6KWS
 
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6KWT
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6KHE
 | | Crystal structure of CLK2 in complex with CX-4945 | | Descriptor: | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, Dual specificity protein kinase CLK2 | | Authors: | Lee, J.Y, Yun, J.S, Jin, H, Chang, J.H. | | Deposit date: | 2019-07-15 | | Release date: | 2019-10-02 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945.
Biomed Res Int, 2019, 2019
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6KHF
 | | Crystal structure of CLK3 in complex with CX-4945 | | Descriptor: | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, Dual specificity protein kinase CLK3 | | Authors: | Lee, J.Y, Yun, J.S, Jin, H, Chang, J.H. | | Deposit date: | 2019-07-15 | | Release date: | 2019-10-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.598 Å) | | Cite: | Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945.
Biomed Res Int, 2019, 2019
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6TGC
 | | CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex. | | Descriptor: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | | Authors: | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | | Deposit date: | 2019-11-15 | | Release date: | 2020-07-29 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Nat Commun, 11, 2020
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5BY2
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5XR4
 | | Crystal structure of RabA1a in complex with GDP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein RABA1a, ... | | Authors: | Yun, J.S, Chang, J.H. | | Deposit date: | 2017-06-07 | | Release date: | 2018-06-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure and subcellular localization of RabA1a from Arabidopsis thaliana
To Be Published
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5XR7
 | | Crystal structure of RabA1a (Q72K) in complex with GTP | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein RABA1a | | Authors: | Yun, J.S, Chang, J.H. | | Deposit date: | 2017-06-07 | | Release date: | 2018-06-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure and subcellular localization of RabA1a from Arabidopsis thaliana
To Be Published
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5XR6
 | | Crystal structure of RabA1a in complex with GppNHp | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein RABA1a | | Authors: | Yun, J.S, Chang, J.H. | | Deposit date: | 2017-06-07 | | Release date: | 2018-06-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure and subcellular localization of RabA1a from Arabidopsis thaliana
To Be Published
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3PQ1
 | | Crystal structure of human mitochondrial poly(A) polymerase (PAPD1) | | Descriptor: | Poly(A) RNA polymerase | | Authors: | Bai, Y, Srivastava, S.K, Chang, J.H, Tong, L. | | Deposit date: | 2010-11-25 | | Release date: | 2011-03-30 | | Last modified: | 2017-08-02 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase.
Mol.Cell, 41, 2011
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4PZC
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4PZE
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4PZD
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7BU2
 | | Structure of alcohol dehydrogenase YjgB from Escherichia coli | | Descriptor: | Alcohol dehydrogenase, GLYCEROL, NITRATE ION, ... | | Authors: | Nguyen, G.T, Kim, Y.-G, Ahn, J.-W, Chang, J.H. | | Deposit date: | 2020-04-03 | | Release date: | 2020-05-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.553 Å) | | Cite: | Structural Basis for Broad Substrate Selectivity of Alcohol Dehydrogenase YjgB from Escherichia coli .
Molecules, 25, 2020
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7BU3
 | | Structure of alcohol dehydrogenase YjgB in complex with NADP from Escherichia coli | | Descriptor: | ASPARTIC ACID, Alcohol dehydrogenase, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Nguyen, G.T, Kim, Y.-G, Ahn, J.-W, Chang, J.H. | | Deposit date: | 2020-04-03 | | Release date: | 2020-05-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis for Broad Substrate Selectivity of Alcohol Dehydrogenase YjgB from Escherichia coli .
Molecules, 25, 2020
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6IQ1
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4J7N
 | | Crystal structure of mouse DXO in complex with M7GPPPG cap | | Descriptor: | 1,2-ETHANEDIOL, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, 9-METHYLGUANINE, ... | | Authors: | Kilic, T, Chang, J.H, Tong, L. | | Deposit date: | 2013-02-13 | | Release date: | 2013-03-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.
Mol.Cell, 50, 2013
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5IM0
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2OPQ
 | | Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. | | Descriptor: | ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ... | | Authors: | Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K. | | Deposit date: | 2007-01-30 | | Release date: | 2007-05-22 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
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2OPR
 | | Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. | | Descriptor: | ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, Reverse transcriptase/ribonuclease H, p51 RT | | Authors: | Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K. | | Deposit date: | 2007-01-30 | | Release date: | 2007-05-22 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
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2OPS
 | | Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. | | Descriptor: | ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ... | | Authors: | Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K. | | Deposit date: | 2007-01-30 | | Release date: | 2007-05-22 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
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2OPP
 | | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X. | | Descriptor: | ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Chan, S.J.H, Kleim, J, Stammers, D.K. | | Deposit date: | 2007-01-30 | | Release date: | 2007-05-22 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
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1I53
 | | RE(I)-TRICARBONYL DIIMINE (Q107H)) AZURIN | | Descriptor: | 4,7-DIMETHYL-[1,10]PHENANTHROLINE, AZURIN, COPPER (II) ION, ... | | Authors: | Di Bilio, A.J, Crane, B.R, Wehbi, W.A, Kiser, C.N, Abu-Omar, M.M, Carlos, R.M, Richards, J.H, Winkler, J.R, Gray, H.B. | | Deposit date: | 2001-02-24 | | Release date: | 2001-10-17 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Properties of photogenerated tryptophan and tyrosyl radicals in structurally characterized proteins containing rhenium(I) tricarbonyl diimines.
J.Am.Chem.Soc., 123, 2001
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1N4M
 | | Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2 | | Descriptor: | Retinoblastoma Pocket, Transcription factor E2F2 | | Authors: | Lee, C, Chang, J.H, Lee, H.S, Cho, Y. | | Deposit date: | 2002-10-31 | | Release date: | 2003-01-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor
GENES DEV., 16, 2002
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1N6A
 | | Structure of SET7/9 | | Descriptor: | S-ADENOSYLMETHIONINE, SET domain-containing protein 7 | | Authors: | Kwon, T.W, Chang, J.H, Kwak, E, Lee, C.W, Joachimiak, A, Kim, Y.C, Lee, J, Cho, Y. | | Deposit date: | 2002-11-09 | | Release date: | 2003-02-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet
EMBO J., 22, 2003
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