51319.75 |
Authors | |
Primary citation | Chen, S.,Lu, M.,Liu, D.,Yang, L.,Yi, C.,Ma, L.,Zhang, H.,Liu, Q.,Frimurer, T.M.,Wang, M.W.,Schwartz, T.W.,Stevens, R.C.,Wu, B.,Wuthrich, K.,Zhao, Q. Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography. Nat Commun, 10:638-638, 2019 Cited by PubMed: 30733446DOI: 10.1038/s41467-019-08568-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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