1ONP
IspC complex with Mn2+ and fosmidomycin
Summary for 1ONP
Entry DOI | 10.2210/pdb1onp/pdb |
Related | 1ONN 1ONO |
Descriptor | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, MANGANESE (II) ION, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, ... (4 entities in total) |
Functional Keywords | isoprenoid biosynthesis, mevalonate-independent pathway, ispc, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 87339.83 |
Authors | Steinbacher, S.,Kaiser, J.,Eisenreich, W.,Huber, R.,Bacher, A.,Rohdich, F. (deposition date: 2003-02-28, release date: 2003-03-18, Last modification date: 2023-10-25) |
Primary citation | Steinbacher, S.,Kaiser, J.,Eisenreich, W.,Huber, R.,Bacher, A.,Rohdich, F. Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. J.BIOL.CHEM., 278:18401-18407, 2003 Cited by PubMed: 12621040DOI: 10.1074/jbc.M300993200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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