6K7O

Complex structure of LILRB4 and h128-3 antibody

Summary for 6K7O

• Entry DOI: 10.2210/pdb6k7o/pdb
• Descriptor: Leukocyte immunoglobulin-like receptor subfamily B member 4, h128-3 Fab heavy chain, h128-3 Fab light chain (3 entities in total)
• Functional Keywords: lilrb4, antibody, immune therapy., immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 235461.63

Authors

Song, H.,Chai, Y.,Xu, X.,Gao, F.G. (deposition date: 2019-06-08, release date: 2019-07-03, Last modification date: 2023-11-22)

• Primary citation: Gui, X.,Deng, M.,Song, H.,Chen, Y.,Xie, J.,Li, Z.,He, L.,Huang, F.,Xu, Y.,Anami, Y.,Yu, H.,Yu, C.,Li, L.,Yuan, Z.,Xu, X.,Wang, Q.,Chai, Y.,Huang, T.,Shi, Y.,Tsuchikama, K.,Liao, X.C.,Xia, N.,Gao, G.F.,Zhang, N.,Zhang, C.C.,An, Z.; Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development.; Cancer Immunol Res, 7:1244-1257, 2019; PubMed: 31213474; DOI: 10.1158/2326-6066.CIR-19-0036

Experimental method

X-RAY DIFFRACTION (3.004 Å)