8HIT
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![BU of 8hit by Molmil](/molmil-images/mine/8hit) | Crystal structure of anti-CTLA-4 humanized IgG1 MAb--JS007 in complex with human CTLA-4 | Descriptor: | Cytotoxic T-lymphocyte protein 4, JS007-VH, JS007-VL | Authors: | Tan, S, Shi, Y, Wang, Q, Gao, G.F, Guan, J, Chai, Y, Qi, J. | Deposit date: | 2022-11-21 | Release date: | 2023-02-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer. Mabs, 15, 2023
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8KA8
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![BU of 8ka8 by Molmil](/molmil-images/mine/8ka8) | Cryo-EM structure of SARS-CoV-2 Delta RBD in complex with golden hamster ACE2 (local refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | Authors: | Niu, S, Zhao, Z.N, Chai, Y, Gao, G.F. | Deposit date: | 2023-08-02 | Release date: | 2024-01-31 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Structural basis and analysis of hamster ACE2 binding to different SARS-CoV-2 spike RBDs. J.Virol., 98, 2024
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8KC2
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![BU of 8kc2 by Molmil](/molmil-images/mine/8kc2) | Cryo-EM structure of SARS-CoV-2 BA.3 RBD in complex with golden hamster ACE2 (local refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | Authors: | Niu, S, Zhao, Z.N, Chai, Y, Gao, G.F. | Deposit date: | 2023-08-05 | Release date: | 2024-01-31 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis and analysis of hamster ACE2 binding to different SARS-CoV-2 spike RBDs. J.Virol., 98, 2024
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8GVB
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![BU of 8gvb by Molmil](/molmil-images/mine/8gvb) | The complex between public TCR TD08 and HLA-A24 bound to HIV-1 Nef138-8 peptide | Descriptor: | 8-mer peptide from Protein Nef, Beta-2-microglobulin, MHC class I antigen, ... | Authors: | Gao, G.F, Shi, Y, Ma, K, Chai, Y, Guan, J, Qi, J, Tan, S, Dong, T, Iwamoto, A, Kawana-Tachikawa, A. | Deposit date: | 2022-09-14 | Release date: | 2022-10-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Molecular Basis for the Recognition of HIV Nef138-8 Epitope by a Pair of Human Public T Cell Receptors. J Immunol., 209, 2022
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8GVG
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![BU of 8gvg by Molmil](/molmil-images/mine/8gvg) | The complex between public TCR TD08 and HLA-A24 bound to HIV-1 Nef138-8 (2F) peptide | Descriptor: | Beta-2-microglobulin, MHC class I antigen, TD08 TCR alpha chain, ... | Authors: | Gao, G.F, Shi, Y, Ma, K, Chai, Y, Guan, J, Qi, J, Tan, S, Dong, T, Iwamoto, A, Kawana-Tachikawa, A. | Deposit date: | 2022-09-15 | Release date: | 2022-10-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.37 Å) | Cite: | Molecular Basis for the Recognition of HIV Nef138-8 Epitope by a Pair of Human Public T Cell Receptors. J Immunol., 209, 2022
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8GVI
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![BU of 8gvi by Molmil](/molmil-images/mine/8gvi) | The complex between H25-11 TCR and HLA-A24 bound to HIV-1 Nef138-8 peptide | Descriptor: | 8-mer peptide from Protein Nef, Beta-2-microglobulin, H25-11 TCR alpha chain, ... | Authors: | Gao, G.F, Shi, Y, Tan, S, Ma, K, Chai, Y, Qi, J, Kawana-Tachikawa, A, Iwamoto, A, Dong, T, Guan, J. | Deposit date: | 2022-09-15 | Release date: | 2022-10-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Molecular Basis for the Recognition of HIV Nef138-8 Epitope by a Pair of Human Public T Cell Receptors. J Immunol., 209, 2022
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6J29
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![BU of 6j29 by Molmil](/molmil-images/mine/6j29) | The structure of HLA-A*3003/MTB | Descriptor: | Beta-2-microglobulin, HLA-A*3003, MTB | Authors: | Zhu, S.Y, Liu, K.F, Chai, Y, Ding, C.M, Lv, J.X, Gao, F.G, Lou, Y.L, Liu, W.J. | Deposit date: | 2018-12-31 | Release date: | 2019-09-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides. Front Immunol, 10, 2019
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5Y10
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![BU of 5y10 by Molmil](/molmil-images/mine/5y10) | SFTSV Gn head domain | Descriptor: | Membrane glycoprotein polyprotein, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Wu, Y, Gao, F, Qi, J.X, Chai, Y, Gao, G.F. | Deposit date: | 2017-07-19 | Release date: | 2017-09-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5Y0Y
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![BU of 5y0y by Molmil](/molmil-images/mine/5y0y) | RVFV GN-AU | Descriptor: | GOLD ION, NSmGnGc | Authors: | Wu, Y, Gao, F, Qi, J.X, Chai, Y, Gao, G.F. | Deposit date: | 2017-07-19 | Release date: | 2017-09-13 | Last modified: | 2017-09-20 | Method: | X-RAY DIFFRACTION (3.398 Å) | Cite: | Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5Y11
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![BU of 5y11 by Molmil](/molmil-images/mine/5y11) | SFTSV GN with neutralizing antibody MAb4-5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAb 4-5 heavy chain, MAb 4-5 light chain, ... | Authors: | Wu, Y, Gao, F, Qi, J.X, Chai, Y, Gao, G.F. | Deposit date: | 2017-07-19 | Release date: | 2017-09-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5Y0W
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![BU of 5y0w by Molmil](/molmil-images/mine/5y0w) | The structure of RVFV Gn head domain | Descriptor: | NSmGnGc | Authors: | Wu, Y, Gao, F, Qi, J.X, Chai, Y, Gao, G.F. | Deposit date: | 2017-07-19 | Release date: | 2017-09-13 | Last modified: | 2017-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6J1V
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![BU of 6j1v by Molmil](/molmil-images/mine/6j1v) | The structure of HLA-A*3003/RT313 | Descriptor: | Beta-2-microglobulin, HLA-A*3003, RT313 | Authors: | Zhu, S.Y, Liu, K.F, Chai, Y, Ding, C.M, Lv, J.X, Gao, G.F, Lou, Y.L, Liu, W.J. | Deposit date: | 2018-12-29 | Release date: | 2019-09-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides. Front Immunol, 10, 2019
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6K7O
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![BU of 6k7o by Molmil](/molmil-images/mine/6k7o) | Complex structure of LILRB4 and h128-3 antibody | Descriptor: | Leukocyte immunoglobulin-like receptor subfamily B member 4, h128-3 Fab heavy chain, h128-3 Fab light chain | Authors: | Song, H, Chai, Y, Xu, X, Gao, F.G. | Deposit date: | 2019-06-08 | Release date: | 2019-07-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.004 Å) | Cite: | Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development. Cancer Immunol Res, 7, 2019
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6J2A
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![BU of 6j2a by Molmil](/molmil-images/mine/6j2a) | The structure of HLA-A*3003/NP44 | Descriptor: | Beta-2-microglobulin, HLA-A*3003, NP44 | Authors: | Zhu, S.Y, Liu, K.F, Chai, Y, Ding, C.M, Lv, J.X, Gao, F.G, Lou, Y.L, Liu, W.J. | Deposit date: | 2018-12-31 | Release date: | 2019-09-25 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides. Front Immunol, 10, 2019
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6J1W
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![BU of 6j1w by Molmil](/molmil-images/mine/6j1w) | The structure of HLA-A*3001/RT313 | Descriptor: | ALA-ILE-PHE-GLN-SER-SER-MET-THR-LYS, Beta-2-microglobulin, HLA-A*3001 | Authors: | Zhu, S.Y, Liu, K.F, Chai, Y, Ding, C.M, Lv, J.X, Gao, G.F, Lou, Y.L, Liu, W.J. | Deposit date: | 2018-12-29 | Release date: | 2019-09-25 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides. Front Immunol, 10, 2019
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5WXC
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![BU of 5wxc by Molmil](/molmil-images/mine/5wxc) | Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 2) | Descriptor: | Beta-2-microglobulin, H7-25-F, HLA class I histocompatibility antigen, ... | Authors: | Zhao, M, Liu, K, Chai, Y, Qi, J, Liu, J, Gao, G.F. | Deposit date: | 2017-01-07 | Release date: | 2018-01-17 | Last modified: | 2019-07-31 | Method: | X-RAY DIFFRACTION (2.295 Å) | Cite: | Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses. Mbio, 9, 2018
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5WWU
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![BU of 5wwu by Molmil](/molmil-images/mine/5wwu) | Crystal Structure of HLA-A*2402 in complex with 2009 pandemic influenza A(H1N1) virus and avian influenza A(H5N1) virus-derived peptide H1-25 | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... | Authors: | Zhao, M, Liu, K, Chai, Y, Qi, J, Liu, J, Gao, G.F. | Deposit date: | 2017-01-05 | Release date: | 2018-01-17 | Last modified: | 2019-07-31 | Method: | X-RAY DIFFRACTION (2.794 Å) | Cite: | Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses. Mbio, 9, 2018
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6A3V
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![BU of 6a3v by Molmil](/molmil-images/mine/6a3v) | Complex structure of human 4-1BB and 4-1BBL | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 | Authors: | Li, Y, Zhang, C, Chai, Y, Qi, J, Tien, P, Gao, S, Gao, G.F. | Deposit date: | 2018-06-17 | Release date: | 2018-10-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.391 Å) | Cite: | Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab. Cell Rep, 25, 2018
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5WXD
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![BU of 5wxd by Molmil](/molmil-images/mine/5wxd) | Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1) | Descriptor: | Beta-2-microglobulin, H7-25, HLA class I histocompatibility antigen, ... | Authors: | Zhao, M, Liu, K, Chai, Y, Qi, J, Liu, J, Gao, G.F. | Deposit date: | 2017-01-07 | Release date: | 2018-01-17 | Last modified: | 2019-07-31 | Method: | X-RAY DIFFRACTION (3.295 Å) | Cite: | Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses. Mbio, 9, 2018
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6A3W
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![BU of 6a3w by Molmil](/molmil-images/mine/6a3w) | Complex structure of 4-1BB and utomilumab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor receptor superfamily member 9, utomilumab VH, ... | Authors: | Li, Y, Tan, S, Zhang, C, Chai, Y, Qi, J, Tien, P, Gao, S, Gao, G.F. | Deposit date: | 2018-06-17 | Release date: | 2018-10-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab. Cell Rep, 25, 2018
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5YOW
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![BU of 5yow by Molmil](/molmil-images/mine/5yow) | The post-fusion structure of the Heartland virus Gc glycoprotein | Descriptor: | Glycoprotein polyprotein, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Wu, Y, Gao, F, Qi, J.X, Chai, Y. | Deposit date: | 2017-10-31 | Release date: | 2017-11-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Postfusion Structure of the Heartland Virus Gc Glycoprotein Supports Taxonomic Separation of the Bunyaviral Families Phenuiviridae and Hantaviridae. J. Virol., 92, 2018
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6KY8
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![BU of 6ky8 by Molmil](/molmil-images/mine/6ky8) | Crystal structure of ASFV dUTPase | Descriptor: | E165R | Authors: | Li, C, Chai, Y, Song, H, Qi, J, Sun, Y, Gao, G.F. | Deposit date: | 2019-09-17 | Release date: | 2019-11-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target. Mbio, 10, 2019
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5WT9
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![BU of 5wt9 by Molmil](/molmil-images/mine/5wt9) | Complex structure of PD-1 and nivolumab-Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Nivolumab, Light Chain of Nivolumab, ... | Authors: | Tan, S, Zhang, H, Chai, Y, Song, H, Tong, Z, Wang, Q, Qi, J, Wong, G, Zhu, X, Liu, W.J, Gao, S, Wang, Z, Shi, Y, Yang, F, Gao, G.F, Yan, J. | Deposit date: | 2016-12-10 | Release date: | 2017-02-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | An unexpected N-terminal loop in PD-1 dominates binding by nivolumab. Nat Commun, 8, 2017
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6JBT
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![BU of 6jbt by Molmil](/molmil-images/mine/6jbt) | Complex structure of toripalimab-Fab and PD-1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain, ... | Authors: | Guo, L, Tan, S, Chai, Y, Qi, J, Gao, G.F, Yan, J. | Deposit date: | 2019-01-26 | Release date: | 2019-06-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy. Mabs, 11, 2019
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5YMV
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![BU of 5ymv by Molmil](/molmil-images/mine/5ymv) | Crystal structure of 9-mer peptide from influenza virus in complex with BF2*1201 | Descriptor: | ALA-VAL-LYS-GLY-VAL-GLY-THR-MET-VAL, Beta-2-microglobulin, Class I histocompatibility antigen, ... | Authors: | Xiao, J, Xiang, W, Qi, J, Chai, Y, Liu, W.J, Gao, G.F. | Deposit date: | 2017-10-22 | Release date: | 2018-10-24 | Last modified: | 2019-07-31 | Method: | X-RAY DIFFRACTION (2.197 Å) | Cite: | An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I. J Immunol., 201, 2018
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